Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system

Golonko, Aleksandra; Pienkowski, Tomasz; Świsłocka, Renata; Łaźny, Ryszard; Roszko, Marek; Lewandowski, W.

doi:10.1016/j.ejmech.2019.01.044

Cited by 21 publications

(14 citation statements)

References 169 publications

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“…Antioxidants possess great potential as drugs suitable for the treatment of various diseases related to oxidative stress. In particular, the use of compounds containing phenol structural moiety in the treatment of Alzheimer's disease [32][33][34][35][36], Parkinson´s disease [37][38][39], Huntington´s disease [40,41], and cancer [42][43][44][45] have been extensively studied in the last two years. Their structural diversity provides many possibilities for the design and synthesis of new, highly effective agents.…”

Section: Introductionmentioning

confidence: 99%

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

et al. 2020

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A series of 1,3,5-triazine analogues, incorporating aminobenzene sulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step-by-step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and EC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest concentration 1 × 10−4 M, the %inhibition activity values at 0 min were comparable with both standards at least for 10 compounds. After 60 min, compounds 5, 6, 13, and 25 showed nearly twice %inhibition (73.44–87.09%) in comparison with the standards (Trolox = 41.49%; ASA = 31.07%). Values of EC50 at 60 min (17.16–27.78 μM) were 5 times lower for compounds 5, 6, 13, and 25 than EC50 of both standards (trolox = 178.33 μM; ASA = 147.47 μM). Values of EC50 correlated with %inhibition activity. Based on these results, the presented 1,3,5-triazine analogues have a high potential in the treatment of illnesses caused or related to oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

et al. 2020

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“…The phytochemical profile of the jurubeba fruit extract consists of phenolic compounds, vitamin E, and carotenoids. Polyphenols can act via noncovalent interaction with cellular proteins promoting the inhibition of prooxidant enzymes and diminishing DNA damage and lipid peroxidation as well as inhibition of ROS-dependent signal transduction [28]. In our phytochemical profile, caffeic acid is the major phenolic compound, but we also identified chlorogenic acid and 4…”

Section: Discussionmentioning

confidence: 75%

“…Oxidative Medicine and Cellular Longevity Moreover, the authors have shown the apoptotic effect by cleavages of caspase-3 and poly (ADP-ribose) polymerase and activation of Bax protein [29]. In parallel, Abou-Hashem et al showed the apoptotic effect of chlorogenic acid via cell cycle arrest at the sub-G0 phase and DNA fragmentation [30], whereas quercetin can induce apoptosis through proteasome inhibition such as the 20S and 26S proteasome in Jurkat T cells and accumulation of polyubiquitinated proteins [28].…”

Section: Discussionmentioning

confidence: 99%

Hydroethanolic Extract of Solanum paniculatum L. Fruits Modulates ROS and Cytokine in Human Cell Lines

Ferraz

Sussulini

Garcia

et al. 2020

Oxidative Medicine and Cellular Longevity

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Solanum paniculatum L. or popularly known as “jurubeba” is an herbal medicinal plant. A few studies have investigated its biological effects; however, research aimed at elucidating the redox balance effects from its fruits has not been reported so far. ROS interplays in various fields of medicine such as chemotherapy. Here, we evaluated antioxidant and inflammatory activities of the hydroethanolic extract of Solanum Paniculatum L. (HESPL) fruits in breast cancer cells, as well as its phytochemical profile. The antioxidant profile (carotenoids and phenolic compounds) was obtained by HPLC-DAD-UV and HPLC-APCI-MS. Cancer cell lines and human vein endothelial cells (HUVECs) were cultivated and treated with 1.87-30 μg/mL of HESPL for 24 hrs. Cytotoxicity, oxidative, and inflammation biomarkers were evaluated. The dose of 30 μg/mL of the HESPL extract presented cytotoxicity in the MCF-7 cell line. However, for MDA-MB-231, the cytotoxicity was observed in the dose of 1.87 g/mL. The 1.87 μg/mL and 3.75 μg/mL doses decreased the concentration of IL-6 in MCF-7 cells. In the MDA-MB-231 cells, the HESPL did not decrease the IL-6 concentration; however, in the doses of 15 and 30 μg/mL, an increase in this parameter was observed. The HESPL increased IL-1β concentration in HUVECs. The ROS level in MCF-7 was elevated only at the 30 μg/ml dose. Regarding MDA-MB-231, HESPL promoted increased ROS levels at all doses tested. HUVEC showed no increase in ROS under any dose. HESPL treatment may modulate cytotoxicity, ROS, and cytokine levels due to its phytochemical profile, and it has shown an antioxidant or anti-inflammatory effect.

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“…It has been suggested that natural antioxidants have ability to change the metabolism of certain carcinogens (77). Some reports indicate that they decreased microsomal metabolism to DNA-binding metabolites and epoxidation, enhanced the formation of readily conjugated and excreted metabolites and increased both the activity and level of GSH and glucuronide conjugating enzyme (76).…”

Section: Phenolic Compounds and Biological Effectsmentioning

confidence: 99%

Plant-food-derived bioactives: Key health benefits and current nanosystems as a strategy to enhance their bioavailability

Salehi

Rodrigues

Karaça

et al. 2020

Cell Mol Biol (Noisy-le-grand)

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Natural products interest is gradually increasing worldwide. Plant-food-derived bioactives have a long history of use as a good source of ingredients for valuable medical usages. Plant-based foods consist of micro and macronutrients, and bioactive components, with health-promoting benefits. The handling of complex mixtures of plants has been methodically switched by therapies using a single isolated substance. The delivery of bioactive molecules in nanosystems is enhancing their bioavailability, it is much safer and cost-effective. However, there are many challenges in combining bioactive substances in nanocarrier materials.A discussion related with nanocarriers will be done in this review.

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Another look at phenolic compounds in cancer therapy the effect of polyphenols on ubiquitin-proteasome system

Cited by 21 publications

References 169 publications

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

Antioxidative Activity of 1,3,5-Triazine Analogues Incorporating Aminobenzene Sulfonamide, Aminoalcohol/Phenol, Piperazine, Chalcone, or Stilbene Motifs

Hydroethanolic Extract of Solanum paniculatum L. Fruits Modulates ROS and Cytokine in Human Cell Lines

Plant-food-derived bioactives: Key health benefits and current nanosystems as a strategy to enhance their bioavailability

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