Anomolies between radiological and chemical limits for uranium after inhalation by workers and the public

Stradling, N.; Hodgson, Alan; Ansoborlo, É.; Bérard, P.; Etherington, G.; Fell, Timothy; LeGuen, B.

doi:10.1093/oxfordjournals.rpd.a006218

Cited by 8 publications

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“…The effects of EHBP have been determined (Ubios et al 1994;Hengé-Napoli et al 1999;Martinez et al 2000;Houpert et al 2001;Martinez et al 2003). We have also demonstrated that CBMIDA is effective in removing uranium in rats (Fukuda et al 2001).…”

Section: Discussionmentioning

confidence: 83%

“…The toxic dose of depleted uranium has been examined in animals and humans (Hodge 1973;Hursh and Spoor 1973;Yulle 1973;Leggett 1989;Stradling et al 1997Stradling et al , 2003. Chelation therapy is a useful method to reduce the risk of toxicity by accelerating excretion of uranium from the body.…”

Section: Introductionmentioning

confidence: 99%

“…Various chelating agents have been examined over the years (Dagirmanjian et al 1956;Basinger and Jones 1981;Domingo et al 1989Domingo et al , 1990Stradling et al 1991;Ubios et al 1994;Hengé-Napoli et al 1995, 1998Durbin et al 1997;Martinez et al 2000Martinez et al , 2003Fukuda et al 2001;Houpert et al 2001). Ethane-1-hydroxy-1,1-bisphosphonate (EHBP), which is used as drug for hypercalcemia and osteoporosis treatments, is effective in removing uranium (Ubios et al 1994;Hengé-Napoli et al 1999;Martinez et al 2000;Houpert et al 2001;Martinez et al 2003), provided that it is not approved as the drug for uranium decorporation. Also, we demonstrated that Catechol-3,6-bis(methyleiminodiacetic acid) (CBMIDA) is effective in removing uranium (Fukuda et al 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Also, we demonstrated that Catechol-3,6-bis(methyleiminodiacetic acid) (CBMIDA) is effective in removing uranium (Fukuda et al 2001). Diethylenetriaminepentaacetate (DTPA) was not effective in removing uranium (Domingo et al 1989(Domingo et al , 1990Archimbaud et al 1994;Ubios et al 1994), although it has been recommended for years.…”

Section: Introductionmentioning

confidence: 99%

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Toxicity of Uranium and the Removal Effects of Cbmida and Ehbp in Simulated Wounds of Rats

Fukuda¹,

Iida²,

Ikeda³

et al. 2005

Health Physics

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We examined the acute toxicity of uranium (99.3% 238U, 0.7% 235U) and the effects of Catechol-3,6-bis(methyleiminodiacetic acid) (CBMIDA) and Ethane-1-hydroxy-1,1-bisphosphonate (EHBP) on the removal of uranium after intramuscular injection as a simulated wound intake in rats. In this experiment, male Wistar rats, 8 wk old, were injected intramuscularly with uranyl nitrate in the femoral muscles. Experiment I: Rats died from 3 to 7 d after they were injected with five doses of 7.9, 15.8, 31.5, 63, and 126 mg kg(-1) uranium. The uranium retained 8.4-13.6% of the injected doses in the kidneys, showing the relationship between the injected dose and the retained concentration (r = 0.997). The excretion rates of the injected doses in the 63 and 126 mg kg(-1) uranium-injected rats were 1.73% and 3.09% in urine and 0.81% and 1.06% in feces on the first day, and 0.54% and 0.56% in feces on the second day, respectively. Experiment II: The retention of uranium at 1, 3, 6, and 24 h was examined after rats were injected with 63 mg kg(-1) uranium. The concentration of uranium decreased in the plasma, while it increased in the kidneys and femur until 6 h, and it continued to increase in the liver until 24 h. Experiment III: Rats were divided into four groups (n = 10) and were injected with a dose of 2 mg kg(-1) uranium. Two of the groups were then injected intraperitoneally with 240 or 480 mg kg-1 CBMIDA, and one group was injected with 10 mg kg(-1) EHBP once daily for 28 d, beginning 1 h after uranium injection on the first day. The fourth group was the non-treated control group. The survival rates at the end of the experiment were 80% and 40% in the 240 and 480 mg kg(-1) CBMIDA groups, 50% in the EHBP group, and 20% in the non-treated group. The successive administration of chelating agents was effective in decreasing the concentration of uranium in the kidneys, bone, and liver. The results indicated that uranium induces acute death and renal dysfunction by chemical toxicity, and both CBMIDA and EHBP were effective agents to prevent these effects.

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Section: Discussionmentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Toxicity of Uranium and the Removal Effects of Cbmida and Ehbp in Simulated Wounds of Rats

Fukuda¹,

Iida²,

Ikeda³

et al. 2005

Health Physics

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“…Biokinetic behavior of several compounds of Th and U are well known (International Commission on Radiological Protection (ICRP) 1959, publication no. 2), but there is little data about the biokinetic behavior of Th and U associated to mineral crystal lattice (Dias da Cunha et al 2002;Wan et al 2006;Stradling et al 2003;Sutton and Burastero 2004;Chen et al 2005;Li et al 2007). While there are available several data about the effects of Th and U in the human body, there is very few data about Ta toxicity and these few studies are not conclusive.…”

Section: Introductionmentioning

confidence: 99%

Dissolution Factors of Ta, Th, and U Oxides Present in Pyrochlore

Cunha

Santos

Zouain

et al. 2009

Water Air Soil Pollut

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Air pollution can be a problem in industrial processes, but monitoring and controling the aerosols in the work place is not enough to estimate the occupational risk due to dust particle inhalation. The solubility in lung fluid is considered to estimate this risk. The aim of this study is to determine in vitro specific dissolution parameters for thorium (Th), uranium (U), and tantalum (Ta) associated to crystal lattice of a niobium mineral (pyrochlore). Th, U, and Ta dissolution factors in vitro were obtained using the Gamble solution (simulant lung fluid, SLF), particle induced X-ray emission, and alpha spectrometry as analytical techniques. Ta, Th, and U are present in the pyrochlore crystal lattice as oxide; however, they have shown different dissolution parameters. The rapid dissolution fraction (f r ), rapid dissolution rate (λ r ), slow dissolution rate (f s ), and slow dissolution fraction (λ s ) measured for tantalum oxide were equal to 0.1 and 0.45 and 0.00007 day −1 , respectively. For uranium oxide, f r was equal to 0.05, λ r was equal to 1.1 day −1 , and λ s was equal to 0.000068 day −1 . For thorium oxide, f r was 0.025, λ r was 1.5 day −1 , and λ s was 0.000065 day −1 . These results show that chemical behavior of these three compounds in the SLF could not be represented by the same parameter. The ratio of uranium concentration in urine and feces samples from workers exposed to pyrochlore dust particle was determined. These values agree with the theoretical values of estimated uranium concentration using specific parameters for uranium oxide present in pyrochlore.

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Uranium: Environmental Pollution and Health Effects

Melo

Burkart

2011

Encyclopedia of Environmental Health

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Anomolies between radiological and chemical limits for uranium after inhalation by workers and the public

Cited by 8 publications

References 0 publications

Toxicity of Uranium and the Removal Effects of Cbmida and Ehbp in Simulated Wounds of Rats

Toxicity of Uranium and the Removal Effects of Cbmida and Ehbp in Simulated Wounds of Rats

Dissolution Factors of Ta, Th, and U Oxides Present in Pyrochlore

Uranium: Environmental Pollution and Health Effects

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