Anogenital granulomatosis: report of two cases

Abstract

Anogenital granulomatosis (AGG) is a rare chronic inflammatory disorder of unknown aetiology. It presents clinically with swelling of the genital or anoperineal area, with histopathological findings of noncaseating giant cell granulomas. Some cases of AGG are associated with underlying systemic disease, mainly Crohn disease. We report two patients with AGG. The first was a young man with ulcerative colitiis treated with infliximab, which also alleviated the developing symptoms of AGG. The second was a young woman who was otherwise healthy. After the introduction of complex decongestive therapy, the oedema was considerably reduced in both patients.

Ano-genital Granulomatosis and Crohn’s Disease: A Case Series of Males Presenting with Genital Lymphoedema

“…Previous case reports have indicated response in both patients with AGG, with and without intestinal CD. 5,16 Conclusion Ano-genital granulomatosis is a rare condition and usually presents with penile and scrotal lymphoedema in males. Unless the clinician is vigilant, there may be a protracted delay in diagnosis.…”

Grotesque vulva – a clinician's diagnostic dilemma

“…1 EoE similarly involves a type 2 inflammatory response and shares genetic susceptibility loci with other atopic diseases. 1,3 Dupilumab, an anti-IL-4 receptor alpha antibody used in AD, is now approved for EoE, suggesting common immunopathology for the conditions. 4 Demonstrating that AD represents a risk factor for EoE may encourage screening for EoE in individuals with AD who develop esophageal symptoms to prevent serious sequelae such as dysphagia, esophageal strictures, and food impaction.Better characterizing the relationship between AD and EoE will facilitate optimal management of both conditions, and future studies may investigate whether certain treatments are ideal in individuals with both AD and EoE.…”

“…Some cases of AGG are found to be associated with Crohn's disease (CD) and may precede intestinal disease in 20% to 36% of patients due to asymptomatic intestinal involvement that goes unnoticed or due to delayed onset of enteropathy. 1 Rarely, AGG patients may present in absence of gastrointestinal CD. Herein we report one such case.…”

Idiopathic granulomatous vulvitis and subsequent oral granulomatosis: a diagnostic and therapeutic challenge

“…Additionally, oral involvement is described as cheilitis granulomatosa . As isolated GV/AGG may precede subsequent CD, careful and continued follow‐up is essential …”