Anogenital Human Papillomavirus in Sexually Abused and Nonabused Children: A Multicenter Study

Unger, Elizabeth R.; Fajman, Nancy N.; Maloney, Elizabeth M.; Onyekwuluje, Juanita; Swan, David C.; Howard, Laurie A.; Beck-Sague, Consuelo M.; Sawyer, Mary K.; Girardet, Rebecca G; Sautter, Robert L.; Hammerschlag, Margaret R.; Black, Carolyn M.

doi:10.1542/peds.2010-2247

Cited by 45 publications

(38 citation statements)

References 29 publications

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“…In bibliography, it has been referred a single case of a condyloma accumitatum of the urethral meatus in an infant, without a history of HPV infection [5]. Genital HPV infection in children seemed to behave as a sexual transmitted via abuse [9] or vertically transmitted or extragenital contact transmitted [10,11]. In our reported case, the infant's mother mentioned that she had presented …”

Section: Discussionmentioning

confidence: 67%

HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus

A¹

2013

J Genet Syndr Gene Ther

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Penile warts in infants are rare and condylomata acuminata at the urethral meatus are rarer. This is a first report of a 2.5 years infant with a condyloma acuminatum at the urethral meatus of penis that was found positive for HPV 6, by PCR analysis. Infant's mother presented warts on her hands, suggesting a possible transmission of virus from mother to infant via extragenital contact, without excluding a vertical transmission.

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Section: Discussionmentioning

confidence: 67%

HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus

A¹

2013

J Genet Syndr Gene Ther

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“…Should CSA Survivors Be Offered HPV Vaccination Upon Evaluation, if Age-Indicated? A prospective, multicenter cross-sectional study conducted among children aged 0-13 years evaluated for sexual abuse found a high genital HPV prevalence of 14% among children with definite/probable/possible CSA vs only 1% in those with no evidence of CSA [36]. In the study conducted by Gavril et al [13], described above, 34 patients were diagnosed with genital warts during the follow-up examination.…”

Section: Sexual Assault or Abuse Of Childrenmentioning

confidence: 95%

“…For HPV, 11% of children aged 0-13 years had positive HPV PCR results but no lesions following CSA [36]. Trichomonas vaginalis was detected by either WM or culture in 4% of 10-to 17-year-old girls with "evidence of hymenal estrogenization" by Gallion, et al [41], of which only 5 of 12 had symptoms of vaginal discharge upon presentation.…”

Section: Sexual Assault or Abuse Of Childrenmentioning

confidence: 98%

Section: Key Question 6 Should Adult and Adolescent Sexual Assaultmentioning

confidence: 99%

“…Data regarding HPV infections in SA survivors have been reported from a prospective, multicenter cross-sectional study involving young girls evaluated for sexual abuse [36]. The investigators found an HPV prevalence of 11.8% overall, with a higher HPV prevalence by PCR detection associated with age ≥10 years, presence of genital warts, and evidence of sexual abuse [36]. Given this high HPV prevalence and the known consequences from infection, HPV vaccination for female SA survivors aged 9-26 years should be considered at the time of the initial examination if they have not been previously vaccinated.…”

Section: Key Question 6 Should Adult and Adolescent Sexual Assaultmentioning

confidence: 99%

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Sexual Assault and Sexually Transmitted Infections in Adults, Adolescents, and Children

et al. 2015

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Survivors of sexual assault are at risk for acquiring sexually transmitted infections (STIs). We conducted literature reviews and invited experts to assist in updating the sexual assault section for the 2015 Centers for Disease Control and Prevention sexually transmitted diseases (STD) treatment guidelines. New recommendations for STI management among adult and adolescent sexual assault survivors include use of nucleic acid amplification tests (NAATs) for detection of Trichomonas vaginalis by vaginal swabs; NAATs for detection of Neisseria gonorrhoeae and Chlamydia trachomatis from pharyngeal and rectal specimens among patients with a history of exposure or suspected extragenital contact after sexual assault; empiric therapy for gonorrhea, chlamydia, and trichomoniasis based on updated treatment regimens; vaccinations for human papillomavirus (HPV) among previously unvaccinated patients aged 9-26 years; and consideration for human immunodeficiency virus (HIV) nonoccupational postexposure prophylaxis using an algorithm to assess the timing and characteristics of the exposure. For child sexual assault (CSA) survivors, recommendations include targeted diagnostic testing with increased use of NAATs when appropriate; routine follow-up visits within 6 months after the last known sexual abuse; and use of HPV vaccination in accordance with national immunization guidelines as a preventive measure in the post-sexual assault care setting. For CSA patients, NAATs are considered to be acceptable for identification of gonococcal and chlamydial infections from urine samples, but are not recommended for extragenital testing due to the potential detection of nongonococcal Neisseria species. Several research questions were identified regarding the prevalence, detection, and management of STI/HIV infections among adult, adolescent, and pediatric sexual assault survivors.

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Maltreatment, Physical and Sexual Abuse

Herrmann

2019

Harper's Textbook of Pediatric Dermatology

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Anogenital Human Papillomavirus in Sexually Abused and Nonabused Children: A Multicenter Study

Abstract: HPV detection was associated with CSA and increased with CSA certainty. In this population, genital HPV seemed to behave as a sexually transmitted infection.

Cited by 45 publications

References 29 publications

HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus

HPV6 Infection of an Infant’s Penile Condyloma at the Urethral Meatus

Sexual Assault and Sexually Transmitted Infections in Adults, Adolescents, and Children

Maltreatment, Physical and Sexual Abuse

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