“…Also, many genetic disorders, among them a number of serious hereditary skin diseases, are not amenable to diagnosis by these methods. Several of these genodermatoses (in particular epidermolyses and keratinization disorders) can be identified only by ultrastructural diagnostic criteria, and second trimester fetoscopy combined with fetal skin sampling is successfully utilized for their prenatal diagnosis (Anton-Lamprecht, 1978;Elias et al, 1980;Golbus et al, 1980;Rodeck et al, 1980;Anton-Lamprecht, 1981, 1988Esterly and Elias, 1983;Anton-Lamprecht and Arnold, 1987a, b;Arnold and Anton-Lamprecht, 1987). Skin and chorionic villi share, at least during the first trimester, a number of attributes.…”