Antenatal excessive sodium intake induces adverse vascular remodelling in offspring

Maternal high‐salt diet altered PKC/MLC20 pathway and increased ANG II receptor‐mediated vasoconstriction in adult male rat offspring

“…Several studies have shown that maternal HSD may affect cardiac structures in adult rat offspring, including vascular remodeling . In the present study, maternal HSD resulted in changes in the ultrastructure of CAs of 5‐month‐old male offspring, such as myofilament derangements and myofilament breakages.…”

“…A number of prenatal insults may initiate programs for certain cardiovascular problems and may increase the offspring's risk of these diseases . Maternal high‐salt diets (HSDs) may influence fetal development and be linked to the cardiovascular pathogenesis . However, the underlying mechanisms remain unclear.…”

Maternal high salt diet altered Adenosine‐mediated vasodilatation via PKA/BK channel pathway in offspring rats

“…Reducing salt by 3 gm/day resulted in fewer coronary diseases, fewer strokes, fewer myocardial infarction, and fewer deaths from any cause annually . Intake of HS in pregnancy showed adverse effects on fetal development and cardiovascular systems in the offspring . Our previous study demonstrated that maternal HS diets affected vasoconstriction of coronary arteries in the rat offspring.…”

Tissue Sodium Accumulation: Pathophysiology and Clinical Implications

“…In support of this notion, a prenatal high-salt diet in Sprague-Dawly rats has been shown to program blood pressure and heart rate hyperresponsiveness in adult female offspring [78]. Moreover, the adverse effects of excessive sodium intake during pregnancy on the vascular structure of adult offspring have been documented by demonstrating a thicker wall of central arteries, collagen deposition, smooth muscle cell proliferation, and an increased expression of the OS marker, nitrothyrosine [79,80]. The oxidative damage of the vascular wall has been claimed to be accounted for by high levels of circulating cardiotonic steroid marinobufagenin (MBG), which is known to mediate the production of superoxide and peroxynitrite via NADPH oxidase activation [81].…”