Anorectal melanoma in The Netherlands: a report of 63 patients

Roumen, R.M.H.

doi:10.1016/s0748-7983(96)92346-x

Cited by 118 publications

(83 citation statements)

References 7 publications

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“…It should be noted, however, that in most studies it is difficult to compare patient's prognostic factors due to the fact that insufficient information is provided. Nevertheless, there was a trend that local disease is more effectively controlled by APR than WLE (Abbas et al, 1980;Ross et al, 1990;Roumen, 1996;Thibault et al, 1997). To this end, Thibault reported that isolated local recurrences after APR were rare (Thibault et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…However, this study is flawed by several inconsistencies such as missing progress reports or the fact that none of the locally treated tumours were below 4 mm in tumour thickness. Roumen (1996) reported a series of 34 patients, 18 of them were treated by APR whereas 16 patients received WLE. Interestingly, only one of the patients treated by APR developed a local recurrence.…”

Section: Discussionmentioning

confidence: 99%

“…It accounts only for approximately 0.5% of all colorectal and anal cancers (Roumen, 1996). Nevertheless, the anorectum is the most common site for development of primary melanoma in the alimentary tract.…”

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confidence: 99%

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Anorectal melanoma: surgical management guidelines according to tumour thickness

et al. 2003

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Management of patients with anorectal melanoma is still controversial. To reach a rationale therapeutic approach, we reviewed our experience obtained over the past decade. In all, 19 consecutive patients with the diagnosis of anorectal melanoma were included in this retrospective survey. Details of the patients' presentation, symptoms, tumour size and histology and tumour state were recorded, and the primary therapeutic procedures were evaluated in detail. The size of the tumours ranged between 0.5 and 7 cm in diameter. The median tumour thickness was 10 mm (range 0.6 -40 mm). At diagnosis, six of 19 patients already presented with either regional or distant metastases. The remaining 13 patients were treated with curative intend, either by abdomino-perineal resection (APR) or wide local excision (WLE). The form of operative therapy, however, had no impact on overall survival. Nevertheless, the incidence of local recurrences was lower after APR even for patients with less favourable tumours. In conclusion, WLE alone is not sufficient for local tumour control of thick anorectal melanoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Anorectal melanoma: surgical management guidelines according to tumour thickness

et al. 2003

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“…The reported 5-year overall survival rate is 6%-15% of patients after surgery. 3,[6][7][8][9][10][11] Early-stage detection is important. The main determinants of prognosis are the depth of invasion and stage of the disease.…”

Section: Discussionmentioning

confidence: 99%

Primary anal malignant melanoma: a case report

et al. 2015

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“…Anorectal melanoma is rare and accounts for 0.4%-1.6% of all melanoma cases [101] (Figure 4). In one large series, anorectal melanomas represented 0.5% of all colorectal and anal cancers [102]. Similar to melanomas of the female genital tract because of the contiguity of the mucosal and cutaneous tissues, it is important to define the exact anatomic location of anal melanomas because many of them may actually be cutaneous in origin.…”

Section: Case Vignettementioning

confidence: 99%

Mucosal Melanomas: A Case-Based Review of the Literature

2010

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After completing this course, the reader will be able to:1. Differentiate mucosal melanoma from cutaneous melanoma and describe its etiology, molecular features, and treatment approaches in surgical, radiation, and medical oncology.2. Evaluate mucosal melanoma patients with non-metastatic disease for adjuvant radiation to optimize treatment of the primary tumor.3. Refer appropriate patients for testing for c-KIT mutations and gene aberrations in order to avoid subjecting them to chemotherapy with minimal benefit.This article is available for continuing medical education credit at CME.TheOncologist.com. CME CME ABSTRACTMucosal melanoma is a rare cancer that is clearly distinct from its cutaneous counterpart in biology, clinical course, and prognosis. Recent studies have shown important differences in the frequencies of various genetic alterations in different subtypes of melanoma. Activating mutations in the c-KIT gene are detected in a significant number of patients with mucosal melanoma. This observation has resulted in the initiation of several clinical trials aimed at exploring the role of receptor tyrosine kinases that inhibit c-KIT in this patient population. We herein present a comprehensive literature review of mucosal melanoma along with case vignettes of a number of pertinent cases. We further discuss melanomas of the head and neck, the female genital tract, and the anorectum, which are the three most common sites of mucosal melanoma, with a particular focus on the diagnostic, prognostic, and therapeutic data available in the literature. The Oncologist 2010;15:772-781

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Anorectal melanoma in The Netherlands: a report of 63 patients

Cited by 118 publications

References 7 publications

Anorectal melanoma: surgical management guidelines according to tumour thickness

Anorectal melanoma: surgical management guidelines according to tumour thickness

Primary anal malignant melanoma: a case report

Mucosal Melanomas: A Case-Based Review of the Literature

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