Anomalías en el desarrollo del cuarto aparato faríngeo como causa de infecciones profundas del cuello recidivantes

R, María de los Ángeles Contreras; R, José Miguel Contreras; S, Eduardo Reyes; W, Alejandro Paredes

doi:10.4067/s0718-48162006000300005

Cited by 2 publications

(6 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, we describe, for the first time to our knowledge, a spontaneous congenital defect in the organogenesis of UBB in a rat that had likely not detached from the hypopharynx wall during This rat UB sinus is an exceptional case that corresponds to fourth branchial apparatus anomalies described in humans, which are very scarce (1% congenital branchial anomalies) and often manifest quite late in life as a recurrent neck abscess and suppurative thyroiditis (Contreras et al, 2006;Li et al, 2020;Pal et al, 2018). Fourth branchial apparatus anomalies include three possibilities: cyst, sinus and fistula.…”

Section: Discussionmentioning

confidence: 67%

“…This rat UB sinus is an exceptional case that corresponds to fourth branchial apparatus anomalies described in humans, which are very scarce (1% congenital branchial anomalies) and often manifest quite late in life as a recurrent neck abscess and suppurative thyroiditis (Contreras et al., 2006 ; Li et al., 2020 ; Pal et al., 2018 ). Fourth branchial apparatus anomalies include three possibilities: cyst, sinus and fistula.…”

Section: Discussionmentioning

confidence: 89%

“…A fistula is a tract that communicates with the skin externally and the foregut internally (Contreras et al, 2006;Li et al, 2020;Pal et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…A cyst is an epithelial‐lined structure without an external opening; a sinus is a blind tract that opens either externally through the skin or internally into the foregut (specifically, the apex of the piriform fossa). A fistula is a tract that communicates with the skin externally and the foregut internally (Contreras et al., 2006 ; Li et al., 2020 ; Pal et al., 2018 ). Consequently, our case must correspond to a UB sinus that, similar to what happens in humans, occurred in a female rat on the left neck side, with a proximal opening likely in the hypopharynx and accompanied by ectopic thymic tissue into the thyroid lobe.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

C‐cell differentiation in the wall of an aberrant ultimobranchial sinus in the thyroid gland of an old rat

Vázquez-Román

Fernández-Santos

Martín-Lacave

2022

Veterinary Medicine & Sci

View full text Add to dashboard Cite

Background In mammals, the thyroid gland possesses two types of endocrine cells, follicular cells and C cells, which have different functions but share a similar endodermal origin (although from different regions of the primitive pharynx). Specifically, follicular cells derive from the ventral pharyngeal floor, while C cells derive from the fourth pair of pharyngeal pouches through the ultimobranchial bodies (UBBs). Disruptions to human midline thyroid morphogenesis are relatively frequent and known as thyroid dysgenesis, which is the leading cause of congenital hypothyroidism. In contrast, fourth branchial apparatus anomalies are very rare clinical entities. Objectives The aim of this study was to analyze the morphological features and the immunohistochemical pattern of an aberrant ultimobranchial remnant, align with its persistent contribution to the formation of new C cells. Methods The thyroid gland of an old rat was serially sectioned and immunostained for the following markers: calcitonin, thyroglobulin, cytokeratins, PCNA, P63, E‐cadherin, beta‐tubulin and CD3. Results We detected a spontaneous congenital defect in the organogenesis of the UBB in an old rat, giving rise to an ‘ultimobranchial sinus’, which was accompanied by thymic tissue and an abscess. The epithelium contained basal/stem cells and contributed to the formation of abundant C cells and scarce follicular cells. Conclusions The ultimobranchial sinus is an exceptional finding for representing the first spontaneous abnormality in the development of UBB reported in rats, and the opportunity to observe sustained C‐cell differentiation from stem cells in an old rat. These findings are consistent with a common origin of both C cells and follicular cells from UBB.

show abstract

Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 89%

“…A fistula is a tract that communicates with the skin externally and the foregut internally (Contreras et al, 2006;Li et al, 2020;Pal et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

C‐cell differentiation in the wall of an aberrant ultimobranchial sinus in the thyroid gland of an old rat

Vázquez-Román

Fernández-Santos

Martín-Lacave

2022

Veterinary Medicine & Sci

View full text Add to dashboard Cite

show abstract

“…En realidad, su tolerancia o no a la función simbólica del Derecho Penal depende de que siga garantizando suficientemente la referencia al bien jurídico. Dentro de la doctrina española, Cuello Contreras 115 , Peris Riera 116 , Terradillos Basoco 117 Y Luzón Peña 118 ven el peligro no en la función simbólica del Derecho Penal en sí misma, sino en que se convierta en la única función que impregne las normas penales. Si esto sucede, el Derecho Penal se convierte «en un mero difusor de ideología» 119 .…”

Section: Posturas Alrededor Del Derecho Penal Simbólicounclassified

El Patrimonio Genético De La Humanidad Como Bien Jurídico Penal

Martínez Pérez

2023

RDPC

View full text Add to dashboard Cite

show abstract

Anomalías en el desarrollo del cuarto aparato faríngeo como causa de infecciones profundas del cuello recidivantes

Cited by 2 publications

References 10 publications

C‐cell differentiation in the wall of an aberrant ultimobranchial sinus in the thyroid gland of an old rat

C‐cell differentiation in the wall of an aberrant ultimobranchial sinus in the thyroid gland of an old rat

El Patrimonio Genético De La Humanidad Como Bien Jurídico Penal

Contact Info

Product

Resources

About