Anopheles darlingi (Diptera: Culicidae) displays increased attractiveness to infected individuals with Plasmodium vivax gametocytes

Batista, Elis P. A.; Costa, Elizangela Fm; Silva, Alexandre de Almeida e

doi:10.1186/1756-3305-7-251

Cited by 57 publications

(51 citation statements)

References 12 publications

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“…This facilitates the Plasmodium spp. transmission to the mosquito, its definitive host (Cornet et al, 2013;Batista et al, 2014). Until very recently the mechanism for this behavioral manipulation was unknown.…”

Section: Challenges In Assessing Neurochemical Behavioral Manipulationmentioning

confidence: 99%

Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation

Herbison

2017

Front. Ecol. Evol.

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Scientific and public interest in host manipulation by parasites has surged over the past few decades, resulting in an exponential growth of cases where potential behavioral manipulation has been identified. However, these studies dwarf the number of genuine attempts to elucidate the mechanistic processes behind this behavioral manipulation. Ultimately, this imbalance has slowed progress in the study of the mechanisms underlying host manipulation. As it stands, research suggests that the mechanisms of host manipulation fall into three categories: immunological, genomic/proteomic and neuropharmacological, and forth potential category: symbioant-mediated manipulation. After exploration of the literature pertaining to these four pathways, four major trends become evident. First and foremost, there is a severe disconnect between the observed molecular and behavioral shifts in a parasitized host. Indeed, very rarely a study demonstrates that molecular changes observed in a host are the result of active manipulation by the resident parasite, or that these molecular changes directly result in behavioral manipulation that increases the parasite's fitness. Secondly, parasites may often employ multiple pathways in unison to achieve control over their hosts. Despite this, current scientific approaches usually focus on each manipulation pathway in isolation rather than integrating them. Thirdly, the relative amount of host-parasite systems yet to be investigated in terms of molecular manipulation is staggering. Finally, as a result of the aforementioned trends, guiding mechanisms or principles for the multiple types of behavioral manipulation are yet to be found. Researchers should look to identify the manipulative factors required to generate the molecular changes seen in hosts, while also considering the "multi-pronged" approach parasites are taking to manipulate behavior. Assessing gene expression and its products during transitional periods in parasites may be a key methodological approach for tackling these recent trends in the host manipulation literature.

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Section: Challenges In Assessing Neurochemical Behavioral Manipulationmentioning

confidence: 99%

Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation

Herbison

2017

Front. Ecol. Evol.

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“…(Rossignol et al, 1985); 'Is it more attractive to mosquitoes?' (Batista et al, 2014); 'Is the sporozoite-infected mosquito more likely to probe?' (Anderson et al, 1999).…”

Section: From Vertebrate Host To Insect Vectormentioning

confidence: 99%

“…The impact of gametocytes on the biology of host/parasite–vector interactions has for decades provoked intriguing discussion and experimentation. ‘Is the infectious host less responsive to mosquito bites?’ (Rossignol et al ., ); ‘Is it more attractive to mosquitoes?’ (Batista et al ., ); ‘Is the sporozoite‐infected mosquito more likely to probe?’ (Anderson et al ., ). At the cellular level the oft‐raised question whether mature (infectious) gametocytes are preferentially retained in the capillaries of the skin where they would be accessible to the mosquito remains an interesting but still unresolved question.…”

Section: Introductionmentioning

confidence: 99%

The cell biology of malaria infection of mosquito: advances and opportunities

Sinden

2015

Cell Microbiol

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Recent reviews (Feachem et al.; Alonso et al.) have concluded that in order to have a sustainable impact on the global burden of malaria, it is essential that we knowingly reduce the global incidence of infected persons. To achieve this we must reduce the basic reproductive rate of the parasites to < 1 in diverse epidemiological settings. This can be achieved by impacting combinations of the following parameters: the number of mosquitoes relative to the number of persons, the mosquito/human biting rate, the proportion of mosquitoes carrying infectious sporozoites, the daily survival rate of the infectious mosquito and the ability of malaria-infected persons to infect mosquito vectors.This paper focuses on our understanding of parasite biology underpinning the last of these terms: infection of the mosquito. The article attempts to highlight central issues that require further study to assist in the discovery of useful transmission-blocking measures.

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“…This hypothesis proposes that pathogens manipulate a host's phenotype to increase host-vector contact rates, thereby enhancing both the probability of pathogen acquisition and the transmission to a new host (Lefèvre et al, 2006;Lefèvre and Thomas, 2008;Mauck et al, 2010Mauck et al, , 2012. Indeed, the enhanced attractiveness of infected hosts to vectors has been reported in plants (Eigenbrode et al, 2002;Shapiro et al, 2012), invertebrates (Stafford et al, 2011) and vertebrates (O'Shea et al, 2002;Cornet et al, 2013 a, b;De Moraes et al, 2014) including humans (Lacroix et al, 2005;Batista et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Avian malaria infection intensity influences mosquito feeding patterns

Yan

Puente

Gangoso

et al. 2018

International Journal for Parasitology

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Pathogen-induced host phenotypic changes are widespread phenomena that can dramatically influence host-vector interactions. Enhanced vector attraction to infected hosts has been reported in a variety of host-pathogen systems, and has given rise to the parasite manipulation hypothesis whereby pathogens may adaptively modify host phenotypes to increase transmission from host to host. However, host phenotypic changes do not always favour the transmission of pathogens, as random host choice, reduced host attractiveness and even host avoidance after infection have also been reported. Thus, the effects of hosts' parasitic infections on vector feeding behaviour and on the likelihood of parasite transmission remain unclear. Here, we experimentally tested how host infection status and infection intensity with avian Plasmodium affect mosquito feeding patterns in house sparrows (Passer domesticus). In separate experiments, mosquitoes were allowed to bite pairs containing (i) one infected and one uninfected bird and (ii) two infected birds, one of which treated with the antimalarial drug, primaquine. We found that mosquitoes fed randomly when exposed to both infected and uninfected birds. However, when mosquitoes were exposed only to infected individuals, they preferred to bite the non-treated birds. These results suggest that the malarial parasite load rather than the infection itself plays a key role in mosquito attraction. Our findings partially support the parasite manipulation hypothesis, which probably operates via a reduction in defensive behaviour, and highlights the importance of considering parasite load in studies on host-vector-pathogen interactions.

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Anopheles darlingi (Diptera: Culicidae) displays increased attractiveness to infected individuals with Plasmodium vivax gametocytes

Cited by 57 publications

References 12 publications

Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation

Lessons in Mind Control: Trends in Research on the Molecular Mechanisms behind Parasite-Host Behavioral Manipulation

The cell biology of malaria infection of mosquito: advances and opportunities

Avian malaria infection intensity influences mosquito feeding patterns

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