Another cause of ototoxicity: Clarithromycin

Whittemore, Kenneth R.; Dornan, Briana K.; Kenna, Margaret A.

doi:10.1016/j.pedex.2011.07.002

Cited by 5 publications

(3 citation statements)

References 8 publications

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“…Clarithromycin was discontinued, and 4 weeks later audiological testing had normalized. 26 In summary, the ototoxicity risk of clarithromycin was 9% (16/184) in healthy adults and 22% (6/27) among HIVpositive individuals based on the above papers.…”

Section: Discussionmentioning

confidence: 88%

“…[14][15][16] Evidence of HL associated with clarithromycin is limited to 3 small case series, 5 case reports, and 1 animal study, and studies investigating the persistence of HL due to clarithromycin have been contradictory. [17][18][19][20][21][22][23][24][25][26] Previous studies have included both adult and pediatric subjects, and none have focused specifically on children receiving prolonged clarithromycin treatment.…”

Section: Introductionmentioning

confidence: 99%

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Does Clarithromycin Cause Hearing Loss? A 12-Year Review of Clarithromycin Therapy for Nontuberculous Mycobacterial Lymphadenitis in Children

Heffernan

McKeon

Molony

et al. 2018

Ann Otol Rhinol Laryngol

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We noted a 7% hearing loss rate in our series. Confounding issues, such as 1 patient with a syndrome potentially contributing to HL, and limitations to this study, including retrospective design and loss to follow-up, temper our ability to conclude that clarithromycin was the sole cause of these HL. However, enough supporting data for a role in clarithromycin causing HL exist that testing should be considered for patients undergoing long-term clarithromycin treatment.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

Does Clarithromycin Cause Hearing Loss? A 12-Year Review of Clarithromycin Therapy for Nontuberculous Mycobacterial Lymphadenitis in Children

Heffernan

McKeon

Molony

et al. 2018

Ann Otol Rhinol Laryngol

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“…Distortion product OAEs were absent at 4 kHz, implicating abnormal outer hair cell function. Audiological testing was normal 4 weeks after clarithromycin was discontinued ( 67 ).…”

Section: Clarithromycin Ototoxicitymentioning

confidence: 99%

Ototoxicity of Non-aminoglycoside Antibiotics

2021

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It is well-known that aminoglycoside antibiotics can cause significant hearing loss and vestibular deficits that have been described in animal studies and in clinical reports. The purpose of this review is to summarize relevant preclinical and clinical publications that discuss the ototoxicity of non-aminoglycoside antibiotics. The major classes of antibiotics other than aminoglycosides that have been associated with hearing loss in animal studies and in patients are discussed in this report. These antibiotics include: capreomycin, a polypeptide antibiotic that has been used to treat patients with drug-resistant tuberculosis, particularly in developing nations; the macrolides, including erythromycin, azithromycin and clarithromycin; and vancomycin. These antibiotics have been associated with ototoxicity, particularly in neonates. It is critical to be aware of the ototoxic potential of these antibiotics since so much attention has been given to the ototoxicity of aminoglycoside antibiotics in the literature.

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