Anorexia nervosa and juvenile lupus erythematosus in a 16-year-old female patient – common disease origin or random coincidence?

Hyla-Klekot, Lidia; Wolny, Agnieszka; Janas–Kozik, Małgorzata; Koszutski, Tomasz

doi:10.5114/ceji.2021.104326

Cited by 7 publications

(15 citation statements)

References 21 publications

(14 reference statements)

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“…A total of three case reports [ 51 , 52 , 53 ] and one case series [ 54 ] were retrieved from the scientific literature. Table 1 describes the available scientific literature presenting case reports of pediatric patients with SLE and AN.…”

Section: Resultsmentioning

confidence: 99%

“…Hyla-Klekot [ 51 ] ( Table 1 ) presented a 16-year old girl exhibiting severe AN and a strict refusal to consume food, who subsequently exhibited symptoms of Raynaud’s phenomena and developed lupus, although the severity of AN manifestations induced a significant delay in the SLE diagnosis. Again, SLE activity and symptoms of AN were resolved following aggressive immunosuppressive therapy.…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, AN and SLE appear to be characterized by the presence of specific brain-reactive autoantibodies, which are responsible for the development of NP disorders among those with SLE, as well as being responsible for the development of SLE in patients with mental disorders [ 46 ]. Given the increased production of autoantibodies observed in patients with SLE, it is highly possible that some antibodies may also act against specific neurotransmitters, participating in food and appetite regulation [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

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Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma

et al. 2023

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Juvenile-onset systemic lupus erythematosus (jSLE) is an autoimmune disorder with multifaceted clinical findings in different organ systems. Neuropsychiatric manifestations affect more than half of SLE patients, and there is increasing evidence that anorexia nervosa (AN), a feeding and eating disorder (FED) characterized by significantly reduced energy intake, is among them. Herein, a review of the literature on the potential association between jSLE and AN was performed. Reported clinical cases were identified, and putative pathophysiological mechanisms were sought that could potentially explain the observed relationship between these two pathological entities. Four reports of isolated cases and a case series including seven patients were identified. In this limited patient pool, the diagnosis of AN preceded that of SLE in the majority of cases, whereas in all cases both entities were diagnosed within a time span of two years. Many explanations for the observed relationships have been proposed. AN has been associated with the stress of chronic disease diagnosis; on the other hand, the chronic inflammation associated with AN may contribute to the development/appearance of SLE. Adverse childhood experiences, concentrations of leptin, shared autoantibodies, and genetic traits appear to be important factors in this well-established interplay. In essence, it seems important to increase clinician awareness of the concomitant development of AN and SLE and invite further research on the subject.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma

et al. 2023

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“…The coexistence of AN and SLE is reported in rare cases [2,13] . Juvenile SLE and AN were reported in three cases and one case series [2,[19][20][21] ; meanwhile, Sloan et al [21] published a case of an adolescent with SLE and AN.…”

Section: Discussionmentioning

confidence: 99%

Anorexia nervosa and systemic lupus erythematosus: a coincidence?

Kudsi,

Tarcha,

Khalayli

et al. 2024

International Journal of Surgery: Global Health

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Introduction and importance: The COVID-19 pandemic has led to a post-acute syndrome that can persist for an extended period. The correlation between anorexia nervosa (AN) and some autoimmune diseases has been reported. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease, presented with different clinical ions and periods, affecting all ages, especially females. The coexistence of SLE and AN has been reported in rare cases. The authors present the case of a 22-year-old male with severe AN coexisting with SLE. Case presentation: We present a case of a 22-year-old male diagnosed with SLE. He also completely refused to eat and drink and presented with behavioral disorders and suicidal thoughts. He was on 200 mg/day of oral hydroxychloroquine, 400 units/day of vitamin D, and 1000 mg/day of oral calcium. There was no positive other history, trauma, drug addiction, or family history. AN was diagnosed according to ICD-10 and DSM-V. Physical examination revealed decreased subcutaneous tissue and muscle atrophy. The weight of the patient was 35.3 kg. Verbal contact was maintained, and psychotic symptoms were not observed. Tenderness in all joints was noticed, while swelling in both knees and right ankle joints was found. Laboratory tests revealed elevated inflammatory markers. Treatment includes a high-calorie diet administered by a feeding tube. The patient began to gain weight after 3 months. He is on 200 mg/day hydroxychloroquine, with remission till now January 2024. Clinical discussion: The novelty of our case is that it is a case of a young adult man presented with AN during mild lupus, who responded well to treatment with steroids and a high-calorie diet. Conclusions: Previous research has suggested the existence of a close link between food and eating disturbance and autoimmunity, and herein we provide further evidence to support this relationship by presenting a case report of an adult male with SLE and AN.

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“…The association between various autoimmune diseases and anorexia is described (Table 1 ). Hyla‐Klekot et al 57 described a case of associated anorexia and juvenile systemic lupus erythematosus. Like other authors before them, they suggest a common origin of the two diseases on the basis of their coexistence and the resolution of anorexia as a consequence of the immunosuppressive treatment.…”

Section: The Shared Immunological Pathways Of Autoimmune and Eating D...mentioning

confidence: 99%

Anorexia nervosa and autoimmune comorbidities: A bidirectional route?

et al. 2022

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Immunological dysfunctions in eating disorders have recently gained increasing scientific attention. Furthermore, the reciprocal association between anorexia and autoimmune diseases is of particular interest and suggests a role of autoimmunity in the pathogenesis of eating disorders. Anorexia nervosa (AN) and autoimmune diseases are linked by a bidirectional relationship based on common immunopathological mechanisms. In this review, in addition to reporting the numerous cases described in which autoimmune disorders are associated with anorexia or vice versa, we summarize the many aspects of this relationship between the immune system (IS) and AN. We describe how the microbiota affects the IS, disrupts gut‐brain communication, and possibly triggers eating disorders. We also describe the shared immunological pathways of autoimmune and eating disorders and in particular the occurrence of disrupted T cell tolerance and autoantibodies in AN. The described observations represent the starting point for possible, future research directions.

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Anorexia nervosa and juvenile lupus erythematosus in a 16-year-old female patient – common disease origin or random coincidence?

Cited by 7 publications

References 21 publications

Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma

Anorexia Nervosa in Juvenile Systemic Lupus Erythematosus (SLE): A Causality Dilemma

Anorexia nervosa and systemic lupus erythematosus: a coincidence?

Anorexia nervosa and autoimmune comorbidities: A bidirectional route?

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