Antagonism of the orexin receptors in the ventral tegmental area diminished the stress-induced analgesia in persistent inflammatory pain

Shakerinava, Pedram; Sayarnezhad, Ali; Karimi‐Haghighi, Saeideh; Mesgar, Somaye; Haghparast, Abbas

doi:10.1016/j.npep.2022.102291

Cited by 3 publications

(1 citation statement)

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“…119 Orexins are also associated with brain regions that regulate pain; 120 for example, orexins in the ventral tegmental area are associated with injurious responses. 121 Exogenously administered orexins have been shown to have analgesic effects in animal models. Orexins A and B, delivered by intracerebroventricular and intrathecal injection, enhance anti-injury perception in mice.…”

Section: Orexinsmentioning

confidence: 99%

The Underlying Mechanisms of Sleep Deprivation Exacerbating Neuropathic Pain

Zhu¹,

Huang²

2023

NSS

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Pain disrupts sleep, and sleep deprivation or interference can alter pain perception in animals and humans, for example by increasing sensitivity to pain. However, the mechanism by which sleep affects neuropathic pain remains unclear. In this review, we discuss the available evidence from the epidemiologic, clinical, and human, as well as laboratory studies. In previous studies, we have found that sleep deprivation affects various injurious systems, including opioids, dopaminergic, immune, orexins, hypothalamicpituitary-adrenal axis, and adenosine. At the same time, these systems play a crucial role in neuropathic pain regulation. In the complex interactions between these neurobiological systems, there may be potential regulatory pathways through which sleep deprivation amplifies neuropathic pain. Because of the impact sleep problems and neuropathic pain can have on the patients' quality of life, studying the link between sleep and neuropathic pain is important for neuropathic pain prevention and public health.

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Section: Orexinsmentioning

confidence: 99%