Another Case of Bell's Palsy Recurrence After Pfizer-BioNTech COVID-19 Vaccination

Zhang, Huailin; Gomez, Diana Sanchez; Repajic, Michael; Liu, Antonio K

doi:10.7759/cureus.27422

Cited by 4 publications

(3 citation statements)

References 8 publications

(9 reference statements)

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“…Researchers have proposed a potential link between recurrent Bell's and mRNA-based vaccines. 20 21 A retrospective cohort study indicated a strong association between mRNA COVID-19 vaccines and recurrent Bell’s palsy after a second vaccine dose. 22 …”

Section: Discussionmentioning

confidence: 99%

The Impact of the COVID-19 Pandemic on Bell’s Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study

Kwak,

Lee,

Lee

et al. 2024

J Korean Med Sci

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Background This article presents a comprehensive review of data on the impact of facial palsy during the coronavirus disease 2019 (COVID-19) pandemic. The possible causes and pathophysiological mechanisms of changes in the epidemiology of facial palsy during the COVID-19 pandemic are also discussed. Methods This multicenter retrospective cohort study included 943 patients diagnosed with Bell’s palsy or Ramsay Hunt syndrome. This study compared patient demographics, comorbidities, symptoms, and treatments before the COVID-19 pandemic (from 2017 to 2019) and during the COVID-19 pandemic, from 2020 to 2022). Results Following the COVID-19 outbreak, there has been a significant increase in the number of cases of Bell’s palsy, particularly among elderly individuals with diabetes. Bell’s palsy increased after the COVID-19 outbreak, rising from 75.3% in the pre-COVID-19 era to 83.6% after the COVID-19 outbreak. The complete recovery rate decreased from 88.2% to 73.9%, and the rate of recurrence increased from 2.9% to 7.5% in patients with Bell’s palsy. Ramsay Hunt syndrome showed fewer changes in clinical outcomes. Conclusion This study highlights the impact of the COVID-19 pandemic on the presentation and management of facial palsy, and suggests potential associations with COVID-19. Notably, the observed increase in Bell’s palsy cases among elderly individuals with diabetes emphasizes the impact of the pandemic. Identifying the epidemiological changes in facial palsy during the COVID-19 pandemic has important implications for assessing its etiology and pathological mechanisms of facial palsy disease.

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Section: Discussionmentioning

confidence: 99%

The Impact of the COVID-19 Pandemic on Bell’s Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study

Kwak,

Lee,

Lee

et al. 2024

J Korean Med Sci

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“…Another reported case involved a 56-year-old woman who suffered an intracerebral hemorrhage in the left temporal lobe extending into the intraventricular space immediately after receiving the Pfizer-BioNTech COVID-19 vaccine. 74 Despite surgical efforts to clip a ruptured aneurysm, the patient unfortunately passed away on the second postoperative day.…”

Section: Hemorrhagic Complicationsmentioning

confidence: 99%

Neurovascular Adverse Effects of Sars-Cov-2 Vaccination

Panos,

Bargiotas,

Hadjigeorgiou

et al. 2024

DDDT

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The global deployment of SARS-CoV-2 vaccines has been pivotal in curbing the COVID-19 pandemic, reducing morbidity and mortality associated with the virus. While most of these vaccines have demonstrated high efficacy and overall safety, emerging reports have highlighted potential neurovascular adverse effects, albeit uncommon, associated with these vaccinations. This review aims to assess and summarize the current knowledge on the neurovascular complications arising post-SARS-CoV-2 vaccination. We conducted an extensive literature review, focusing on clinical studies and case reports to identify reported neurovascular events, such as ischemic stroke, cerebral sinus venous thrombosis, intracerebral hemorrhage, pituitary apoplexy and primary CNS angiitis Despite the relative rarity of these events, their impact on affected individuals underscores the importance of ongoing surveillance, early detection, and management strategies. We aim to provide healthcare professionals with the latest evidence on neurovascular adverse effects, facilitating informed decision-making in the context of SARS-CoV-2 vaccination programs. Furthermore, we highlight areas requiring further research to understand the pathophysiology of these adverse events better and to develop targeted prevention and treatment strategies.

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“…Nineteen FNP cases were reported following COVID-19 vaccination [110][111][112][113][114][115][116][117][118][119][120][121][122][123][124][125][126] across the world. The patients' age ranged from 17 to 62 years (median (IQR): 38 (34, 57) years), 11 out of 19 patients were female (58%), and 4 patients had a prior history of FNP.…”

Section: Facial Nerve Palsymentioning

confidence: 99%

Neuromuscular diseases associated with COVID-19 vaccines: A systematic review and pooled analysis of 258 patients

Tayebi,

Samimisedeh,

Afshar

et al. 2023

Preprint

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Background: Neuromuscular diseases (NMD) emerged as one of the main side effects of the COVID-19 vaccination. We pooled and summarized the evidence on the clinical features and outcomes of NMD associated with COVID-19 vaccination. Methods: We comprehensively searched three databases, Medline, Embase, and Scopus, using the key terms covering “Neuromuscular disease” AND “COVID-19 vaccine”, and pooled the individual patient data extracted from the included studies. Results: A total of 258 NMD cases following COVID-19 have been reported globally; of which 171 cases were Guillain barre syndrome (GBS), 40 Parsonage-Turner syndrome (PTS), 22 Myasthenia Gravis (MG), 19 facial nerve palsy (FNP), 5 single fiber neuropathy, and 1 Tolosa-Hunt syndrome. All (100%) SFN patients and 58% of FNP patients were female; in remained NMDs, patients predominantly were male, including MG (82%), GBS (63%), and PTS (62.5%). The median time from vaccine to symptom was less than 2 weeks in all groups. Symptoms mainly appeared following the first dose of vector vaccine, but there was no certain pattern for mRNA-based. Conclusion: COVID-19 vaccines might induce some NMDs, mainly in adults. The age distribution and gender characteristics of affected patients may differ based on the NMD type. About two-thirds of the cases probably occur in less than two weeks from the vaccination.

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Another Case of Bell's Palsy Recurrence After Pfizer-BioNTech COVID-19 Vaccination

Cited by 4 publications

References 8 publications

The Impact of the COVID-19 Pandemic on Bell’s Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study

The Impact of the COVID-19 Pandemic on Bell’s Palsy and Ramsay-Hunt Syndrome: A Multicenter Retrospective Study

Neurovascular Adverse Effects of Sars-Cov-2 Vaccination

Neuromuscular diseases associated with COVID-19 vaccines: A systematic review and pooled analysis of 258 patients

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