ANRIL as a prognostic biomarker in colon pre-cancerous lesion detection via non-invasive sampling

Sadri, Shadi; Rejali, Leili; Hadizadeh, Mahrooyeh; Aghdaei, Hamid Asadzadeh; Young, Chris; Nazemalhosseini‐Mojarad, Ehsan; Zali, Mohammad Reza; Bonab, Maziar Ashrafian

doi:10.1266/ggs.21-00102

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…This review summarizes common epigenetic biomarkers for CRC (see Figure 1 ), including the methylation of VIM, NDRG4, BMP3, SDC2, SEPT2, SEPT9 genes, and the high expression of miR-21, miR-135b-5p, miR-92a-1, ANRIL [ 215 ]. However, their clinical diagnostic results for early CRC screening and prognosis still show individual variability.…”

Section: Summary and Future Perspectivementioning

confidence: 99%

Epigenetic Alteration in Colorectal Cancer: Potential Diagnostic and Prognostic Implications

Cao,

Tian,

Deng

et al. 2024

IJMS

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Colorectal cancer (CRC), a prevalent malignant tumor of the digestive system, ranks as the third and second in global incidence and mortality, respectively, in 2020, with 1.93 million new cases (≈10% of all cancers). There are 940,000 deaths (≈9.4% of all cancers), and the incidence of CRC in younger patients (under 50 years of age) has become a new trend. The pathogenesis of CRC is primarily attributed to a series of genetic and epigenetic abnormalities within normal colonic epithelial cells, coupled with the reshaping of the tumor microenvironment in the surrounding stroma. This process leads to the transformation of colorectal adenomas into invasive adenocarcinomas. Although genetic changes are known to be the primary driving force in the occurrence and progression of CRC, recent research indicates that epigenetic regulation serves as a crucial molecular marker in cancer, playing a significant role in the pathological and physiological control of interactions between genetics and the environment. This review discusses the current global epidemiology of CRC, its risk factors, and preventive treatment strategies. The current study explores the latest advancements in the epigenetic regulation of CRC, including DNA methylation, histone modifications, and non-coding RNAs (ncRNAs). These developments hold potential as screening tools, prognostic biomarkers, and therapeutic targets for CRC.

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Section: Summary and Future Perspectivementioning

confidence: 99%

Epigenetic Alteration in Colorectal Cancer: Potential Diagnostic and Prognostic Implications

Cao,

Tian,

Deng

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…Likewise, MIR31HG and WASIR2 demonstrated particular consequences as prognostic indicators for stage II CRC [ 112 ]. Decreased expression of ANRIL and increased expression of BANCR have also been confirmed as prognostic and early diagnosis of CRC [ 113 ]. Inhibiting epidermal growth factor receptor (EGFR) signaling through suppressing the prognostic factor linc-ROR leads to a decrease in aggression, proliferation, and migration in CRC [ 114 ].…”

Section: Introductionmentioning

confidence: 99%

Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers

Zabeti Touchaei,

Vahidi,

Samadani

2024

Clin Exp Med

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Colorectal cancer (CRC) and gastric cancer (GC) are major contributors to cancer-related mortality worldwide. Despite advancements in understanding molecular mechanisms and improved drug treatments, the overall survival rate for patients remains unsatisfactory. Metastasis and drug resistance are major challenges contributing to the high mortality rate in both CRC and GC. Recent research has shed light on the role of long noncoding RNAs (lncRNAs) in the development and progression of these cancers. LncRNAs regulate gene expression through various mechanisms, including epigenetic modifications and interactions with microRNAs (miRNAs) and proteins. They can serve as miRNA precursors or pseudogenes, modulating gene expression at transcriptional and post-transcriptional levels. Additionally, circulating lncRNAs have emerged as non-invasive biomarkers for the diagnosis, prognosis, and prediction of drug therapy response in CRC and GC. This review explores the intricate relationship between lncRNAs and CRC/GC, encompassing their roles in cancer development, progression, and chemoresistance. Furthermore, it discusses the potential of lncRNAs as therapeutic targets in these malignancies. The interplay between lncRNAs, miRNAs, and tumor microenvironment is also highlighted, emphasizing their impact on the complexity of cancer biology. Understanding the regulatory landscape and molecular mechanisms governed by lncRNAs in CRC and GC is crucial for the development of effective diagnostic and prognostic biomarkers, as well as novel therapeutic strategies. This review provides a comprehensive overview of the current knowledge and paves the way for further exploration of lncRNAs as key players in the management of CRC and GC. Graphical Abstract

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Non-coding RNAs in Precursor Lesions of Colorectal Cancer: Their Role in Cancer Initiation and Formation

Mohammadpour,

Noukabadi,

Esfahani

et al. 2024

CMM

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Colorectal cancer (CRC) is one of the world's most common types of malignancy. The proliferation of precancerous lesions causes this type of cancer. Two distinct pathways for CRC carcinogenesis have been identified: the conventional adenoma-carcinoma pathway and the serrated neoplasia pathway. Recently, evidence has demonstrated the regulatory roles of noncoding RNAs (ncRNAs) in the initiation and progression of precancerous lesions, especially in the adenoma-carcinoma pathway and serrated neoplasia pathway. By expanding the science of molecular genetics and bioinformatics, several studies have identified dysregulated ncRNAs that function as oncogenes or tumor suppressors in cancer initiation and formation by diverse mechanisms via intracellular signaling pathways known to act on tumor cells. However, many of their roles are still unclear. This review summarizes the functions and mechanisms of ncRNAs (such as long non-coding RNAs, microRNAs, long intergenic non-coding RNAs, small interfering RNAs, and circRNAs) in the initiation and formation of precancerous lesions.

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ANRIL as a prognostic biomarker in colon pre-cancerous lesion detection via non-invasive sampling

Cited by 4 publications

References 36 publications

Epigenetic Alteration in Colorectal Cancer: Potential Diagnostic and Prognostic Implications

Epigenetic Alteration in Colorectal Cancer: Potential Diagnostic and Prognostic Implications

Decoding the regulatory landscape of lncRNAs as potential diagnostic and prognostic biomarkers for gastric and colorectal cancers

Non-coding RNAs in Precursor Lesions of Colorectal Cancer: Their Role in Cancer Initiation and Formation

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