ANRIL: A Regulator of VEGF in Diabetic Retinopathy

Thomas, Anoop; Feng, Biao; Chakrabarti, Subrata

doi:10.1167/iovs.16-20569

Cited by 149 publications

(170 citation statements)

References 68 publications

(87 reference statements)

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“…McArthur et al demonstrated that ANRIL regulated the expression of VEGF through recruiting PRC2 or p300 and regulating the expression of miR‐200b in a rat model of diabetes mellitus . Thomas et al found that ANRIL upregulated the expression of VEGF through interaction with P300, PRC2 or miR‐200b, which resulted in vascular endothelial injury …”

Section: Resultsmentioning

confidence: 99%

ANRIL and atherosclerosis

Chen

Guo

et al. 2019

J Clin Pharm Ther

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What is known and objective The 3.8‐kb‐long antisense non‐coding RNA at the INK4 locus (ANRIL) is transcribed from the short arm of human chromosome 9 on P21 and is associated with malfunction of the vascular endothelium, vascular smooth muscle cell (VSMC) proliferation/migration/senescence/apoptosis, mononuclear cell adhesion and proliferation, glycolipid metabolism disorder and DNA damage. Hence, ANRIL plays an important role in atherogenesis. Moreover, genome‐wide association studies (GWAS) have identified ANRIL as a biomarker that is closely related to coronary heart disease (CHD). The objective of this review was to discuss the pathological mechanism of ANRIL in atherosclerotic development and its significance as a predictor of cardiovascular disease. Methods Review of the PubMed, EMBASE and Cochrane databases for articles demonstrating the roles of ANRIL in the development of atherosclerotic diseases. Results and discussion The abnormal expression of ANRIL is linked to vascular endothelium injury; the proliferation, migration, senescence and apoptosis of VSMCs; mononuclear cell adhesion and proliferation; glycolipid metabolism disorder; DNA damage; and competing endogenous RNAs. Moreover, ANRIL accelerates the progression of CHD by regulating its single nucleotide polymorphisms (SNPs). What is new and conclusion Considering that ANRIL accelerates atherosclerosis (AS) development and is a risk factor for CHD, it is reasonable for us to explore an efficacious ANRIL‐based therapy for AS in CHD.

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Section: Resultsmentioning

confidence: 99%

ANRIL and atherosclerosis

Chen

Guo

et al. 2019

J Clin Pharm Ther

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“…Guo, Hu, Hu, He, & Li, 2018), differentiation (Gao, Ge, Li, Zhou, & Xu, 2018), and chromosome inactivation (Yue & Ogawa, 2018 (Hu, Jiang, & Jiang, 2017). Besides, the importance of lncRNA ANRIL in other diseases, like atherosclerosis (Chi et al, 2017) and diabetic retinopathy (Thomas, Feng, & Chakrabarti, 2017), have also been gradually reported. In the current study, we found that the expression of lncRNA ANRIL was significantly elevated in response…”

Section: Discussionmentioning

confidence: 99%

Tanshinone IIA protects lens epithelial cells from H₂O₂‐induced injury by upregulation of lncRNA ANRIL

Wang²,

Zhang

et al. 2019

Journal Cellular Physiology

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Tanshinone IIA is a lipophilic diterpene extracted from the Salvia miltiorrhiza bunge, possessing antiapoptotic and antioxidant activities. The purpose of this study was to explore the effects of Tanshinone IIA on age‐related nuclear cataract. Human lens epithelial cell line SRA01/04 was subjected to H 2O 2 to mimic a cell model of cataract. Cell Counting Kit‐8 assay, flow cytometer, and reactive oxygen species (ROS) detection were performed to evaluate the effect of Tanshinone IIA pretreatment on SRA01/04 cells injured by H 2O 2. Besides, the real‐time quantitative polymerase chain reaction was used to assess the expression of long noncoding RNA (lncRNA) antisense noncoding RNA in the INK4 locus (ANRIL). Western blot analysis was performed to detect the expression of core proteins involved in cell survival and nuclear factor‐κB (NF‐κB) pathway. H 2O 2 significantly decreased SRA01/04 cells viability, whereas increased apoptosis and ROS generation. This phenomenon was coupled with the upregulated p53, p21, Bax, cleaved caspase‐3, and the downregulated cyclinD1, CDK4, and Bcl‐2. Tanshinone IIA pretreatment protected SRA01/04 cells against H 2O 2‐induced injury. In the meantime, the expression of lncRNA ANRIL was upregulated by Tanshinone IIA. And, the protective effects of Tanshinone IIA on H 2O 2‐stimulated SRA01/04 cells were abolished when lncRNA ANRIL was silenced. Moreover, the elevated expression of lncRNA ANRIL induced by Tanshinone IIA was abolished by BAY 11‐7082 (an inhibitor of NF‐κB). To conclude, Tanshinone IIA protects SRA01/04 cells from apoptosis triggered by H 2O 2. Tanshinone IIA confers its protective effects possibly via modulation of NF‐κB signaling and thereby elevating the expression of lncRNA ANRIL.

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“…Thomas et al demonstrated for the first time that antisense noncoding RNA (ANRIL) regulates vascular endothelial growth factor (VEGF) expression and function in diabetic retinopathy. This regulation is mediated by p300, miR200b, and EZH2 of the PRC2 complex . Arnes et al indicated that β‐cell long intergenic noncoding RNA 1 (βlinc1), a conserved lncRNA, is necessary for the specification and function of insulin‐producing β cells through the coordinated regulation of a number of islet‐specific transcription factors located in the genomic vicinity of βlinc1 .…”

Section: The Possible Mechanism Of Lncrna In Dcmmentioning

confidence: 99%

“…This regulation is mediated by p300, miR200b, and EZH2 of the PRC2 complex. 86 Arnes et al indicated that β-cell long intergenic noncoding RNA 1 (βlinc1), a conserved lncRNA, is necessary for the specification and function of insulin-producing β cells through the coordinated regulation of a number of islet-specific transcription factors located in the genomic vicinity of βlinc1. 74 Reddy et al suggested that lncRNA E330013P06 (E33) can serve as novel therapeutic targets to attenuate inflammation and atherogenic potential of macrophages and concomitant diabetes complications.…”

Section: Lncrnas Associate With Dysfunction Of Islet β Cellmentioning

confidence: 99%

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Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?

Luo

Liu

et al. 2018

Diabetes Metabolism Res

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Diabetic cardiomyopathy (DCM) can cause extensive necrosis of the heart muscle by metabolic disorders and microangiopathy, with subclinical cardiac dysfunction, and eventually progress to heart failure, arrhythmia, and cardiogenic shock; severe patients may even die suddenly. Long noncoding RNAs (lncRNAs) are a class of nonprotein-coding RNAs longer than 200 nucleotides. They have critical roles in various biological processes, including gene expression regulation, genomic imprinting, nuclear-cytoplasmic trafficking, RNA splicing, and translational control. Recent studies indicated that lncRNAs extensively participate in the development of diverse cardiac diseases, such as cardiac ischaemia, hypertrophy, and heart failure. Little is known about lncRNA in DCM. In this review, we summarize the current literature on lncRNAs in DCM studies, aiming to provide new methods for DCM's future prevention and treatment strategies.

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ANRIL: A Regulator of VEGF in Diabetic Retinopathy

Abstract: Our results demonstrate for the first time that ANRIL regulates VEGF expression and function in diabetic retinopathy. This regulation is mediated by p300, miR200b, and EZH2 of the PRC2 complex.

Cited by 149 publications

References 68 publications

ANRIL and atherosclerosis

ANRIL and atherosclerosis

Tanshinone IIA protects lens epithelial cells from H₂O₂‐induced injury by upregulation of lncRNA ANRIL

Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?

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ANRIL: A Regulator of VEGF in Diabetic Retinopathy

Abstract: Our results demonstrate for the first time that ANRIL regulates VEGF expression and function in diabetic retinopathy. This regulation is mediated by p300, miR200b, and EZH2 of the PRC2 complex.

Cited by 149 publications

References 68 publications

ANRIL and atherosclerosis

ANRIL and atherosclerosis

Tanshinone IIA protects lens epithelial cells from H2O2‐induced injury by upregulation of lncRNA ANRIL

Long noncoding RNAs: A new player in the prevention and treatment of diabetic cardiomyopathy?

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Tanshinone IIA protects lens epithelial cells from H₂O₂‐induced injury by upregulation of lncRNA ANRIL