Antagonism of caffeine-induced seizures in mice by Ro15-1788

Vellucci, Sandra V.; Webster, Richard

doi:10.1016/0014-2999(84)90462-x

Cited by 89 publications

(33 citation statements)

References 15 publications

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“…Diazepam has been reported to be effective in reversing a disparate number of convulsants, including caffeine (21). Caffeine-induced seizures have also been reported to be reversed by the benzodiazepine antagonist, Ro 15-1788 (16). The findings of the present study confirm such observations.…”

Section: Discussionsupporting

confidence: 90%

“…However, caffeine and theophylline also exhibit moderate affinity (K i 300-500/μM) for benzodiazepine receptors labelled by [ 3 H]-diazepam (14). In addition, seizures induced by caffeine can be blocked by benzodiazepines, such as diazepam and Ro 15-1788 (15,16), raising the possibility that benzodiazepine receptors may mediate the convulsant actions of methylxanthines.…”

mentioning

confidence: 99%

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Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC)

Morgan

Deckert

Marangos³

et al. 1989

Life Sciences

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Section: Discussionsupporting

confidence: 90%

mentioning

confidence: 99%

Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC)

Morgan

Deckert

Marangos³

et al. 1989

Life Sciences

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“…The anticonvulsant testing method of Vellucci and Webster (1984), modified by Amabeoku and Chikuni (1993) and Mahomed and Ojewole (2006), was used to assess the antiseizure property of the plant extract (APE) in mice. Standard convulsant agents, pentylenetetrazole (PTZ, 90 mg/kg i.p.…”

Section: Methodsmentioning

confidence: 99%

Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm (‘African potato’) aqueous extract in mice

Ojewole

2007

Phytotherapy Research

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“…The method of Vellucci and Webster [24] as modified by Amabeoku and Kinyua [21], was used to evaluate the anticonvulsant activity of the leaf methanol extract of Tulbaghia violacea. The mice were acclimatized to their new environment by housing them singly in transparent perspex mice cages 30 min before the commencement of the experiments.…”

Section: Anticonvulsant Activity Assessmentmentioning

confidence: 99%

Investigation of Some Possible Mechanisms Involved in the Anticonvulsant Activity of Tulbaghia violacea Harv

Masoud¹

2017

JPP

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Even though Tulbaghia violacea has been used to treat and manage epilepsy in South Africa by traditional medicine practitioners, no evidence in any literature has shown any scientific scrutiny of the effectiveness of the plant species in therapy. This study was intended, therefore, to investigate the anticonvulsant effect of the leaf methanol extract of Tulbaghia violacea by studying its effect against tonic convulsion induced by either PTZ (pentylenetetrazole), bicuculline, picrotoxin, strychnine or NMDLA (N-methyl-DL-aspartic acid) in mice. Qualitative phytochemical analysis, acute toxicity and HPLC studies were also carried out on the plant species. Leaf methanol extract of Tulbaghia violacea, phenobarbitone, diazepam or muscimol significantly antagonised PTZ, bicuculline or picrotoxin-induced convulsion. Combined treatment of sub-effective doses of T. violacea and muscimol significantly antagonised tonic convulsion induced by PTZ. T. violacea or phenobarbitone significantly antagonised strychnine-induced tonic convulsion. T. violacea or LY233053 significantly antagonised NMDLA-elicited tonic convulsion. Phenytoin or DMSO (dimethylsulfoxide) did not significantly affect the tonic convulsion produced by PTZ, bicuculline, picrotoxin, strychnine or NMDLA. The phytochemical qualitative analysis of the plant species showed the presence of alkaloids, saponins, reducing sugars, flavonoids, cardiac glycosides, triterpene steroids, quinones and tannins. The LD50 value obtained following oral administration of the plant extract was over 4000 mg/kg. The data in the present study indicate that the leaf methanol extract of T. violacea has anticonvulsant activity which is probably underpinned by GABAergic, glutaminergic and glycinergic mechanisms.

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Antagonism of caffeine-induced seizures in mice by Ro15-1788

Cited by 89 publications

References 15 publications

Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC)

Potent convulsant actions of the adenosine receptor antagonist, xanthine amine congener (XAC)

Anticonvulsant activity of Hypoxis hemerocallidea Fisch. & C. A. Mey. (Hypoxidaceae) corm (‘African potato’) aqueous extract in mice

Investigation of Some Possible Mechanisms Involved in the Anticonvulsant Activity of Tulbaghia violacea Harv

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