Anoikis Resistance in Melanoma

The 20th International Congress of the Society for Melanoma Research

“…Anjan Venkatesh 3 ; Colm Ryan 3 ; David J. Adams 1 1 Cancer Genetics, Wellcome Sanger Institute, Hinton, Cambridge, UK; 2 Babraham Institute, Babraham, UK; 3 University College Dublin,…”

“…Harriet Kluger 1 ; Götz U. Grigoleit Fifteen patients with mucosal melanoma were enrolled; lifileucel was manufactured for all 15 (100%), and lymph nodes were the most common source of tumor tissue (47%). Twelve patients received lifileucel (median target lesion sum of diameters: 118.9 mm; median prior lines of therapy: 2 [range: [1][2][3][4][5][6]; LDH > ULN: 42%; liver and/or brain metastases: 42%). Median number of TIL infused was 26 × 10 9 cells.…”

“…Marine Lingrand 2,1 ; Rached Alkallas 3,4 ; Mathieu Lajoie et al, 2020). We found that loss-of-function (LoF) mutations in the X-linked-DEADbox RNA helicase, DDX3X, are solely found in male patients.…”

“…Nathanael R. Fillmore 1,2 ; Rebecca I. Hartman 2 The prognosis of ALM remains poor and is markedly lower than CM, with 5-and 10-year melanoma-specific survival rates of 80.3% and 67.5%, respectively. 3 With the poor survival rate of ALM, there is a critical need to characterize clinical factors associated with ALM to better identify patient populations at highest risk.…”

“…Hannah Neuendorf 1,2 ; Khoa A. Tran 1,2 ; Jacinta Simmons 1,2,3 ; Aaron G. Smith 2 ; Glen Boyle Anoikis, the type of programmed cell death (apoptosis) triggered by detachment from surrounding extracellular structures, is a physiological mechanism to prevent inappropriate cellular spreading within the body [1,2]. As an absolute requirement for metastasis, melanoma cells must develop mechanisms to resist cell death upon detachment.…”