Antenatal detection of IgM and IgG antibodies to<i>Toxoplasma gondii</i>in a hospital from central India

Patel, Kamlesh Kumar; Shrivastava, Gunjan; Bhatambare, Ganesh S; Bajpai, Trupti

doi:10.4103/2347-9019.142188

Cited by 6 publications

(6 citation statements)

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“…Rubella courses with mild degree of rashes and fever in childhood, when it is experienced in the first months of pregnancy, it can lead to pregnancy losses and stillbirths and during the neonatal period it may result in “Congenital Rubella Syndrome” (CRS) [1, 2, 3]. For the possible prevention of vertical transmittance from mother to the fetus, seronegative women should be detected during preconceptional period, and their pregnancies should be planned, and postponed after immunization.…”

Section: Discussionmentioning

confidence: 99%

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TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals

Numan

Vural

Aka

et al. 2016

North Clin Istanbul

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OBJECTIVE:Toxoplasma gondii, Rubella, Cytomegalovirus and Herpes simplex viruses are microorganisms that cause congenital infections and they are called briefly as TORCH. There is an ongoing argument for the screening of reproductive age women due to the high cost of tests. For a test to be used in screening, prevalence of disease in this population should be known. The aim of this study was to investigate TORCH seroprevalence among women attending a teaching hospital in Istanbul.METHODS:A total of 1101 patients attending outpatient clinic of Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals between September 2013 to January 2015 and their laboratory data were evaluated retrospectively. We investigated Ig G and M seropositivity rates against TORCH.RESULTS:The age of the patients ranged between 17–47 years with a mean age of 30.3±5.8 years. Pregnant population had 99.5% anti-CMV Ig G (+), 94.2% anti-Rubella Ig G (+), 31% anti-Toxoplasma Ig G (+). Seroprevalence for Anti IgM was 0.5% for CMV, 0.2% for rubella.CONCLUSION:The screening for Toxoplasma gondii may be suggested since the prevalence is not high in our population. The screening of CMV is not meaningful, due to high seroprevalence. Although seroprevalence of rubella is also high, it may be suggested for preconception vaccination especially in women above 20 years of age born prior to National Vaccination Programme.

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Section: Discussionmentioning

confidence: 99%

“…The spectrum of congenital infection extends from asymptomatic findings up to intrauterine fetal loss and may include chorioretinitis, hearing sequelae, hydrocephalus, mental and psychomotor disorders [3]. As gestational weeks progress, risk of vertical transfer increases and the risk of infection leading to more serious malformations decreases [4].…”

mentioning

confidence: 99%

TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals

Numan

Vural

Aka

et al. 2016

North Clin Istanbul

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“…Symptoms such as headache, fever, fatigue, and muscle pain are rare (4). Although T. gondii causes ventriculomegaly, intracranial and intrahepatic calcifications, hepatomegaly, acid, pleural effusion in the fetus, and increased thickness in the placenta during the intrauterine period, it may also cause hydrocephaly, motor intellectual disability, seizure, hearing and vision loss, hepatosplenomegaly, anemia, thrombocytopenia, and even death in newborns (5).…”

Section: Introductionmentioning

confidence: 99%

Is routine TORCH screening necessary for pregnancy follow-up?

Kale

Bayık

Uluutku³

et al. 2020

Türk Kadın Sağlığı Ve Neonatoloji Dergisi

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Aim: This study aimed to determine the seroprevalence rates of Toxoplasma gondii, Rubella and Cytomegalovirus (CMV) among the pregnant women who presented to the Ümraniye Training and Research Hospital and to compare the seroprevalence rates with the other studies fromTurkey. Material and method:The antibody levels of all pregnant women presented to the prenatal outpatient clinic between January 1, 2017 and October 30, 2019, for Toxoplasma gondii, Rubella, CMV were obtained retrospectively. Only pregnant women with immunoglobulin M (IgM) and immunoglobulin G (IgG) antibody results of the three viruses were included in the study. If IgM and IgG were both found to be positive, the IgG avidity results were obtained using the Abbott Architect i2000 SR device with enzyme-linked immunosorbent assay (ELISA), following the manufacturer's recommendations.Results: Serological results of pregnant women for Toxoplasma gondii (n = 7535), Rubella (n = 9093), and CMV (n = 2652) were obtained from the hospital records. IgM positivity was found to be 0.6% for Toxoplasma gondii, 0.3% for Rubella, and 2.3% for CMV. IgG positivity was found to be 24% for Toxoplasma gondii, 86.4% for Rubella, and 99% for CMV. IgG avidity test results for Toxoplasma gondii were 5.3% low, 10.5% borderline, and 84.2% high. Rubella IgG and CMV IgG avidity results were all determined following high avidity. Conclusion:Because Toxoplasma IgG seroprevalence is not high, and the treatment of acute toxoplasmosis infection during pregnancy is possible, Toxoplasma screening should be recommended to all pregnant women. Because the immunity to the Rubella virus is still not at the desired level in our country, we believe screening against Rubella is vital during pregnancy. We also believe that routine CMV screening is unnecessary in pregnant women owing to the high seroprevalence of CMV IgG in our country.

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“…TORCH pathogens have medical importance for women with bad obstetric history because all of these microorganisms are capable of crossing placental barriers and causing fetal infections and abnormalities (Patel et al 2014). Maternal infections in pregnancy occur during any time of gestation and the severity of the infection depends on many factors such as the virulence of the agents, immune status of the mother, gestational age of the fetus, the route of infection, and the dose of the agent (Mcleod & Remington 2000).…”

Section: Introductionmentioning

confidence: 99%

Serodiagnosis of Torch Infections among Aborted Women in Duhok City/ Kurdistan Region /iraq

Murad

Eassa

Al-Saeed

2019

juod

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TORCH syndrome is a cluster of symptoms caused by congenital infection with (Toxoplasma gondii, Rubella virus, Cytomegalovirus, Herpes simplex virus, and other pathogens such as Hepatitis B virus antigen and syphilis) during the gestation period of pregnancy. The infection might lead to fetal abnormalities or abortion. Objective: The current study was done to detect TORCH pathogens, hepatitis B virus, and syphilis antigens in women with a previous history of recurrent abortion using serological test in Duhok city. Materials and method: A direct rapid test was used as a serological method for the detection of IgM and IgG antibodies against TORCH pathogens as well as the seropositivity of HBV antigen and syphilis. A total of 90 pregnant women with bad obstetric history were included in the current study throughout April-August 2017 in Duhok City/ Kurdistan Region/Iraq. Results: The total seropositivity of anti-pathogens (Toxoplasma gondii, Rubella virus, Cytomegalovirus, and Herpes virus) were 19/90(21.1%), 17/90(18.9), 16/90(17.8), 16/90(17.8%) and for HBs Ag and syphilis 3/90 (3.3%) and syphilis 1/90(1.1%) respectively. The IgM and IgG seropositivity to Toxoplasma gondii, Rubella virus, Cytomegalovirus, and Herpes viruses were (13.3% and 7.8%), (10.0% and 8.9%), (10.0% and 7.8%), and (10.0% and 7.8%) respectively. Seroprevalence of antipathogens IgG and IgM antibodies associated with socioeconomic and demographic characteristics were indicated in the results section. Conclusion: A previous history of pregnancy wastage and the serological test for TORCH infection in addition to HBs Ag and syphilis during current pregnancy must be considered while managing BOH cases as to reduce the adverse fetal outcomes, the early diagnosis of TORCH using serological methods is highly significant.

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Antenatal detection of IgM and IgG antibodies toToxoplasma gondiiin a hospital from central India

Cited by 6 publications

References 1 publication

TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals

TORCH seroprevalence among patients attending Obstetric Care Clinic of Haydarpasa Training and Research Hospital affiliated to Association of Istanbul Northern Anatolia Public Hospitals

Is routine TORCH screening necessary for pregnancy follow-up?

Serodiagnosis of Torch Infections among Aborted Women in Duhok City/ Kurdistan Region /iraq

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