Anophthalmia in Litters of Female Rats Treated with the Food-Derived Carcinogen, 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine

Ikeda, Yoshihisa; Takahashi, Satoru; Kimura, Juki; Cho, Young‐Man; Imaida, Katsumi; Shirai, Shoichiro; Shirai, Tomoyuki

doi:10.1177/019262339902700603

Cited by 5 publications

(2 citation statements)

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“…More important in terms of evolution, it may also negatively affect fertility both in women [ 13 , 35 ] and in men [ 8 , 12 , 36 ], and lead to an increase in pregnancy complications [ 5 , 6 , 37 ]. For genotoxic food heating products similar effects are to be expected and, consistent with this expectation, placental transfer of heterocyclic amines to the foetus [ 38 ], reduced offspring and severe teratogenic effects have been reported [ 39 ]. Significant longevity, and thus diseases of aging such as cancer, may have come late in human evolution, probably only with modern humans [ 40 ].…”

Section: Introductionsupporting

confidence: 57%

Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans

et al. 2016

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Studies of the defence capacity of ancient hominins against toxic substances may contribute importantly to the reconstruction of their niche, including their diets and use of fire. Fire usage implies frequent exposure to hazardous compounds from smoke and heated food, known to affect general health and fertility, probably resulting in genetic selection for improved detoxification. To investigate whether such genetic selection occurred, we investigated the alleles in Neanderthals, Denisovans and modern humans at gene polymorphisms well-known to be relevant from modern human epidemiological studies of habitual tobacco smoke exposure and mechanistic evidence. We compared these with the alleles in chimpanzees and gorillas. Neanderthal and Denisovan hominins predominantly possess gene variants conferring increased resistance to these toxic compounds. Surprisingly, we observed the same in chimpanzees and gorillas, implying that less efficient variants are derived and mainly evolved in modern humans. Less efficient variants are observable from the first early Upper Palaeolithic hunter-gatherers onwards. While not clarifying the deep history of fire use, our results highlight the long-term stability of the genes under consideration despite major changes in the hominin dietary niche. Specifically for detoxification gene variants characterised as deleterious by epidemiological studies, our results confirm the predominantly recent appearance reported for deleterious human gene variants, suggesting substantial impact of recent human population history, including pre-Holocene expansions.

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Section: Introductionsupporting

confidence: 57%

Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans

et al. 2016

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“…Exposure to endocrine disrupting chemicals: Ema et al (1999aEma et al ( , 1999bEma et al ( , 2000, Hirose et al (1999), Ikeda et al (1999), Nagao et al (1999aNagao et al ( , 1999bNagao et al ( , 2000aNagao et al ( , 2000b, Ohta et al (2000), Shirai et al (1999), Tamura et al (1999).…”

Section: Research Projectsmentioning

confidence: 99%

Endocrine disruptors and environmental impact in Japan

Nakata

2002

Cad. Saúde Pública

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Teixeira

Dubielzig

2013

Haschek and Rousseaux's Handbook of Toxicologic Pathology

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Anophthalmia in Litters of Female Rats Treated with the Food-Derived Carcinogen, 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine

Abstract: Anophthalmia in litters of pregnant rats treated with 2-amino-1-methyl-6-phenylimidazo [4,5-b]

Cited by 5 publications

References 24 publications

Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans

Fire Usage and Ancient Hominin Detoxification Genes: Protective Ancestral Variants Dominate While Additional Derived Risk Variants Appear in Modern Humans

Endocrine disruptors and environmental impact in Japan

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