Anomalous sensitivity enhancement of nano-graphitic electrochemical micro-sensors with reducing the operating voltage

Unraveling the complex electrochemistry of serotonin using engineered graphitic sensors

“…They also provide sharp and well-defined redox peaks, allowing FSCV operation at low potentials inaccessible to the existing carbon sensors. 30 Our experiments provide new insights into the identity and mechanism of 5-HT side reactions, which reconcile the inconsistent past observations. Lastly, we demonstrate the application of these insights for optimizing the FSCV protocols for selective and sensitive detection of 5-HT.…”

“…The engineered structure of these graphitic carbon materials results in electrochemical sensors that produce sharp and well-defined peaks in FSCV measurements of electroactive analytes. 29,30,34 As discussed below, this unique feature allowed us to examine the effects of the FSCV potential sweep range, revealing the unexpected role of the anodic potential limit ( U a ) in driving 5-HT side reactions.…”

A Framework for Benchmarking Emerging FSCV Neurochemical Sensors

“…The details of NG sensors can be found in our previous studies. [20,21] An FSCV voltage waveform was applied to the sensor and the resulting current was recorded and subsequently analyzed for assessing the sensor performance in terms of sensitivity, selectivity, and limit of detection (LoD).…”

“…In Figure 2b, we demonstrate the utility of this performance plot by summarizing the performance data for several different types of carbon sensors reported previously in the literature. [8][9][10][11][12][13][14][15][16][17][18][19][20][21] Note that the list of chosen carbon materials in this plot is not exhaustive. We used the data from those studies that provided sufficient details for computing the SBR and ΔE p .…”

“…202300079 and investigating new forms of carbon. [12][13][14][15][16][17][18][19][20][21][22] The first step in this material discovery process is to produce sensors from a candidate carbon material and evaluate the sensor performance in vitro. However, before sensors from alternative carbon materials can be further considered for experiments in the brain, a quantitative comparison of their key performance metrics against those of CF will be insightful.…”