Antenatal diagnosis, prevalence and outcome of major congenital anomalies in Saudi Arabia : A hospital-based study

Sallout, BahauddinI; Al-Hoshan, ManalS; Attyyaa, RehamA; Suleimat, AbdelmaneA Al

doi:10.4103/0256-4947.51703

Cited by 21 publications

(28 citation statements)

References 5 publications

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“…Similar findings were found in a Saudi Arabian study on antenatal prevalence of congenital anomalies which showed a median gestational age at diagnosis of 31 weeks [10]. In contrast, the Eurofetus study showed a mean gestational age at diagnosis of 24.2 weeks likely due to the differing health care system and health-seeking behavior in Europe [14].…”

Section: Discussionsupporting

confidence: 74%

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Screening for congenital fetal anomalies in low risk pregnancy: the Kenyatta National Hospital experience

Onyambu

Tharamba

2018

BMC Pregnancy Childbirth

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BackgroundCongenital malformations contribute significantly to the disease burden among children globally. A study conducted in Kenya on understanding the burden of surgical congenital anomalies, highlights the need for Kenyan health systems to go beyond the medical dimensions of illness. This could be achieved by linking knowledge of the severe congenital anomalies (CAs) and their impact of varying disability to the delivery of local health services and public health program planning. Subsequently, early detection of these congenital anomalies is vital and can be achieved through fetal ultrasonography.Studies have proven that antenatal ultrasound can successfully diagnose fetal abnormalities in many cases and therefore aid in counseling of parents and planning for early intervention.Although there are studies on screening of congenital anomalies in various populations, very few have been done in the African population and none to the best of our knowledge has been done in Kenya.MethodsThe patients, who underwent routine obstetric ultrasounds, were recruited into the study. The study population comprised patients who were referred from the obstetric clinic, casualty and other clinics within the hospital vicinity. Data of antenatal ultrasounds was statistically analyzed on structured data collection form to determine the prevalence of congenital anomalies.ResultsFifteen fetal anomalies were diagnosed in 500 women who came for routine ultrasound (3%). The mean age of the mothers was 28.2 years (SD ± 4.5) with an age range from 15 to 44 years. 400 (80%) of the mothers were aged between 27 and 34 years.The most frequently observed fetal anomalies involved the head (8/ 500; 1.6%). Each of the remaining anomalies affected less than 1% of the fetuses and included anomalies of the spine (2/ 500; 0.4%), pulmonary (2/ 500; 0.4%), renal and urinary tract (2/ 500; 0.4%) and skeletal systems (2/ 500; 0.4%). Majority, 9 of 15 (60%) of the fetuses with anomalies detected on prenatal ultrasound resulted in postnatal mortality within days of delivery.ConclusionCongenital anomalies prevalence in our setting compares with those found in other studies. From this study, major birth defects are a major cause of perinatal mortality.

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Section: Discussionsupporting

confidence: 74%

“…A further study done in Madina Teaching Hospital, Faisalabad on grayscale ultrasound showed a comparable antenatal prevalence of 2.97% [9]. Another similar Saudi Arabian study produced a figure of 2.79% [10]. …”

Section: Discussionmentioning

confidence: 98%

Screening for congenital fetal anomalies in low risk pregnancy: the Kenyatta National Hospital experience

Onyambu

Tharamba

2018

BMC Pregnancy Childbirth

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“…This rate in a study in Saudi Arabia was 34.9% (11). The mortality rate in our study was greater than the rate reported by studies in Turkey (14% -15.5%) (17,29) and Denmark (1.61%) (43) and less than the rate reported by studies conducted in Birjand (78%) (23) and Libya (49.1%) (18).…”

Section: Discussioncontrasting

confidence: 55%

“…Similarly, a study in Saudi Arabia showed that 66.6% of major CAs were isolated and 33.4% were multiple. The most common CAs in Saudi Arabia were urinary (11,28) and cranial anomalies (11). A study in Turkey also reported that 76% of CAs were isolated and 24% of them were multiple (29).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Major Congenital Anomalies Among Live Births in Birjand, Iran

2018

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Background and Objectives: Congenital anomalies can increase the neonatal mortality rate. Infants with anomalies suffer from long-term disabilities that impose heavy burdens on their families and healthcare systems. Understanding the prevalence of congenital anomalies helps health policy-makers develop better health-related policies. This study aimed to evaluate the prevalence of major congenital anomalies among live births in Birjand city, Iran. Methods: This cross-sectional descriptive-analytical study was conducted on 6,000 infants who were born from September 23, 2015, to March 6, 2016, in the maternity departments in Birjand. Stillbirths and infants who died immediately after birth, i.e. before the assessment for anomalies, were excluded. On the first day of birth, a neonatologist or a pediatrician performed a careful physical examination for each infant to diagnose probable congenital anomalies. Appropriate diagnostic procedures were also used to confirm the diagnosis when needed. Then, data on the characteristics of infants were collected using a researcher-made checklist. The data were reported using descriptive statistics such as absolute frequency, relative frequency, mean, and standard deviation. Moreover, the Chi-square and Fisher's exact tests were conducted using the SPSS computer program (v. 16.0) for hypothesis testing at a significance level of less than 0.05. Results: The prevalence of major congenital anomalies was 1.83 cases per 1000 live births. The prevalence rates of low birth weight and prematurity were significantly greater among infants with congenital anomalies than in their non-afflicted counterparts (45.5% vs. 15.9% and 36.4% vs. 11.1%, respectively; P < 0.05). Around 63.6% of the anomalies were among male infants and 54.5% of parents had kinship relationships. Conclusions: This study showed that the prevalence of major congenital anomalies among live births in Birjand was 1.83 cases per 1000 live births, which is less than the rates reported in other areas of Iran.

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“…Salute et al . [8] showed that genitourinary anomalies were the most common fetal anomalies diagnosed in the antenatal period constituting 38.6% of all anomalies diagnosed in that center. However, the prevalence and pattern of CAKUT was not reported.…”

Section: Discussionmentioning

confidence: 99%

Antenatal diagnosis, prevalence and outcome of congenital anomalies of the kidney and urinary tract in Saudi Arabia

Bondagji

2014

Urol Ann

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Objective:To study the prevalence, pattern of distribution, and the outcome of different types of kidney and urinary tract anomalies (CAKUT) diagnosed during the antenatal period. The second objective is to test the accuracy of antenatal diagnosis of CAKUT.Materials and Methods:In a cross-sectional hospital-based study, all cases diagnosed antenatally with urinary tract anomalies at King Abdulaziz University Hospital (KAUH), Jeddah, Kingdom of Saudi Arabia, were studied. The prevalence, pattern of distribution, and immediate postnatal outcomes, in addition to the accuracy of antenatal diagnosis, of those cases are reported.Results:One hundred and forty-one cases of urinary tract anomalies were antenatally diagnosed; postnatal diagnosis was confirmed in 128 cases (90.1%). The prevalence of CAKUT in our population is 3.26 per 1000 births. The most common abnormalities detected were hydronephrosis, polycystic kidney disease, multicystic dysplastic kidney, and renal agenesis, in descending order of frequency. The perinatal mortality rate among fetuses with CAKUT is 310 per 1000, the majority of these cases (90%) occurred in cases with renal parenchyma involvement.Conclusions:The prevalence of different types of CAKUT is higher than that reported in developed countries. Urinary tract anomalies can be accurately diagnosed and classified in the antenatal period using ultrasonography imaging. Antenatal diagnosis is a helpful tool in planning immediate postnatal care and deciding the place for delivery. This might prevent or slow renal function deterioration and help in early identification of patients who need early surgical intervention.

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Antenatal diagnosis, prevalence and outcome of major congenital anomalies in Saudi Arabia : A hospital-based study

Cited by 21 publications

References 5 publications

Screening for congenital fetal anomalies in low risk pregnancy: the Kenyatta National Hospital experience

Screening for congenital fetal anomalies in low risk pregnancy: the Kenyatta National Hospital experience

The Prevalence of Major Congenital Anomalies Among Live Births in Birjand, Iran

Antenatal diagnosis, prevalence and outcome of congenital anomalies of the kidney and urinary tract in Saudi Arabia

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