Anosmia treatment by platelet rich plasma injection

Mavrogeni, Panayiota; Kanakopoulos, Angelos; Maihoub, Stefani; Maihoub, Samir; Krasznai, Magdolna; Szirmai, Ágnes

doi:10.5935/0946-5448.20160019

Cited by 20 publications

(37 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In our pilot study, only a single PRP injection was performed to first assess the safety and feasibility of this therapy. Mavrogeni and colleagues described four PRP injections with 4‐week intervals in between without any safety concerns . Taking this together with our findings from this study, future studies may benefit from multiple PRP treatments.…”

Section: Discussionsupporting

confidence: 65%

“…The role of PRP on olfactory neuroregeneration and related inflammation is unknown, but a preliminary animal study showed potential functional benefits of topical PRP in an anosmia induced mouse model . One pilot study evaluated PRP for hyposmia in humans and reported subjective improvements in five patients following treatment . However, that study lacked quantitative measurements of olfaction pre‐ and post‐treatment and other standardized norms.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study

Yan

Mundy

Patel

2020

Laryngoscope Investig Oto

View full text Add to dashboard Cite

Background: Olfactory dysfunction is a prevalent problem with a significant impact on quality of life and increased mortality. Limited effective therapies exist. Plateletrich plasma (PRP) is an autologous biologic product with anti-inflammatory and neuroprotective effects. This novel pilot study evaluated the role of PRP on olfactory neuroregeneration in patients with hyposmia.Methods: Seven patients who had olfactory loss greater than 6 months in duration, no evidence of sinonasal inflammatory disease, and no improvement with olfactory training and budesonide topical rinses were enrolled in this preliminary study.Patients received a single intranasal injection of PRP into the mucosa of the olfactory cleft. The Sniffin' Sticks olfactory test consisting of threshold, discrimination, and identification measurements (TDI) was administered at the beginning of the study and at 1 and 3 months.Results: All patients reported a subjective improvement of their smell shortly after injection but then stabilized. At 3-month post-treatment, two patients with functional anosmia (TDI < 16) did not improve significantly. Five patients with hyposmia (TDI > 16 but <30) showed an improvement with 60% achieving normosmia (TDI > 30) at 3-month follow-up. On average, patients with baseline TDI > 16 improved by 5.85 points with the most significant improvement in the threshold subcomponent. There were no adverse outcomes from intranasal PRP injections.Conclusion: PRP appears safe for use in the treatment of olfactory loss, and preliminary data suggest possible efficacy, especially for those with moderate yet persistent loss. Further studies will help determine optimal frequency and duration of use.

show abstract

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study

Yan

Mundy

Patel

2020

Laryngoscope Investig Oto

View full text Add to dashboard Cite

show abstract

“…Due to its advantages in wound healing, angiogenesis, use as glue material, post-operative pain and bleeding, PRP is also one of the interesting materials in otorhinolaryngology and head and neck surgery. A significant improvement in odor function was observed following platelet-rich plasma injection treatment applied in patients with anosmia [18].…”

mentioning

confidence: 94%

“…PRP was first used in 2016 by Mavrogeni et al [18], based on the view that platelets can accelerate the regeneration of the olfactory nerves in anosmia patients by secreting various growth factors and active metabolites, especially transforming growth factor. Following the application of PRP in the olfactory area of 5 patients with idiopathic anosmia in 4 sessions, the sense of smell returned in 4 patients and one patient stated that he could smell a little but could not smell all.…”

mentioning

confidence: 99%

“…Based on the view that it may accelerate the regeneration of olfactory nerves in anosmia patients due to its inclusion of growth factors, PRP was first used in 2016 by Mavrogeni et al [18] Following the application of PRP in the olfactory area of 5 patients with idiopathic anosmia in 4 sessions, the sense of smell returned in 4 patients, and one patient stated that he could smell a little but could not smell all. In a similar study conducted in 2020, although there was no significant improvement in Sniffin Sticks score in 2 patients with anosmia, it was observed that all 5 patients with hyposmia reached normosmia after 3 months of follow-up.…”

mentioning

confidence: 99%

See 1 more Smart Citation

The effectiveness of platelet rich plasma therapy in chronic sinusitis patients with odor disorder undergoing endoscopic sinus surgery

Kütük

Topuz²,

Guvey³

et al. 2022

The European Research Journal

View full text Add to dashboard Cite

Objectives: Objectives: In this study, the objective was to compare the effectiveness of fluticasone dipropionate and platelet-rich plasma treatments added to the treatment in patients undergoing functional endoscopic sinus surgery in patients with chronic sinusitis involving odor dysfunction, different stages and types of sinusitis. Methods: The study included a total of 60 patients between 18 and 60 years who underwent endoscopic sinus surgery due to chronic paranasal sinus infection followed by olfactory dysfunction. Group 1: paranasal sinus surgery + steroid therapy (first 30 patients) and Group 2: paranasal sinus surgery + steroid therapy + PRP therapy (second 30 patients) were grouped together without the patients' knowledge of the operating physician and of the treatment protocol. For the paranasal sinus CT evaluation, Lund-Mackey staging was used and the degree of the disease was determined using the Kennedy staging system. Modified Sniffin Stick test was applied to all patients in the preoperative 1 st week and in the 3 rd month postoperatively. The Modified Sniffin Stick test was conducted on all patients during the preoperative 1st week and the postoperative 3 rd month. The modified Sniffin Stick test and endoscopic evaluation score were evaluated and whether or not the patients benefited from PRP treatment were compared. Results: According to the postoperative endoscopy score, there was a difference between the experimental group and the control group in terms of postoperative endoscopy score, and it was found to be statistically significant. Besides, the postoperative endoscopy score of the experimental group was found to be lower than the control group. The average of Modified Sniffin' Stick Test scores in the postoperative period of the patients in the study was 28.27 ± 7.88 for the experimental group, while it was determined as 20.08 ± 5.75 for the control group, and this difference was statistically significant. The average anosmia times of the experimental and control group patients in the study were compared, and the mean duration of anosmia was 48. 53 ± 20.40 (6-96) for the experimental group and 44. 27 ± 19.45 (6.96) for the control group. The difference in the mean duration of anosmia between the experimental and control groups was not found statistically significant. Conclusions: In this research, PRP, which is applied to functional endoscopic sinus surgery and fluticasone dipropionate treatment, has been shown to be a readily applicable, safe and highly efficient method of treatment in patients with chronic sinusitis accompanied by smell dysfunction.

show abstract

International consensus statement on allergy and rhinology: Olfaction

Patel

Holbrook

Turner

et al. 2022

Int Forum Allergy Rhinol

View full text Add to dashboard Cite

Background:The literature regarding clinical olfaction, olfactory loss, and olfactory dysfunction has expanded rapidly over the past two decades, with an exponential rise in the past year. There is substantial variability in the quality of this literature and a need to consolidate and critically review the evidence. It is with that aim that we have gathered experts from around the world to produce this International Consensus on Allergy and Rhinology: Olfaction (ICAR:O). Methods: Using previously described methodology, specific topics were developed relating to olfaction. Each topic was assigned a literature review, evidence-based review, or evidence-based review with recommendations format as dictated by available evidence and scope within the ICAR:O document. Following iterative reviews of each topic, the ICAR:O document was integrated and reviewed by all authors for final consensus. Results:The ICAR:O document reviews nearly 100 separate topics within the realm of olfaction, including diagnosis, epidemiology, disease burden, diagnosis, testing, etiology, treatment, and associated pathologies. Conclusion:This critical review of the existing clinical olfaction literature provides much needed insight and clarity into the evaluation, diagnosis, and treatment of patients with olfactory dysfunction, while also clearly delineating gaps in our knowledge and evidence base that we should investigate further.

show abstract

Anosmia treatment by platelet rich plasma injection

Abstract: Based on our results, platelet rich plasma administration to the olfactory region could be a promising, last chance therapy for complete anosmia.

Cited by 20 publications

References 11 publications

The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study

The use of platelet‐rich plasma in treatment of olfactory dysfunction: A pilot study

The effectiveness of platelet rich plasma therapy in chronic sinusitis patients with odor disorder undergoing endoscopic sinus surgery

International consensus statement on allergy and rhinology: Olfaction

Contact Info

Product

Resources

About