Antagonistic toxicity of carbon nanotubes and pentachlorophenol to Escherichia coli: Physiological and transcriptional responses

Deng, Rui; Zhu, Ya; Hou, Jie; White, Jason C.; Gardea‐Torresdey, Jorge L.; Lin, Daohui

doi:10.1016/j.carbon.2019.01.077

Cited by 24 publications

(7 citation statements)

References 64 publications

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“…In a previous study, combined toxicity of functionalized MWCNTs and B[a]P showed a slight antagonistic toxic interaction (Mohammadian et al, 2018). Antagonistic toxicity interaction of CNTs and organic component also have been reported in previous studies (Deng et al, 2019; Rezazadeh et al, 2019; Yi et al, 2019). The CNTs adsorb PAHs, and the decrease of PAH bioavailability was a mechanism of antagonistic toxicity interaction (Glomstad et al, 2016; Shrestha et al, 2015).…”

Section: Discussionsupporting

confidence: 84%

Antagonistic effect of co-exposure to short-multiwalled carbon nanotubes and benzo[a]pyrene in human lung cells (A549)

et al. 2019

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In theenvironment, co-exposure to short-multiwalled carbon nanotubes (S-MWCNTs) and polycyclic aromatic compounds (PAHs) has been reported. In the co-exposure condition, the adsorption of PAHs onto MWCNTs may reduce PAHs toxic effect. The objective of this study was to investigate the cytotoxicity of S-MWCNTs and benzo[a]pyrene (B[a]P) individually, and in combination in human lung cell lines (A549). The adsorption of B[a]P onto MWCNTs was measured spectrometrically. In vitro toxicity was assessed through cell viability, reactive oxygen species (ROS) generation, apoptosis, and 8-hydroxy-2′-deoxyguanosine (8-OHdG) generation experiments. The S-MWCNTs demonstrated cytotoxicity through the generation of ROS, apoptosis, and 8-OHdG in A549 cells. Co-exposure to S-MWCNTs and B[a]P demonstrated a significant reduction in ROS generation and apoptosis compared with the sum of their separate toxic effects at the same concentrations. Decreasing the bioavailability of B[a]P by MWCNT interaction is the probable reason for the antagonistic effects of the co-exposure condition. The findings of this study will contribute to a better understanding of the health effects of co-exposures to air pollutants and could be a starting point for modifying future health risk assessments.

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Section: Discussionsupporting

confidence: 84%

Antagonistic effect of co-exposure to short-multiwalled carbon nanotubes and benzo[a]pyrene in human lung cells (A549)

et al. 2019

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“…This study thus demonstrated that transcriptomics can serve as a sensitive tool in revealing ENM effects that could be useful in fighting antibiotic resistance. On the other hand, there are reports on antagonistic activity of oxidized MWCNTs and organic compounds such as the pesticide pentachlorophenol ( Deng et al, 2019 ) and the antibiotic ciprofloxacin ( Deng et al, 2020 ). Transcriptomics and a combination of transcriptomics and metabolomics, respectively, indicated that MWCNTs attenuated the pentachlorophenol-induced disturbances in gene expression ( Deng et al, 2019 ) and offset the impact of ciprofloxacin in E. coli gene expression and its metabolome ( Deng et al, 2020 ).…”

Section: Resultsmentioning

confidence: 99%

“…On the other hand, there are reports on antagonistic activity of oxidized MWCNTs and organic compounds such as the pesticide pentachlorophenol ( Deng et al, 2019 ) and the antibiotic ciprofloxacin ( Deng et al, 2020 ). Transcriptomics and a combination of transcriptomics and metabolomics, respectively, indicated that MWCNTs attenuated the pentachlorophenol-induced disturbances in gene expression ( Deng et al, 2019 ) and offset the impact of ciprofloxacin in E. coli gene expression and its metabolome ( Deng et al, 2020 ). The different outcomes of MWCNT exposures to the toxicity of organic compounds in bacteria may be caused by the physico-chemical properties of these compounds that influence their interactions with MWCNTs and bacteria, or depend on whether pre- or co-exposures of MWCNTs with the antibiotics were conducted.…”

Section: Resultsmentioning

confidence: 99%

Molecular Mechanisms of Nanomaterial-Bacterial Interactions Revealed by Omics—The Role of Nanomaterial Effect Level

Mortimer

Wang

Holden

2021

Front. Bioeng. Biotechnol.

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Nanotechnology is employed across a wide range of antibacterial applications in clinical settings, food, pharmaceutical and textile industries, water treatment and consumer goods. Depending on type and concentration, engineered nanomaterials (ENMs) can also benefit bacteria in myriad contexts including within the human body, in biotechnology, environmental bioremediation, wastewater treatment, and agriculture. However, to realize the full potential of nanotechnology across broad applications, it is necessary to understand conditions and mechanisms of detrimental or beneficial effects of ENMs to bacteria. To study ENM effects, bacterial population growth or viability are commonly assessed. However, such endpoints alone may be insufficiently sensitive to fully probe ENM effects on bacterial physiology. To reveal more thoroughly how bacteria respond to ENMs, molecular-level omics methods such as transcriptomics, proteomics, and metabolomics are required. Because omics methods are increasingly utilized, a body of literature exists from which to synthesize state-of-the-art knowledge. Here we review relevant literature regarding ENM impacts on bacterial cellular pathways obtained by transcriptomic, proteomic, and metabolomic analyses across three growth and viability effect levels: inhibitory, sub-inhibitory or stimulatory. As indicated by our analysis, a wider range of pathways are affected in bacteria at sub-inhibitory vs. inhibitory ENM effect levels, underscoring the importance of ENM exposure concentration in elucidating ENM mechanisms of action and interpreting omics results. In addition, challenges and future research directions of applying omics approaches in studying bacterial-ENM interactions are discussed.

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“…During the use and treatment process, CNTs could enter into the sewage treatment plant as pollutant or adsorbent, which will pose potential risk to microbial treatment unit or natural waters. Due to the interaction of CNTs with coexisting pollutants such as organic pollutants and heavy metals, the combined toxicity of CNTs and cocontaminants to microorganisms has been paid more and more attention (Schwab et al, 2013;Glomstad et al, 2016;Deng et al, 2019Deng et al, , 2020).…”

Section: Introductionmentioning

confidence: 99%

Effects of sodium dodecyl benzene sulfonate on the combined toxicity of multi-walled carbon nanotubes and cadmium to Escherichia coli

Yong

Pei

et al. 2022

Preprint

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The combined biological toxicity of carbon nanotubes (CNTs) and the coexisting pollutants have attracted increasing attention. As a common used surfactant, sodium dodecyl benzenesulfonate (SDBS) could interact with both CNTs and heavy metals. Escherichia coli ( E.coli ) was chosen as a model microorganism, and the effects of SDBS on the combined toxicity of three types of multi-walled carbon nanotubes (MWCNTs) and Cd 2+ were studied. The three types of MWCNTs with the concentration below 200 mg∙L -1 didn’t show obvious growth inhibition to E.coli , and they reduced the toxicity of Cd 2+ to different degrees with the order of carboxylated MWCNTs > hydroxylated MWCNTs > MWCNTs without surface functional groups. The combined toxicity of all the three types of MWCNTs and 10 mg∙L -1 of Cd 2+ increased with the increasing SDBS concentration. The free Cd 2+ and Cd 2+ complexing with SDBS (SDBS-Cd + ) were the main toxicity sources for the mixture of MWCNTs, Cd 2+ , and SDBS. SDBS-Cd + increased the bacterial outer membrane permeability, and thus enhanced the combined toxicity of Cd 2+ and MWCNTs. The results could provide a scientific basis for the ecological risk assessment of water polluted by surfactants, carbon nanotubes and heavy metals.

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Antagonistic toxicity of carbon nanotubes and pentachlorophenol to Escherichia coli: Physiological and transcriptional responses

Cited by 24 publications

References 64 publications

Antagonistic effect of co-exposure to short-multiwalled carbon nanotubes and benzo[a]pyrene in human lung cells (A549)

Antagonistic effect of co-exposure to short-multiwalled carbon nanotubes and benzo[a]pyrene in human lung cells (A549)

Molecular Mechanisms of Nanomaterial-Bacterial Interactions Revealed by Omics—The Role of Nanomaterial Effect Level

Effects of sodium dodecyl benzene sulfonate on the combined toxicity of multi-walled carbon nanotubes and cadmium to Escherichia coli

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