Anshen Dingzhi prescription in the treatment of PTSD in mice: Investigation of the underlying mechanism from the perspective of hippocampal synaptic function

Yang, Shaojie; Yan, Qingzhi; Wang, Juan; Ji, Manman; Xie, Pan; Zhu, Aizhi; Tan, Bei; Wang, Xuncui; Zhu, Guoqi

doi:10.1016/j.phymed.2022.154139

Cited by 23 publications

(15 citation statements)

References 63 publications

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“…Interestingly, BDNF regulating synaptic transmission participants in fear learning in PTSD model (Ni et al, 2020) and the low level of BDNF correlates with the development of PTSD (Lu et al, 2021). In our previous studies (Wang et al, 2022; Yang et al, 2019; Yang et al, 2022), we reported that either 7,8‐dihydroxyflavone or a famous Xin'an prescription‐Anshen Dingzhi prescription could rescue the synaptic deficit in PTSD model likely through promoting BDNF/TrkB.…”

Section: Introductionmentioning

confidence: 89%

Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling

Zhang

Yang

et al. 2022

Phytotherapy Research

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Chronic traumatic stress results in various psychiatric disorders, especially posttraumatic stress disorder (PTSD). Previous study demonstrated that curculigoside (CUR) a component of Rhizoma Curculiginis prevented fear extinction and stress‐induced depression‐like behaviors. However, its effects on PTSD and the mechanisms are still not completely clear. In this study, we observed typical PTSD‐like phenotypes, synaptic deficit, and reduction of BDNF/TrkB signaling pathway in mice receiving modified single prolonged stress and electrical stimulation (SPS&S). By contrast, systemic administration of CUR blocked PTSD‐like phenotypes and synaptic deficits, including reduction of BDNF/TrkB signaling pathway, GluA1 and Arc expression. Importantly, CUR reversed the impairment of PKA signaling pathway elicited by PTSD. We further confirmed that the effects of CUR on synaptic function were through PKA signaling pathway, as H‐89, an inhibitor of PKA blocked the effect of CUR on behavioral changes and BDNF/TrkB signaling pathway. Thereafter, we verified that CUR on synaptic function were through PKA pathway using direct intracerebral injection of CUR and H‐89. Direct intracerebral injection of CUR activated PKA/CREB/BDNF/TrkB, which was blocked by H‐89. Additionally, the docking results showed high binding energies of CUR with A2AR, AC, PRKACA, and PRKAR1A, which might indicate that CUR functions through regulating PKA signaling pathway. In conclusion, CUR prevented the behavioral changes and hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling.

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Section: Introductionmentioning

confidence: 89%

Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling

Zhang

Yang

et al. 2022

Phytotherapy Research

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“…4 Oxidative Medicine and Cellular Longevity [59]. Our team found that activation of the BDNF/TrkB signaling pathway and regulation of NMDAR and α-amino-3hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) expression could improve synaptic plasticity in neurons [9]. Thus, activation of signaling pathways such as PI3K-AKT-mTOR and BDNF/TrkB is an effective means to protect neurons.…”

Section: Potential Mechanisms Underlying Thementioning

confidence: 99%

“…MPTP treatment has been shown to induce autophagy in dopaminergic neurons and reduce neuronal viability, while insulin-like growth factor-1 (IGF-1) can inhibit MPTP-induced dopaminergic neuronal damage through activation of the IGF-1 receptor/PI3K-Akt-mTOR signaling pathway and G-protein-coupled ER 1 [ 59 ]. Our team found that activation of the BDNF/TrkB signaling pathway and regulation of NMDAR and α -amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor (AMPAR) expression could improve synaptic plasticity in neurons [ 9 ]. Thus, activation of signaling pathways such as PI3K-AKT-mTOR and BDNF/TrkB is an effective means to protect neurons.…”

Section: Potential Mechanisms Underlying the Effects Of Acupuncture O...mentioning

confidence: 99%

“…Synaptic plasticity in the hippocampal CA1 region is closely related to learning and memory [6]. In addition to playing an important role in the development and formation of neural circuits, synaptic plasticity is also closely related to the development of various neurogenic and psychogenic diseases [7][8][9]. Impairment of hippocampal synaptic plasticity in CI, including AD and VCDs, has been extensively reported [10,11].…”

Section: Introductionmentioning

confidence: 99%

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Acupuncture Interventions for Alzheimer’s Disease and Vascular Cognitive Disorders: A Review of Mechanisms

Yang

Wang

et al. 2022

Oxidative Medicine and Cellular Longevity

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Cognitive impairment (CI) related to Alzheimer’s disease (AD) and vascular cognitive disorders (VCDs) has become a key problem worldwide. Importantly, CI is a neuropsychiatric abnormality mainly characterized by learning and memory impairments. The hippocampus is an important brain region controlling learning and memory. Recent studies have highlighted the effects of acupuncture on memory deficits in AD and VCDs. By reviewing the literature published on this topic in the past five years, the present study intends to summarize the effects of acupuncture on memory impairment in AD and VCDs. Focusing on hippocampal synaptic plasticity, we reviewed the mechanisms underlying the effects of acupuncture on memory impairments through regulation of synaptic proteins, AD characteristic proteins, intestinal microbiota, neuroinflammation, microRNA expression, orexin system, energy metabolism, etc., suggesting that hippocampal synaptic plasticity may be the common as well as the core link underlying the above mechanisms. We also discussed the potential strategies to improve the effect of acupuncture. Additionally, the effects of acupuncture on synaptic plasticity through the regulation of vascular–glia–neuron unit were further discussed.

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“…Hematoxylin and eosin staining also revealed that ADP has neuroprotective effects in the hippocampal CA1 region. Furthermore, researchers found that ADP reduced PTSD-like behaviors by regulating synaptic protein levels [ 123 ].…”

Section: Effects Of Herbal Medicines On Ptsd Via Amelioration Of Dist...mentioning

confidence: 99%

Nutraceutical Interventions for Post-Traumatic Stress Disorder in Animal Models: A Focus on the Hypothalamic–Pituitary–Adrenal Axis

2022

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Post-traumatic stress disorder (PTSD) occurs after exposure to traumatic events and is characterized by overwhelming fear and anxiety. Disturbances in the hypothalamic–pituitary–adrenal (HPA) axis are involved in the pathogenesis of mood disorders, including anxiety, PTSD, and major depressive disorders. Studies have demonstrated the relationship between the HPA axis response and stress vulnerability, indicating that the HPA axis regulates the immune system, fear memory, and neurotransmission. The selective serotonin reuptake inhibitors (SSRIs), sertraline and paroxetine, are the only drugs that have been approved by the United States Food and Drug Administration for the treatment of PTSD. However, SSRIs require long treatment times and are associated with lower response and remission rates; therefore, additional pharmacological interventions are required. Complementary and alternative medicine therapies ameliorate HPA axis disturbances through regulation of gut dysbiosis, insomnia, chronic stress, and depression. We have described the cellular and molecular mechanisms through which the HPA axis is involved in PTSD pathogenesis and have evaluated the potential of herbal medicines for PTSD treatment. Herbal medicines could comprise a good therapeutic strategy for HPA axis regulation and can simultaneously improve PTSD-related symptoms. Finally, herbal medicines may lead to novel biologically driven approaches for the treatment and prevention of PTSD.

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Anshen Dingzhi prescription in the treatment of PTSD in mice: Investigation of the underlying mechanism from the perspective of hippocampal synaptic function

Cited by 23 publications

References 63 publications

Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling

Curculigoside rescues hippocampal synaptic deficits elicited by PTSD through activating cAMP‐PKA signaling

Acupuncture Interventions for Alzheimer’s Disease and Vascular Cognitive Disorders: A Review of Mechanisms

Nutraceutical Interventions for Post-Traumatic Stress Disorder in Animal Models: A Focus on the Hypothalamic–Pituitary–Adrenal Axis

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