Anogenital human papillomavirus infection in HIV-infected women (according to the results of a pilot study in the Moscow Region)

Popova, Popova A.A.; Domonova, Domonova E.A.; Vinogradova, Vinogradova N.A.; Shipulina, Shipulina O.Yu.; Well-Being, Moscow Human

doi:10.18565/epidem.2021.11.3.40-5

Cited by 2 publications

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“…These include anogenital lesions, head and neck tumors, and other types of tumors. As a result, the social and economic burden associated with HPV-associated diseases may have been significantly underestimated ( 6 ).…”

Section: Introductionmentioning

confidence: 99%

The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

et al. 2023

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IntroductionCervical cancer (CC) is a prevalent malignancy affecting women globally. The primary causative factor of CC is the high-risk oncogenic human papillomavirus (HR-HPV). However, it is noteworthy that not all women infected with HR-HPV develop cancer, indicating the potential involvement of genetic predisposition in the development of CC. This study aims to identify genetic risks and their distribution in groups of women with different epidemiological features of HR-HPV.Materials and methodsA comparison was conducted among four groups of women, comprising 218 HPV-negative women, 120 HPV-positive women, 191 women diagnosed with cervical intraepithelial neoplasia (CIN) grade 2 or 3, and 124 women diagnosed with CC. The analysis focused on four single nucleotide polymorphisms (SNPs): rs55986091 in HLA-DQB1, rs138446575 in TTC34, rs1048943 in CYP1A1, and rs2910164 in miRNA-146a.ResultsThe rs55986091-A allele exhibited a protective effect within the “CC” group when compared to the “HPV-Negative” group (OR = 0.4, 95% CI= 0.25-0.65) using a log-additive model. Additionally, similar protective effects were observed in the “CIN 2/3” group compared to the “HPV-Negative” group (OR = 0.47, 95% CI = 0.28-0.79).ConclusionThe data obtained emphasize the importance of developing PCR-based diagnostic kits for the identification of SNP alleles, particularly for rs55986091, among HR-HPV-positive women within the Russian population.

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Section: Introductionmentioning

confidence: 99%

The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

et al. 2023

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Genetic polymorphism associated with cervical cancer: a systematic review

Vinokurov

Миронов

Korchagin

et al. 2022

Journal of microbiology, epidemiology and immunobiology

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Introduction. Cervical cancer (CC) is one of the most common cancers in women. The CC etiological agent is the high-risk oncogenic human papillomavirus. In the meantime, not all women infected with this virus can develop cancer, thus suggesting that there is genetic predisposition to CC.The aim of the study was to analyze information about single nucleotide polymorphisms associated with the CC risk.Materials and methods. The performed search was focused on genome-wide association studies (GWAS) and meta-analyses conducted over the last 10 years and addressing the genetic risk of CC in the Caucasian population.Results. The most significant associations with CC were found in the following single nucleotide polymorphisms. Based on the GWAS data, they involve risk alleles rs138446575-T (OR = 2.39) TTC34; rs73728618-T (OR = 1.48) HLA-DQA1; rs3130196-C (OR = 1.4) HLA-DPB1; rs2516448-T (OR = 1.39 and 1.44) MICA and protective alleles rs9271898-A (OR = 0.64) and 9272143-C (OR = 0.65) between HLA-DRB1 and HLA-DQA1, rs55986091-A HLADQB1 (OR = 0.66). Based on the meta-analysis data, they involve genotype rs4646903-СС (OR = 4.65) CYP1A1 and protective alleles rs1801133-T (OR = 0.77) MTHFR, rs2333227-AA (OR = 0.57) MPO.Conclusion. The obtained data are critically important for development of laboratory techniques and reagent kits allowing for a personalized approach to identification of risk groups, which could benefit from compulsory vaccination and screening for pre-cancers of the cervix.

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Anogenital human papillomavirus infection in HIV-infected women (according to the results of a pilot study in the Moscow Region)

Cited by 2 publications

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The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

The genetic variant rs55986091 HLA-DQB1 is associated with a protective effect against cervical cancer

Genetic polymorphism associated with cervical cancer: a systematic review

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