Antagonizing correlation between periodic synchronous discharges and photically induced giant evoked responses in Creutzfeldt‐Jakob disease (Heidenhain type): A case study

Jibiki, Itsuki; Fukushima, Toshinobu; Kobayashi, Kanako; Aoki, Tatsuto; Yamaguchi, Nariyoshi

doi:10.1111/j.1440-1819.1995.tb01864.x

Cited by 6 publications

(2 citation statements)

References 3 publications

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“…This case previously reported by Jibiki et al ., 13 clinically diagnosed as having Heidenhain syndrome, had unusual EEG features in which photically evoked responses suppressed PSD. The necropsy disclosed a spongiform change, neuronal loss and astrocytosis in the LGB and pregeniculate nucleus as well as in other gray and white matter.…”

Section: Introductionmentioning

confidence: 57%

An autopsied case of Creutzfeldt‐Jakob disease with the lateral geniculate body lesion showing antagonizing correlation between periodic synchronous discharges and photically induced giant evoked responses

Aoki

Kobayashi

Jibiki

et al. 1998

Psychiatry Clin Neurosci

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We reported an necropsy finding of a patient with Creutzfeldt-Jakob disease (CJD) who showed photo-stimulated giant spikes that simultaneously suppressed periodic synchronous discharges (PSD) and the loss of pupillary light reflex during the course of the illness. The necropsy revealed extensive gray and white matter lesions, and both the lateral geniculate body (LGB) and pregeniculate body were primarily affected. The superior colliculus, optic nerve and tracts were not affected. The cerebral cortices particularly of the occipital lobe were severely damaged. The Gennari line, however, was spared from lesion. The primary involvement of the LGB has been reported infrequently in CJD, however, it appears to be associated with the unusual electroencephalograph (EEG) feature of the present case. The pregeniculate lesion contributed to the loss of pupillary reflex. This finding indicates that the visual pathway may be involved in the mechanism of the generation of PSD in CJD.

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Section: Introductionmentioning

confidence: 57%

An autopsied case of Creutzfeldt‐Jakob disease with the lateral geniculate body lesion showing antagonizing correlation between periodic synchronous discharges and photically induced giant evoked responses

Aoki

Kobayashi

Jibiki

et al. 1998

Psychiatry Clin Neurosci

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show abstract

“…5,10,12,14,24,[26][27][28][29][30]34,55,97,107,108,118,[123][124][125][126] Early studies found that the overall incidence of cortical blindness in CJD was about 13%/-8 but more recent studies suggest that it develops at some stage in the illness in 25-50% of cases? , 1 27, 1 28 Possible reasons for this discrepancy are that patients may deny they are blind (Anton's syndrome)p ,34,60,65, 1 26 or may be too inconsistent to permit accurate assessment of visual fields.68 About 9% of patients are blind at presentation.1 28…”

Section: Cortical Blindnessmentioning

confidence: 99%