Anomia as a marker of distinct semantic memory impairments in Alzheimer's disease and semantic dementia.

Reilly, Jamie; Peelle, Jonathan E.; Antonucci, Sharon M.; Grossman, Murray

doi:10.1037/a0022738

Cited by 77 publications

(70 citation statements)

References 138 publications

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“…Results from a selected group of patients with primary progressive aphasia and exclusive or predominant atrophy within the left ATL revealed a substantial number of anomic errors (Mesulam et al 2013). Also supporting this result, patients with semantic dementia, principally associated with atrophy in anterolateral and ventral cortex, were found to make more omissions than patients with Alzheimer's disease, primarily associated with damage to MTL (Reilly et al 2011). Additionally, when we evaluated the effects of relevant psycholinguistic factors on object naming, we found that all participants showed an influence of age of acquisition and concept familiarity (Graves et al 2007;Hirsch and Funnell 1995;Lambon Ralph et al 1998;Rogers et al 2004).…”

Section: Discussionmentioning

confidence: 65%

Visual object naming in patients with small lesions centered at the left temporopolar region

et al. 2014

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Naming is considered a left hemisphere function that operates according to a posterior-anterior specificity gradient, with more fine-grained information processed in most anterior regions of the temporal lobe (ATL), including the temporal pole (TP). Word finding difficulties are typically assessed using visual confrontation naming tasks, and have been associated with selective damage to ATL resulting from different aetiologies. Nonetheless, the role of the ATL and, more specifically, of the TP in the naming network is not completely established. Most of the accumulated evidence is based on studies on patients with extensive lesions, often bilateral. Furthermore, there is a considerable variability in the anatomical definition of ATL. To better understand the specific involvement of the left TP in visual object naming, we assessed a group of patients with an epileptogenic lesion centered at the TP, and compared their performance with that of a strictly matched control group. We also administered a battery of verbal and non-verbal semantic tasks that was used as a semantic memory baseline. Patients showed an impaired naming ability, manifesting in a certain degree of anomia and semantically related naming errors, which was influenced by concept familiarity. This pattern took place in a context of mild semantic dysfunction that was evident in different types and modalities of semantic tasks. Therefore, current findings demonstrate that a restricted lesion to the left TP can cause a significant deficit in object naming. Of importance, the observed semantic impairment was far from the devastating degradation observed in semantic dementia and other bilateral conditions.

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Section: Discussionmentioning

confidence: 65%

Visual object naming in patients with small lesions centered at the left temporopolar region

et al. 2014

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“…Underlying impairments of conceptual knowledge have been demonstrated with non-linguistic semantic tasks such as semantic matching between pictures (Bozeat, Lambon Ralph, Patterson, Garrard, & Hodges, 2000), object use (Hodges, Bozeat, Lambon Ralph, Patterson, & Spatt, 2000), sound to picture matching (Bozeat et al, 2000), picture categorization (Rogers & Patterson, 2007), knowledge of object features (Adlam et al, 2006; Rogers et al, 2004) and delayed picture copy (Patterson & Erzinçlioğlu, 2009); see Hodges and Patterson (2007) for review. Furthermore, the progression and severity of naming deficits are strongly associated with the progression and severity of the deterioration of conceptual knowledge (Adlam et al, 2006; Hodges et al, 1995; Jefferies & Lambon Ralph, 2006; Lambon Ralph, McClelland, Patterson, Galton, & Hodges, 2001; Rogers et al, 2004; Reilly, Peelle, Antonucci, & Grossman, 2011). …”

Section: Introductionmentioning

confidence: 99%

Lexical access in semantic variant PPA: Evidence for a post-semantic contribution to naming deficits

et al. 2017

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The most salient clinical symptom of semantic variant primary progressive aphasia (PPA) is a profound and pervasive anomia. These patients' naming impairments have been shown to reflect in large part a domain-general deterioration of conceptual knowledge that impacts both linguistic and non-linguistic processing. However, it is possible that post-semantic stages of lexical access may also contribute to naming deficits. To clarify the stages at which lexical access breaks down in semantic variant PPA, eleven French-speaking patients were asked to name objects, and were then queried for semantic, lexical-syntactic, and word form information pertaining to the items they could not name. Specifically, our goal was to determine whether patients can access intermediate representations known as lemmas, which mediate the arbitrary mapping between semantic representations and word forms (phonological and orthographic forms). The French language was chosen for this study because nouns in French are marked for grammatical gender, a prototypical type of lexical-syntactic information, represented at the level of the lemma. Access to word form information is also dependent on lemma access under some theoretical views. We found that six of the eleven patients showed partial access to either lexical-syntactic properties of unnamed items (grammatical gender), word form information (initial letter), or both. Access to these types of information suggests that a lemma has been retrieved, implying a breakdown at the post-semantic stage of word form retrieval. Our results suggest that although degraded conceptual knowledge is the main cause of naming deficits in semantic variant PPA, in some patients, a post-semantic component also contributes to the impairment.

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“…word retrieval, working memory and language). Examples of tests with semantic content are naming of objects [7,8] as well as naming and recognition of faces of famous people [9,10]. Some of the verbal subtests of the Wechsler Adult Intelligence Scale tap semantic memory and a more severe impairment on category than on phonological/lexical fluency tasks [11,12] may indicate impairment related to semantic memory.…”

Section: Introductionmentioning

confidence: 99%

Frequency and Severity of Semantic Deficits in a Consecutive Memory Clinic Cohort

Vogel¹,

Johannsen²,

Stokholm³

et al. 2014

Dement Geriatr Cogn Disord

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Background/Aim: Semantic memory deficits have been shown in dementia and mild cognitive impairment (MCI) by group comparisons. The aim of this study is to investigate the frequency of impairments on tests with semantic content in patients with dementia, MCI (amnestic and non-amnestic) and affective disorders. Methods: A Famous faces test, Boston Naming Test and Category fluency were applied in 114 consecutive memory clinic patients and 95 healthy participants (all participants were 60 years old or older; dementia/MCI patients had Mini-Mental State Examination scores ≥20). Results: Fifty-three patients were classified with dementia, 36 with MCI (14 amnestic, 22 non-amnestic) and 25 with affective disorders. Dementia and MCI patients differed significantly from the control group on all tests. Patients with dementia and MCI had impairments in about 40% of the cases (on the most sensitive tests). However, patients with affective disorders also had mild impairments on tests tapping semantic memory (25% were impaired on the most sensitive tests). Impairments on the Famous faces test were more frequently found in dementia and MCI as compared to patients with affective disorders. Conclusion: Short tests with semantic memory content are sensitive to changes in dementia and MCI, but impairments on such tests may also be found in other diseases, e.g. affective disorders.

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Anomia as a marker of distinct semantic memory impairments in Alzheimer's disease and semantic dementia.

Cited by 77 publications

References 138 publications

Visual object naming in patients with small lesions centered at the left temporopolar region

Visual object naming in patients with small lesions centered at the left temporopolar region

Lexical access in semantic variant PPA: Evidence for a post-semantic contribution to naming deficits

Frequency and Severity of Semantic Deficits in a Consecutive Memory Clinic Cohort

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