Antecedent febrile illness and occurrence of stroke in West Africa: The SIREN study

Ovbiagele, Bruce; Matthew, Onoja Akpa; Akpalu, Albert; Wahab, Kolawole; Obiako, Reginald; Owolabi, Lukman; Asowata, Osahon Jeffery; Ogbole, Godwin; Komolafe, Morenikeji; Akinyemi, Rufus; Owolabi, Mayowa

doi:10.1016/j.jns.2020.117158

Cited by 3 publications

(3 citation statements)

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“…A measure of inflammatory burden is now known as an emerging risk factor for incident stroke and may well predict outcomes. In the SIREN study, we found that 1 in 10 stroke cases reported antecedent history of febrile illness prior to occurrence of stroke suggesting that infectious exposures may be an important trigger of acute cerebral vascular event ( 42 ). Indeed, in previous candidate gene studies of the SIREN cohort, we demonstrated an association between the interleukin – 6 gene locus (rs1800796) and ischaemic stroke ( 43 ).…”

Section: Stroke and Neuroinflammationmentioning

confidence: 99%

Non-Communicable Neurological Disorders and Neuroinflammation

et al. 2022

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Traumatic brain injury, stroke, and neurodegenerative diseases represent a major cause of morbidity and mortality in Africa, as in the rest of the world. Traumatic brain and spinal cord injuries specifically represent a leading cause of disability in the younger population. Stroke and neurodegenerative disorders predominantly target the elderly and are a major concern in Africa, since their rate of increase among the ageing is the fastest in the world. Neuroimmunology is usually not associated with non-communicable neurological disorders, as the role of neuroinflammation is not often considered when evaluating their cause and pathogenesis. However, substantial evidence indicates that neuroinflammation is extremely relevant in determining the consequences of non-communicable neurological disorders, both for its protective abilities as well as for its destructive capacity. We review here current knowledge on the contribution of neuroinflammation and neuroimmunology to the pathogenesis of traumatic injuries, stroke and neurodegenerative diseases, with a particular focus on problems that are already a major issue in Africa, like traumatic brain injury, and on emerging disorders such as dementias.

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Section: Stroke and Neuroinflammationmentioning

confidence: 99%

Non-Communicable Neurological Disorders and Neuroinflammation

et al. 2022

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“…It is often accompanied by ventricular enlargement, a corresponding decrease in brain parenchymal, and increased intracranial pressure [9]. The incidence rate of hydrocephalus in the population is unclear, while the prevalence rate is 1.0%-1.5% [5,21,25]. Hydrocephalus is mostly sporadic without gender differences, and infants (congenital hydrocephalus mostly) and seniors over 60 (idiopathic normal pressure hydrocephalus mostly) are shown as two prone age groups [26,28].…”

Section: Introductionmentioning

confidence: 99%

Surgical Treatment for Pediatric Hydrocephalus: a Report of 163 Clinical Cases in a Single Center

Yang

Zhang

Ding

et al. 2022

Preprint

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Objectives: Surgical treatment is the preferred treatment for pediatric hydrocephalus. The analysis of the outcome of pediatric hydrocephalus surgery and its complications is limited by the lack of available data. Our goal was to better understand the effectiveness of surgery and to explore better surgical treatment methods and management of complications.Methods: 163 patients with pediatric hydrocephalus were included. A retrospective chart review was performed on all patients. Data collected included surgical techniques, number of surgical treatments, complications, and basic demographics.Results: There were 163 patients in this group including 103 males and 60 females. Among the patients, 106 (106/163, 65.0%) patients received ventricular peritoneal shunt (VP), 7 (7/163, 4.3%) patients received ventricle-right atrium shunt (VA) and 50 (50/163, 30.7%) patients received endoscopic third ventriculostomy (ETV). Among the patients who received VP, 74 (74/163, 45.4%) patients were cured and 32 (32/163, 19.6%) patients underwent surgery again. Among the patients who received VA, 38 (38/163, 23.3%) patients were cured and 12 (12/163, 7.4%) patients underwent surgery again. Among the patients who received ETV, 3 (3/163, 1.8%) patients were cured and 4 (4/163, 2.5%) patients underwent surgery again. The most common complication is shunt-related peritonitis or abdominal abscess, abdominal end obstruction (17/163，10.4%).Conclusion: A single surgery can cure most patients, and sometimes more than one surgery is required. For pediatric hydrocephalus, ETV is more efficient and has fewer surgical complications. However, the management of unrelieved symptoms and related complications after ETV surgery and bypass surgery should still be taken seriously.

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“…Subarachnoid hemorrhage (SAH) is a severe form of cerebrovascular disease, with a mortality rate of 40-60% and an incidence of 8-20/10,000 [1][2][3]. It is mainly consecutive to aneurysm rupture.…”

Section: Introductionmentioning

confidence: 99%

Hydrocephalus after aneurysmal subarachnoid hemorrhage: Epidemiology, Pathogenesis, Diagnosis, and Management

2021

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Hydrocephalus is one of the most common complications of aneurysmal subarachnoid hemorrhage (aSAH), which seriously affects the quality of life and shortens the survival time of affected patients. By reviewing the recent studies on the risk factors of aSAH-associated hydrocephalus, we aimed to explicitly present the pathogenesis of acute and chronic hydrocephalus after aSAH and make a comprehensive list of the associated risk factors of aSAH-associated hydrocephalus and shunt-dependent hydrocephalus. It would help us to better explain the occurrence of hydrocephalus after aSAH, especially hydrocephalus caused by inflammation after bleeding. Many studies have recently suggested that high mobility group box 1 may be an early upstream promoter of inflammatory response after aSAH, which also provides important ideas for us to look for potential drug treatments. The surgery, such as external ventricular drain and lumbar drainage, is the most common and effective treatment. Yet, there are often complications, such as rebleeding and intracranial infection, and the optimal timing of intervention is controversial. Besides, this is also a systematic review of the recent advances in epidemiology, pathogenesis, diagnosis, and management of aSAH-associated hydrocephalus.

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Antecedent febrile illness and occurrence of stroke in West Africa: The SIREN study

Cited by 3 publications

References 49 publications

Non-Communicable Neurological Disorders and Neuroinflammation

Non-Communicable Neurological Disorders and Neuroinflammation

Surgical Treatment for Pediatric Hydrocephalus: a Report of 163 Clinical Cases in a Single Center

Hydrocephalus after aneurysmal subarachnoid hemorrhage: Epidemiology, Pathogenesis, Diagnosis, and Management

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