Anosognosia for hemianaesthesia: A voxel-based lesion-symptom mapping study

Pia, Lorenzo; Spinazzola, Lucia; Garbarini, Francesca; Bellan, Giulia; Piedimonte, Alessandro; Fossataro, Carlotta; Livelli, A; Burin, Dalila; Berti, Anna

doi:10.1016/j.cortex.2014.08.006

Cited by 27 publications

(22 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This, in turn, weakens body ownership, which causes the hemiplegic hand to be more prone to the illusory effect. It is worth noting that in a previous study [ 42 ] on a spinal cord injury patient who still experienced the rubber hand illusion for the deafferented body parts, results were explained as a consequence of a pathological dominance of vision over proprioceptive/somatosensory information per se , rather than in terms of absence of movements (see also [ 46 , 47 ] for similar interpretations). Contrary to this study, our patients had a complete preserved proprioceptive and somatosensory functioning.…”

Section: Discussionmentioning

confidence: 83%

Are Movements Necessary for the Sense of Body Ownership? Evidence from the Rubber Hand Illusion in Pure Hemiplegic Patients

et al. 2015

Self Cite

View full text Add to dashboard Cite

A question still debated within cognitive neuroscience is whether signals present during actions significantly contribute to the emergence of human’s body ownership. In the present study, we aimed at answer this question by means of a neuropsychological approach. We administered the classical rubber hand illusion paradigm to a group of healthy participants and to a group of neurological patients affected by a complete left upper limb hemiplegia, but without any propriceptive/tactile deficits. The illusion strength was measured both subjectively (i.e., by a self-report questionnaire) and behaviorally (i.e., the location of one’s own hand is shifted towards the rubber hand). We aimed at examining whether, and to which extent, an enduring absence of movements related signals affects body ownership. Our results showed that patients displayed, respect to healthy participants, stronger illusory effects when the left (affected) hand was stimulated and no effects when the right (unaffected) hand was stimulated. In other words, hemiplegics had a weaker/more flexible sense of body ownership for the affected hand, but an enhanced/more rigid one for the healthy hand. Possible interpretations of such asymmetrical distribution of body ownership, as well as limits of our results, are discussed. Broadly speaking, our findings suggest that the alteration of the normal flow of signals present during movements impacts on human’s body ownership. This in turn, means that movements have a role per se in developing and maintaining a coherent body ownership.

show abstract

Section: Discussionmentioning

confidence: 83%

Are Movements Necessary for the Sense of Body Ownership? Evidence from the Rubber Hand Illusion in Pure Hemiplegic Patients

et al. 2015

Self Cite

View full text Add to dashboard Cite

show abstract

“…Months from onset: number of months between the onset of the disease and the first assessment. For visual field defect (the two values refer to the upper and lower visual quadrants, respectively), hemiplegia, anosognosia for hemiplegia and hemianesthesia scores were ranged from normal (0) to severe defects (3)48. General cognitive impairment (− = no deficit; + = presence of deficit): MOCA cut off ≥ 14.5/30; MMSE cut off ≥ 24/30.…”

Section: Figurementioning

confidence: 99%

Bodily ownership modulation in defensive responses: physiological evidence in brain-damaged patients with pathological embodiment of other’s body parts

Fossataro

Gindri

Mezzanato³

et al. 2016

Sci Rep

View full text Add to dashboard Cite

Do conscious beliefs about the body affect defensive mechanisms within the body? To answer this question we took advantage from a monothematic delusion of bodily ownership, in which brain-damaged patients misidentify alien limbs as their own. We investigated whether the delusional belief that an alien hand is their own hand modulates a subcortical defensive response, such as the hand-blink reflex. The blink, dramatically increases when the threated hand is inside the defensive peripersonal-space of the face. In our between-subjects design, including patients and controls, the threat was brought near the face either by the own hand or by another person’s hand. Our results show an ownership-dependent modulation of the defensive response. In controls, as well as in the patients’ intact-side, the response enhancement is significantly greater when the threat was brought near the face by the own than by the alien hand. Crucially, in the patients’ affected-side (where the pathological embodiment occurs), the alien (embodied) hand elicited a response enhancement comparable to that found when the threat is brought near the face by the real hand. These findings suggest the existence of a mutual interaction between our conscious beliefs about the body and the physiological mechanisms within the body.

show abstract

“…By means of a lesion subtraction technique on a larger sample of patients, a very recent study [15] attempted to obtain a clearer anatomo-functional picture of anosognosia for hemianesthesia. The authors compared two groups of patients differing only for the presence/absence of anosognosia for hemianesthesia and found that the lesion cluster specifically associated to anosognosia for hemianesthesia was confined to the anterior putamen (inters tingly, primary (and secondary somatosensory cortices were partially spared).…”

Section: Clinical Neuropsychological and Anatomo-functional Investigmentioning

confidence: 99%

Anosognosia for hemianesthesia: from the syndrome to tactile awareness

Pia¹,

Cavallo²,

Garbarini

2014

Translational Neuroscience

Self Cite

View full text Add to dashboard Cite

Patients with a neurologically based loss of tactile processing on the contralesional side of the body can firmly deny the deficit (i.e., anosognosia for hemianesthesia). Previous studies attempted to feature the disease in both clinical and anatomo-functional terms. However, the picture is still incomplete and, most importantly, to date it is unclear whether and to which extent it can shed light on the mechanisms subserving tactile processing in the intact brain. Here we will briefly review the literature and we will put forward a possible anatomo-functional interpretation of anosognosia for hemianesthesia.

show abstract

Anosognosia for hemianaesthesia: A voxel-based lesion-symptom mapping study

Cited by 27 publications

References 43 publications

Are Movements Necessary for the Sense of Body Ownership? Evidence from the Rubber Hand Illusion in Pure Hemiplegic Patients

Are Movements Necessary for the Sense of Body Ownership? Evidence from the Rubber Hand Illusion in Pure Hemiplegic Patients

Bodily ownership modulation in defensive responses: physiological evidence in brain-damaged patients with pathological embodiment of other’s body parts

Anosognosia for hemianesthesia: from the syndrome to tactile awareness

Contact Info

Product

Resources

About