Antagonistic actions of PAK1 and NF2/Merlin drive myelin membrane expansion in oligodendrocytes
Lucas Baudouin,
Noémie Adès,
Kadia Kanté
et al.
Abstract:In the central nervous system, the formation of myelin by oligodendrocytes (OLs) relies on the switch from the polymerization of the actin cytoskeleton to its depolymerization. The molecular mechanisms that trigger this switch have yet to be elucidated. Here, we identified P21‐activated kinase 1 (PAK1) as a major regulator of actin depolymerization in OLs. Our results demonstrate that PAK1 accumulates in OLs in a kinase‐inhibited form, triggering actin disassembly and, consequently, myelin membrane expansion. … Show more
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