Anorexia Nervosa: Analysis of Trabecular Texture with CT

Tabari, Azadeh; Torriani, Martin; Miller, Karen K.; Klibanski, Anne; Kalra, Mannudeep K.; Bredella, Miriam A.

doi:10.1148/radiol.2016160970

Cited by 18 publications

(11 citation statements)

References 42 publications

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“…Because traditional visual inspection of images might not allow for recognizing subtle differences in textural information, the application of TA has the potential to further enhance the diagnostic and prognostic value of imaging. The increase of interest in evaluating TA in radiology is reflected by recent literature describing potential applications of the technique in oncologic (11)(12)(13), neuroradiologic (14), musculoskeletal (15,16), and lung imaging (17). To our knowledge, only one preliminary study, published as a conference abstract, has evaluated the potential of TA for cardiac MR imaging so far (18).…”

Section: Cardiac Mr Imaging Data Acquisitionmentioning

confidence: 99%

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Subacute and Chronic Left Ventricular Myocardial Scar: Accuracy of Texture Analysis on Nonenhanced Cine MR Images

et al. 2018

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Purpose To test whether texture analysis (TA) allows for the diagnosis of subacute and chronic myocardial infarction (MI) on noncontrast material-enhanced cine cardiac magnetic resonance (MR) images. Materials and Methods In this retrospective, institutional review board-approved study, 120 patients who underwent cardiac MR imaging and showed large transmural (volume of enhancement on late gadolinium enhancement [LGE] images >20%, n = 72) or small (enhanced volume 20%, n = 48) subacute or chronic ischemic scars were included. Sixty patients with normal cardiac MR imaging findings served as control subjects. Regions of interest for TA encompassing the left ventricle were drawn by two blinded, independent readers on cine images in end systole by using a freely available software package.Stepwise dimension reduction and texture feature selection based on reproducibility, machine learning, and correlation analyses were performed for selecting features, enabling the diagnosis of MI on nonenhanced cine MR images by using LGE imaging as the standard of reference. Results Five independent texture features allowed for differentiation between ischemic scar and normal myocardium on cine MR images in both subgroups: Teta1, Perc.01, Variance, WavEnHH.s-3, and S(5,5)SumEntrp (in patients with large MI: all P values < .001; in patients with small MI: Teta1 and Perc.01, P < .001; Variance, P = .026; WavEnHH.s-3, P = .007; S[5,5]SumEntrp, P = .045). Multiple logistic regression models revealed that combining the features Teta1 and Perc.01 resulted in the highest accuracy for diagnosing large and small MI on cine MR images, with an area under the curve of 0.93 and 0.92, respectively. Conclusion This proof-of-concept study indicates that TA of nonenhanced cine MR images allows for the diagnosis of subacute and chronic MI with high accuracy. (©) RSNA, 2017 Online supplemental material is available for this article. Purpose:To test whether texture analysis (TA) allows for the diagnosis of subacute and chronic myocardial infarction (MI) on noncontrast material-enhanced cine cardiac magnetic resonance (MR) images. Materials and Methods:In this retrospective, institutional review board-approved study, 120 patients who underwent cardiac MR imaging and showed large transmural (volume of enhancement on late gadolinium enhancement [LGE] images .20%, n = 72) or small (enhanced volume 20%, n = 48) subacute or chronic ischemic scars were included. Sixty patients with normal cardiac MR imaging findings served as control subjects. Regions of interest for TA encompassing the left ventricle were drawn by two blinded, independent readers on cine images in end systole by using a freely available software package. Stepwise dimension reduction and texture feature selection based on reproducibility, machine learning, and correlation analyses were performed for selecting features, enabling the diagnosis of MI on nonenhanced cine MR images by using LGE imaging as the standard of reference. Results:Five independent texture features allowed ...

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Section: Cardiac Mr Imaging Data Acquisitionmentioning

confidence: 99%

“…We included 120 patients (15 (2), highlighting the relevance of detecting and characterizing myocardial scar to guide intensive secondary prevention (3).…”

Section: Study Populationmentioning

confidence: 99%

Subacute and Chronic Left Ventricular Myocardial Scar: Accuracy of Texture Analysis on Nonenhanced Cine MR Images

et al. 2018

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“…Kurtosis is a feature derived from the histogram matrix and reflects how values in the histogram are distributed. The higher the kurtosis, the more peaked and uniform is the distribution of pixel gray-levels in the image; the lower the kurtosis, the more heterogeneous the pixel gray-level distribution becomes, being represented by a flatter and broader histogram curve as compared with the normal distribution (26). Thus, the lower T2_ kurtosis in EMB-positive chronic heart failure-like myocarditis (P , .001) reflects a broader and more inhomogeneous pixel gray-level distribution in the corresponding T2 maps.…”

Section: Mri Texture Analysis In Chronic Heart Failure-like Myocarditismentioning

confidence: 99%

Cardiac MRI and Texture Analysis of Myocardial T1 and T2 Maps in Myocarditis with Acute versus Chronic Symptoms of Heart Failure

Baeßler¹,

Luecke²,

Lurz³

et al. 2019

Radiology

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yocarditis is the leading cause of heart failure in individuals under 40 years of age (1). It frequently leads to dilated cardiomyopathy (2) and represents one of the most challenging diagnoses in clinical cardiology. Growing clinical evidence exists that myocarditis is a multifaceted disease, where different subtypes can be differentiated based on the predominant clinical presentation (3). Consequently, the diagnostic approach for myocarditis manifesting with symptoms of heart failure (heart failure-like myocarditis) should be different from myocarditis with acute infarctlike presentation (3-6). Establishing the timely and correct diagnosis, especially in individuals with heart failure-like myocarditis, is of importance because these individuals might benefit from a tailored therapeutic strategy. However, the primary tools for noninvasive diagnosis of myocarditis, including cardiac MRI and diagnostic requirements as defined by the Lake Louise criteria, have been shown to exhibit a very limited diagnostic accuracy in heart failurelike and chronic myocarditis (3-7). Recently, T1 and T2 mapping techniques have been introduced as quantitative approaches for a more reliable

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“…Both measures were associated positively with BMI and inversely with the duration of amenorrhea. Another study assessed vertebral bone texture using a low-dose single-section quantitative CT of the L4 vertebral body with use of a calibration phantom, and reported altered bone texture in women with AN, which was associated with lowest lifetime body weight and duration of amenorrhea [31]. …”

Section: Assessment Of Bone Outcomes Including Use Of Novel Techniquesmentioning

confidence: 99%

Eating disorders and bone metabolism in women

Robinson

Micali

Misra

2017

Current Opinion in Pediatrics

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Purpose of this Review Eating Disorders are psychiatric disorders associated with high risk for low bone mineral density (BMD) and fractures. Low BMD is likely to be a consequence of undernutrition, changes in body composition, and hormonal alterations. This review summarizes recent findings regarding: novel strategies for assessing bone outcomes in patients with eating disorders, factors contributing to altered bone metabolism, and possible therapeutic strategies. Recent Findings Emerging research in this field suggests that not only anorexia nervosa (AN), but also bulimia nervosa (BN) results in lower BMD compared to controls. To date studies of bone structure, and all randomized controlled trials (RCTs) examining the impact of various therapies on bone outcomes in AN, have focused on adolescent girls and women. We discuss the impact of AN on bone structure, and associations of resting energy expenditure, marrow adipose tissue (including the ratio of saturated to unsaturated fat), and cold activated brown adipose tissue (BAT) with BMD and bone structure. Promising strategies for treatment include physiological estrogen replacement (rather than oral contraceptives), in adolescent girls with AN, and bisphosphonates, as well as teriparatide, in adult women with AN. Summary Recent data on: (i) BMD and bone structure in adolescent girls and women with eating disorders, (ii) factors that contribute to altered bone metabolism, and (iii) RCTs reporting positive effects of physiologic estrogen replacement, bisphosphonates and teriparatide on bone health provide us with a greater understanding of the impact of eating disorders on bone and novel management strategies.

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Anorexia Nervosa: Analysis of Trabecular Texture with CT

Cited by 18 publications

References 42 publications

Subacute and Chronic Left Ventricular Myocardial Scar: Accuracy of Texture Analysis on Nonenhanced Cine MR Images

Subacute and Chronic Left Ventricular Myocardial Scar: Accuracy of Texture Analysis on Nonenhanced Cine MR Images

Cardiac MRI and Texture Analysis of Myocardial T1 and T2 Maps in Myocarditis with Acute versus Chronic Symptoms of Heart Failure

Eating disorders and bone metabolism in women

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