Another lactate dehydrogenase IgA complex in serum.

Immunoglobulin Complexed AST (“Macro‐AST”) in an Asymptomatic Child with Persistent Hypertransaminasemia

“…Our biochemical studies revealed that in this patient , AST binds to immunoglobulin G to form a complex that is not easily cleared from plasma. Thus far, this probably harmless phenomenon has been described for several enzymes (13)(14)(15): amylase, lactate dehydrogenase, creatine kinase, and alkaline phosphatase, in addition to AST. There appear to be nine cases of immunoglobulin-complexed AST described in the Western literature, all of which were adult (2-7) or teen-aged patients (8).…”