Antarctic red macroalgae: a source of polyunsaturated fatty acids

Santos, Marco Aurélio Ziemann dos; Colepicolo, Pio; Pupo, Diclá; Fujii, Mutuê T.; Pereira, Cláudio M. P.; Mesko, Márcia F.

doi:10.1007/s10811-016-1034-x

Cited by 33 publications

(18 citation statements)

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“…Chemical evaluation -Previous reports in the literature indicated that lipophilic extracts from red, green and brown macroalgae from the coast of Portugal had 0.12 ± 0.01% DW to 2.94 ± 0.08% DW which agree with the results found in the current research work (Santos et al 2015(Santos et al , 2016. Since methods used in both studies were similar, possible differences in the extractive yield can be associated with the macroalgae species, extractor solvent and the distinct locations that the organisms were retrieved from (Santos et al 2017a). The presence of several classes that can include fatty acids, hydrocarbons, sterols and fatty alcohols has been reported in the analysis of lipophilic extracts from marine macroalgae (Valentão et al 2010).…”

Section: Discussionsupporting

confidence: 90%

“…Santos et al (2017b) and Cortés et al (2014) analyzed dichloromethane extracts from Bifurcaria bifurcata R.Ross and Ceramium rubrum C. Agardh, respectively, and detected similar compounds (Cortés et al 2014;Santos et al 2017b). It is worth noting that, to the best of our knowledge, this was the first time that lipophilic extracts from M. laminarioides at distinct phases The presence and concentration of secondary metabolites in macroalgae are controlled by several environmental conditions that include, for instance, temperature, seasonality, pH, salinity and development phase (Santos et al 2017a;Berneira et al 2020). In this sense, evaluation of the life stages of M. laminarioides revealed significant differences (P < 0.05) in the chemical classes as the cystocarpic phase had higher concentrations of hydrocarbons and fatty acids than other development phases.…”

Section: Discussionmentioning

confidence: 78%

“…Identification of bioactive compound sources and screening for potential pharmacological activities are important aspects in order to develop novel tools for disease treatment (Santos et al 2015;Martins et al 2018). In this sense, macroalgae are reservoirs for possible bioactive compounds given their ability to biosynthesize secondary metabolites against environmental stress that include limited photoperiod, low temperatures and decreased nutrient availability (Santos et al 2017a;Passos et al 2020). Moreover, these organisms can be found in several locations of the planet including tropical, sub-Antarctic and Antarctic regions highlighting their biological potential (Santos et al 2016;Schmid et al 2018).…”

Section: Introductionmentioning

confidence: 99%

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Bioactivity evaluation and composition of extracts from sub-Antarctic macroalgae Mazzaella laminarioides at distinct development phases

et al. 2020

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Sub-Antarctic macroalgae can be a feasible source of innumerous bioactive compounds that can display important biological activities. In this sense, the aims of this work were to evaluate the chemical composition, antimicrobial activity and cytotoxic potential of n-hexane extracts from sub-Antarctic seaweed Mazzaella laminarioides (Bory) Fredericq at distinct development phases. Results showed that extracts were constituted of as much as 65 distinct compounds that could be distributed mainly among hydrocarbons, fatty acids, sterols and fatty alcohols. Generally, there were significant differences (P < 0.05) in the concentrations of compounds comparing distinct development phases. Antimicrobial evaluation indicated that n-hexane extracts of cystocarpic and tetrasporophytic phase of M. laminarioides inhibited the growth of most organisms tested, reaching minimum inhibitory concentrations of 0.0312 mg mL −1 against Enterococcus faecalis (Andrewes and Horder) and 0.25 mg mL −1 against Acinetobacter baumannii (Bouvet and Grimont). Cytotoxic evaluation of extracts showed no toxicity to normal cells at concentrations below 1 mg mL −1. Therefore, M. laminarioides from the sub-Antarctic region had antimicrobial potential that could be explored on further commercial applications.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 99%

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Bioactivity evaluation and composition of extracts from sub-Antarctic macroalgae Mazzaella laminarioides at distinct development phases

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“…Although considerable progress has been made in recent years, our knowledge on the region's macroalgae is still fragmented. Recent studies on these algae have revealed a fatty acid profile (Santos et al, 2017 ) and steroids (Pereira et al, 2017 ). Moreover, other studies have been carried out in the Chilean sub-Antarctic region where these algae are abundant and may be exploited for bioprospecting research (Wiencke et al, 2007 ; Astorga-España and Mansilla, 2014 ; Fujii et al, 2014 ; Kim et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Macroalgae Extracts From Antarctica Have Antimicrobial and Anticancer Potential

et al. 2018

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Background: Macroalgae are sources of bioactive compounds due to the large number of secondary metabolites they synthesize. The Antarctica region is characterized by extreme weather conditions and abundant aggregations of macroalgae. However, current knowledge on their biodiversity and their potential for bio-prospecting is still fledging. This study evaluates the antimicrobial and cytotoxic activity of different extracts of four macroalgae (Cystosphaera jacquinotii, Iridaea cordata, Himantothallus grandifolius, and Pyropia endiviifolia) from the Antarctic region against cancer and non-cancer cell lines.Methods: The antimicrobial activity of macroalgae was evaluated by the broth microdilution method. Extracts were assessed against Staphylococcus aureus ATCC 19095, Enterococcus faecalis ATCC 4083, Escherichia coli ATCC29214, Pseudomonas aeruginosa ATCC 9027, Candida albicans ATCC 62342, and the clinical isolates from the human oral cavity, namely, C. albicans (3), C. parapsilosis, C. glabrata, C. lipolytica, and C. famata. Cytotoxicity against human epidermoid carcinoma (A-431) and mouse embryonic fibroblast (NIH/3T3) cell lines was evaluated with MTT colorimetric assay.Results: An ethyl acetate extract of H. grandifolius showed noticeable antifungal activity against all fungal strains tested, including fluconazole-resistant samples. Cytotoxicity investigation with a cancer cell line revealed that the ethyl acetate extract of I. cordata was highly cytotoxic against A-431 cancer cell line, increasing the inhibitory ratio to 91.1 and 95.6% after 24 and 48 h exposure, respectively, for a concentration of 500 μg mL−1. Most of the algal extracts tested showed little or no cytotoxicity against fibroblasts.Conclusion: Data suggest that macroalgae extracts from Antarctica may represent a source of therapeutic agents.HIGHLIGHTS Different macroalgae samples from Antarctica were collected and the lyophilized biomass of each macroalgae was extracted sequentially with different solventsThe antimicrobial and anticancer potential of macroalgae extracts were evaluatedEthyl acetate extract of H. grandifolius showed noticeable antifungal activity against all the fungal strains tested, including fluconazole-resistant samplesEthyl acetate extract of I. cordata was highly cytotoxic against the A-431 cancer cell lineMost of the algal extracts tested showed little or no cytotoxicity against normal cell lines

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“…Adicionalmente, Santos et al (2017) analisando P. endiviifolia Choi & Hwang em condições de congelamento, evidenciaram o incremento de ácidos graxos poli-insaturados. Assim, os estudos demonstraram que a diminuição das temperaturas geralmente leva ao aumento do grau de insaturação nos ácidos graxos para contribuir com a estabilidade e fluidez das membranas (Lynch & Thompson, 1984).…”

Section: Discussionunclassified

Efeito do estresse térmico sobre respostas fisiológicas, composição química e potencial antioxidante de Sargassum stenophyllum (Fucales, Ochrophyta) e Pyropia spiralis (Bangiales, Rhodophyta)

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Antarctic red macroalgae: a source of polyunsaturated fatty acids

Cited by 33 publications

References 61 publications

Bioactivity evaluation and composition of extracts from sub-Antarctic macroalgae Mazzaella laminarioides at distinct development phases

Bioactivity evaluation and composition of extracts from sub-Antarctic macroalgae Mazzaella laminarioides at distinct development phases

Macroalgae Extracts From Antarctica Have Antimicrobial and Anticancer Potential

Efeito do estresse térmico sobre respostas fisiológicas, composição química e potencial antioxidante de Sargassum stenophyllum (Fucales, Ochrophyta) e Pyropia spiralis (Bangiales, Rhodophyta)

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