ANT(9)-Ic, a Novel Chromosomally Encoded Aminoglycoside Nucleotidyltransferase from Brucella intermedia

Sheng, Xiusheng; Lü, Wei; Li, Aifang; Lü, Jing; Song, Chunhan; Xu, Jiefeng; Dong, Youming; Fu, Chu-Li; Lin, Xiangmin; Zhu, Mei; Bao, Qiyu; Li, Kewei

doi:10.1128/spectrum.00620-23

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…ant(9)-la is the gene responsible for the expression of aminoglycoside O-nucleotidyltransferase which catalyzes the adenylation of an AMP group from a substrate to the aminoglycoside molecule to make it inactive and convey specific resistance to spectinomycin [13,14].…”

Section: Antimicrobial Resistance Genesmentioning

confidence: 99%

Epidemiology of Antimicrobial Resistance Genes in Staphyloccocus aureus Isolates from a Public Database in a One Health Perspective—Sample Characteristics and Isolates’ Sources

et al. 2023

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Staphylococcus aureus is considered one of the most widespread bacterial pathogens for both animals and humans, being the causative agent of various diseases like food poisoning, respiratory tract infections, nosocomial bacteremia, and surgical site and cardiovascular infections in humans, as well as clinical and subclinical mastitis, dermatitis, and suppurative infections in animals. Thanks to their genetic flexibility, several virulent and drug-resistant strains have evolved mainly due to horizontal gene transfer and insurgence of point mutations. Infections caused by the colonization of such strains are particularly problematic due to frequently occurring antibiotic resistance, particulary methicillin-resistant S. aureus (MRSA), and are characterized by increased mortality, morbidity, and hospitalization rates compared to those caused by methicillin-sensitive S. aureus (MSSA). S. aureus infections in humans and animals are a prime example of a disease that may be managed by a One Health strategy. In fact, S. aureus is a significant target for control efforts due to its zoonotic potential, the frequency of its illnesses in both humans and animals, and the threat posed by S. aureus antibiotic resistance globally. The results of an epidemiological analysis on a worldwide public database (NCBI Pathogen Detection Isolate Browser; NPDIB) of 35,026 S. aureus isolates were described. We considered the diffusion of antibiotic resistance genes (ARGs), in both human and animal setting, and the results may be considered alarming. The result of this study allowed us to identify the presence of clusters with specific ARG patterns, and that these clusters are associated with different sources of isolation (e.g., human, non-human).

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Section: Antimicrobial Resistance Genesmentioning

confidence: 99%

Epidemiology of Antimicrobial Resistance Genes in Staphyloccocus aureus Isolates from a Public Database in a One Health Perspective—Sample Characteristics and Isolates’ Sources

et al. 2023

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The Antibiotic Susceptibility of Brucella spp. Isolated from Human Samples: A Systematic Review and Meta-Analysis

Darvishi,

Nazer,

Hashemi Rafsanjani

et al. 2023

Iran J Med Microbiol

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Countering Aminoglycoside Modifying Enzymes

Tiwari,

Nain,

Gaur

et al. 2024

Advances in Medical Technologies and Clinical Practice

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Aminoglycosides are a group of broad-spectrum antibiotics that progress the formation of antibiotic-resistant strains. As many microbes have the capability to encounter them with their diverse defense mechanisms, this shed light on the vulnerability of aminoglycosides as antibiotics. Consistent use of numerous antibiotics has resulted in multi drug resistant (MDR) strains, becoming the most sensitive and high-priority concern. The microbial resistance against aminoglycosides is due to Aminoglycoside modifying enzymes (AMEs), which improvise the chemical structure of aminoglycosides and cease the ability of the antibiotic to bind to its natural target site. Evolutionary processes make AMEs capable of resisting most natural and semi-synthetic antibiotics. Consequently, constructing AMEs inhibition strategies may block the modification of aminoglycosides by AMEs to counter the problem of MDR bacteria. This chapter provides insight into understanding aminoglycosides and AMEs interactions, which play a pivotal role in developing inhibitory strategies. It may be helpful to counter the threat of MDR.

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ANT(9)-Ic, a Novel Chromosomally Encoded Aminoglycoside Nucleotidyltransferase from Brucella intermedia

Abstract: The emergence, evolution, and worldwide spread of antibiotic resistance present a significant global public health crisis. For aminoglycoside antibiotics, enzymatic drug modification is the most common mechanism of resistance.

Cited by 3 publications

References 26 publications

Epidemiology of Antimicrobial Resistance Genes in Staphyloccocus aureus Isolates from a Public Database in a One Health Perspective—Sample Characteristics and Isolates’ Sources

Epidemiology of Antimicrobial Resistance Genes in Staphyloccocus aureus Isolates from a Public Database in a One Health Perspective—Sample Characteristics and Isolates’ Sources

The Antibiotic Susceptibility of Brucella spp. Isolated from Human Samples: A Systematic Review and Meta-Analysis

Countering Aminoglycoside Modifying Enzymes

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