Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice

Tang, Alexander; Code, Robert A.; Himes, Carol S.

doi:10.1016/0014-2999(93)90219-8

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…According to some reports, there may be some correlation between reduction in spontaneous motility and sedative activity [31], generally attributed to a reduced CNS excitability [32]. In this study, both TTE and the fraction 80S lowered spontaneous motility, increased (dose-dependently) pentobarbitone-induced sleeping time, reduced normal body temperature and also produced respiratory depression (with transient apnoea), similar to that of the benzodiazepines, which are also known to produce similar pharmacological effects [15,27,33]. Moreover, intraperitoneal administration of TTE and 80S significantly delayed the onset of tremor and convulsion induced by PTZ, even though no reduction in mortality could be observed with the test substances.…”

Section: Discussionsupporting

confidence: 57%

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An insight on the neuropharmacological activity of Telescopium telescopium– a mollusc from the Sunderban mangrove

Samanta

Kumar

Roy

et al. 2008

Fundamemntal Clinical Pharma

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The present study was carried out to evaluate the biological properties of the tissue extract of a marine snail Telescopium telescopium, collected from the coastal regions of West Bengal India. On extensive pharmacological screening, it was found that the biological extract of T. telescopium (TTE) produced significant central nervous system (CNS)-depressant activity as observed from the reduced spontaneous motility, potentiation of pentobarbitone induced sleeping time, hypothermia and respiratory depression with transient apnoea. The extract significantly decreased both residual curiosity and also muscle coordination. The fraction, obtained following saturation with 60-80% ammonium sulphate (80S), was also found to demonstrate predominant CNS-depressant activity. It was observed that both TTE and the 80S fraction significantly altered the brain noradrenaline and homovanillic acid levels without affecting the brain gamma amino butyric acid (GABA) concentration. Based on the present observations, it can be suggested that the CNS-depressant effects produced by TTE and 80S could be attributable to modified catecholamine metabolism in the brain.

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Section: Discussionsupporting

confidence: 57%

“…The brain tissue samples were then homogenized in 0.17 M perchloric acid (with dihydroxybenzylamine (DHBA) as internal standard in the range of 25 ng/mL) by Polytron homogenizer (Polytron, Littau-Lucerne, Switzerland). Homogenates were then centrifuged at 33…”

Section: Effect On Monoamine Neurotransmittermentioning

confidence: 99%

An insight on the neuropharmacological activity of Telescopium telescopium– a mollusc from the Sunderban mangrove

Samanta

Kumar

Roy

et al. 2008

Fundamemntal Clinical Pharma

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“…Further, in the rota rod test, riparin III, different from diazepam (2 mg/kg), had no effect on the motor co-ordination suggesting that the anxiolytic-like effect of the substance might not be exerted through peripheral neuromuscular blockade, but rather, elicited centrally. 31,32) It is well known that benzodiazepines act as anxiolytics (at low doses), anticonvulsants, and also produce sedation and a myorelaxant effect at higher doses, [33][34][35][36] thereby our group has used diazepam at 1 mg/kg in EPM and hole board tests and 2 mg/kg in open field and rota rod tests.…”

Section: Discussionmentioning

confidence: 99%

Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice

Melo

Monteiro

Leite

et al. 2006

Biological & Pharmaceutical Bulletin

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“…The intensity of reduction in exploratory behaviors in the treated animal groups which reflects the same line of action like the standard reference drug benzodiazipine, which act as a anxiolytics (at low doses), anticonvulsants, and also produce sedation and a myorelaxant effect at higher doses (Onaivi et al, 1992;Tang et al, 1993;Davies et al, 1994;Wolfman et al, 1993). The reduction in exploratory behavior in animals treated with EESM is similar with the action of other CNS depressant agents.…”

Section: Preliminary Phytochemical Testsmentioning

confidence: 92%

Central nervous system depressant and analgesic activities of Scutia myrtina in experimental animal model

R¹,

K²,

N³

2014

J. Med. Plants Res.

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The purpose of this study is to investigate the central nervous system (CNS) depressant and analgesic activities of the ethanol extract of Scutia myrtina (EESM) (Family: Rhamnaceae) in Swiss albino mice. To evaluate the CNS depressant activity by using the methods such as general behavior, exploratory behavior, muscle relaxant activity and phenobarbitone sodium-induced sleeping time were studied. Analgesic effect of EESM was evaluated in acetic acid induced writhing and hotplate tests. The results revealed that the EESM at the dose of 200 and 300 mg/kg caused a significant reduction in the spontaneous activity (general behavioral profile), remarkable decrease in exploratory behavioral pattern (Y-maze and head dip test), a reduction in muscle relaxant activity (rotarod and traction tests), and also significantly potentiated phenobarbitone sodium-induced sleeping time. The EESM also produced significant analgesic activity in both models at the dose of 200 and 300 mg/kg. Further, the EESM potentiated the morphine and aspirin induced analgesic in mice. The results suggest that EESM exhibit CNS depressant and analgesic activity in tested animal models.

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Antagonism of hypothermia produced by benzodiazepine-related compounds by U-78875 in mice

Cited by 11 publications

References 4 publications

An insight on the neuropharmacological activity of Telescopium telescopium– a mollusc from the Sunderban mangrove

An insight on the neuropharmacological activity of Telescopium telescopium– a mollusc from the Sunderban mangrove

Anxiolytic-Like Effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in Mice

Central nervous system depressant and analgesic activities of Scutia myrtina in experimental animal model

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