Antenatal dexamethasone and renal vascular resistance in preterm infants

Amador-Licona, Norma; Guízar-Mendoza, Juan Manuel; Maciel-Miranda, Jesús Alejandro; Romero-Gutiérrez, Gustavo

doi:10.1111/j.1440-1754.2007.01063.x

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…In a previous study, we detected that preterm newborn with antecedent steroid therapy displayed hemodynamic changes and a greater renal artery resistance [17]. However, we were unable to determine whether these changes are transitory or whether they represent some repercussion in renal function in later ages.…”

Section: Introductionmentioning

confidence: 75%

Renal function, renal volume, and blood pressure in infants with antecedent of antenatal steroids

et al. 2011

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Steroids have been used for more than 20 years in preterm infants to induce pulmonary maturity; however, some long-term effects have been reported, such as insulin resistance and elevation of blood pressure. The aim of our study was to compare renal volume, renal function, and blood pressure in infants between 12-36 months of age with and without antecedent of antenatal steroid treatment. This was a cross-sectional study comprised of three groups of infants (n = 30, respectively): preterm infants with and without antecedent of receiving antenatal steroids, respectively, and full-term infants. Blood pressure, renal volume, glomerular filtration rate, and tubular function were measured. Blood pressure and cystatin C levels and glomerular filtration rate were higher in both groups of preterm infants than in the control group (p < 0.01). However, no difference in any of the tested variables between the steroid and non-steroid group of preterm infants. Renal volume was similar in preterm and control infants. Based on these results, we conclude that prematurity independent of antenatal steroid use is associated with higher cystatin C and blood pressure levels and a higher glomerular filtration rate in infants between 12-36 months of age.

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Section: Introductionmentioning

confidence: 75%