Anp32e protects against accumulation of H2A.Z at Sox motif containing promoters during zebrafish gastrulation
Fabian N. Halblander,
Fanju W. Meng,
Patrick J. Murphy
Abstract:Epigenetic regulation of chromatin states is crucial for proper gene expression programs and progression during development, but precise mechanisms by which epigenetic factors influence differentiation remain poorly understood. Here we find that the histone variant H2A.Z accumulates at Sox motif-containing promoters during zebrafish gastrulation while neighboring genes become transcriptionally active. These changes coincide with reduced expression ofanp32e, the H2A.Z histone removal chaperone, suggesting that … Show more
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