Ansa Pancreatica: A Rare Culprit in Recurrent Acute Pancreatitis

Abstract

Ansa pancreatica is a rare anatomical variation of the pancreatic duct system, characterized by a reversed S-shaped loop that connects the main pancreatic duct to the minor papilla. Its clinical significance, particularly with recurrent acute pancreatitis, has been a subject of interest, but remains poorly understood due to the rarity of reported cases. We report the case of a 34-year-old female with a history of multiple episodes of acute pancreatitis, diagnosed with ansa pancreatica using magnetic resonance cholangiopancreatography (MRCP). The patient presented with severe epigastric pain radiating to the back, accompanied by vomiting and nausea. Laboratory findings revealed elevated serum amylase and lipase levels. MRCP imaging identified the ansa pancreatica, showing a distinct looping ductal variant terminating near the minor papilla. The patient underwent successful endoscopic treatment with significant improvement in symptoms and no recurrence of pancreatitis at follow-up. In this case, the presence of ansa pancreatica underscores the variant's potential role in predisposing individuals to recurrent episodes of acute pancreatitis. The literature review highlights the anatomical description of ansa pancreatica and its speculated pathophysiological mechanism leading to pancreatitis, primarily due to impaired pancreatic juice drainage. Despite its rarity, recognizing ansa pancreatica is crucial for the appropriate management of idiopathic recurrent pancreatitis, especially in cases where conventional causes are absent. This case report and literature review emphasize the importance of considering ansa pancreatica in the differential diagnosis of recurrent acute pancreatitis. Further research is needed to elucidate the exact mechanism by which this anatomical variant contributes to pancreatitis and to explore potential therapeutic interventions. Awareness and early detection of ansa pancreatica can lead to targeted treatments, reducing the morbidity associated with recurrent pancreatitis episodes.