Anorexic and metabolic effect of jojoba: potential treatment against metabolic syndrome and hepatic complications

Abstract

Background: Evaluation of the action of various traditional plants to treat metabolic syndrome are strongly studied. In our study, we investigated the effect of the Tunisian jojoba seed on a metabolic syndrome induced in rat by the High Fat diet and High Fructose (HFHF) and its renal and hepatic complications. Methods: The rats were fed with HFHF or Normal Diet (ND) for a period of 8 weeks. After that, a switch from HFHF to ND or Normal Diet Jojoba (NDJ),(jojoba diet approach) or High Fat and High Fructose and Jojoba diet (HFHFJ) (nutraceutical approach) has been done. Metabolic disorder was evaluated by measuring the fasting body weight, glycemia and C-peptide and leptin. Oxidative stress parameters like ThioBarbituric Acid Reactive Substances (TBARS) and Total Antioxidant Capacity (TAOC) were analyzed in the plasma and renal and hepatic function were determined by the measure of creatinine and alanine transferase (ALT) respectively. Histological analysis was performed on the liver, kidney and pancreas. Results: HFHF diet exhibited characteristics of metabolic syndrome presented by insulin resistance, hyperinsulinemia, hyperleptinemia, fat mass with hepatic steatosis and renal disorder. HFHF diet was associated with oxidative stress (OS) presented by an increase in TBARS and a decrease in TAOC. Adding jojoba seeds to HFHF rat group diet induced a decrease in body weight, fat mass (58 and 41%), insulin resistance (59 and 56%), oxidative stress (60 and 41%), liver steatosis (from a score = 3 to a score = 0) and renal complications (25 and 42%). This effect was emphasized with diet approach. Conclusion: The results demonstrated the beneficial effect of jojoba against metabolic syndrome and oxidative stress, suggesting that jojoba could be used in the prevention and treatment of metabolic syndrome.

Jojoba Seed Oil as Feed Additive for Sustainable Broiler Meat Production under Hot Climatic Conditions

“…The improved FCR can result in increased growth performance and meat quality of broilers raised under hot climatic condition. Jojoba oil has antimicrobial and antioxidant activities [18,26] that may support improvements in broiler performance in this study. Supplementation of Hippophae rhamnoides extract as a phytogenic feed additive in broiler diets increased growth performance in chickens, leading to a subsequent improved economic return [12].…”

“…Concerning the carcass criteria in the current study, jojoba seed oil improved dressing percentage and decreased abdominal fat percentage at 35 days of age, which could be due to the biologically active chemical components of jojoba seed oil (Table 2). The decrease in abdominal fat is mainly due to PLBC in broilers' diet improving activities of amylase and trypsin [31,32] and secretion of bile acids [18,26,33,34]. Unfortunately, no literature is available on the effect of jojoba seed oil on the carcass criteria of broilers; therefore, the comparisons were performed with other phytogenics.…”

Jojoba Oil: An Updated Comprehensive Review on Chemistry, Pharmaceutical Uses, and Toxicity

“…Similar results were confirmed in a recent study that indicated jojoba seeds induced a decrease in body weight, fat mass, insulin resistance, oxidative stress, liver steatosis and renal complications. The results demonstrated the beneficial effect of jojoba against metabolic syndrome and oxidative stress [ 48 ].…”

Development of rat metabolic syndrome models: A review

“…The increase in triglycerides mainly occurs due to high-fructose diets, whereas obesity occurs due to high-fat diets. This combination diet was associated with an increase in plasma cholesterol levels, a decrease in HDL cholesterol, and a 2-fold increase in liver weight in rats (Table-5) [39][40][41][42][43][44][45]. A study has shown the accumulation of lipids in the myocardium, left ventricular hypertrophy, and morphological liver damage.…”