ANS: Adjusted Neighborhood Scoring to improve assessment of gene signatures in single-cell RNA-seq data
Laure Ciernik,
Agnieszka Kraft,
Florian Barkmann
et al.
Abstract:In the field of single-cell RNA sequencing (scRNA-seq), gene signature scoring is integral for pinpointing and characterizing distinct cell populations. However, challenges arise in ensuring the robustness and comparability of scores across various gene signatures and across different batches and conditions. Addressing these challenges, we evaluated the stability of established methods such as Scanpy, UCell, and JASMINE in the context of scoring cells of different types and states. Additionally, we introduced … Show more
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