Antagonism of Tachykinin receptor 1 promotes Foxp3+ regulatory CD4 T cells and controls gut mucosal inflammation
Girdhari Lal,
Amrita Mishra,
Surojit Karmakar
et al.
Abstract:Neuroimmune communication of the enteric nervous system (ENS) in gut-associated lymphoid tissues helps to maintain the delicate balance between gut inflammation and tolerance. Substance P (SP) is a neuropeptide neurotransmitter produced by ENS and enteroendocrine cells, lymphocytes, gut macrophages, and brain neurons. SP binds to tachykinin receptors (TACRs, also known as neurokinin receptors). Inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS) patients are known to have altered TACRs expressi… Show more
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