Anodic oxide films containing Ca and P of titanium biomaterial

Zhu, Xiaolong; Kim, Kyo-Han; Jeong, Yongsoo

doi:10.1016/s0142-9612(00)00394-x

Cited by 208 publications

(150 citation statements)

References 27 publications

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“…This method, which increases surface roughness, forms TiO 2 on the surface through the oxidation process, and incorporates calcium or phosphorus ions into the surface layer, and is beneficial to osteoblastic cell activity [1,21,22,38]. MAO forms a relatively thick TiO 2 layer by applying a positive voltage above a certain point to the titanium [22].…”

Section: Discussionmentioning

confidence: 99%

“…Microarc oxidation (MAO) provides nanoporous pits, thick oxide layers, and the incorporation of calcium and phosphorus into the coating layer which results in improved osteoblast cell responses, such as an enhanced rate of actin, vinculin cytoskeletal reorganization, and the formation of integrins mediating osteoblast adhesion [7,14,23,37,38]. The average roughness of a Ti-alloy surface, treated by the MAO process, is about 0.3 to 0.5 lm [22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced Cell Integration to Titanium Alloy by Surface Treatment with Microarc Oxidation: A Pilot Study

Lim

Kwon

Sun

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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Microarc oxidation (MAO) is a surface treatment that provides nanoporous pits, and thick oxide layers, and incorporates calcium and phosphorus into the coating layer of titanium alloy. We presumed such modification on the surface of titanium alloy by MAO would improve the ability of cementless stems to osseointegrate. We therefore compared the in vitro ability of cells to adhere to MAOed titanium alloy to that of two different types of surface modifications: machined and grit-blasted. We performed energy-dispersive x-ray spectroscopy and scanned electron microscopy investigations to assess the structure and morphology of the surfaces. Biologic and morphologic responses to osteoblast cell lines (SaOS-2) were then examined by measuring cell proliferation, cell differentiation (alkaline phosphatase activity), and avb3 integrin. The cell proliferation rate, alkaline phosphatase activity, and cell adhesion in the MAO group increased in comparison to those in the machined and grit-blasted groups. The osteoblast cell lines of the MAO group were also homogeneously spread on the surface, strongly adhered, and well differentiated when compared to the other groups. This method could be a reasonable option for treating the surfaces of titanium alloy for better osseointegration.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Enhanced Cell Integration to Titanium Alloy by Surface Treatment with Microarc Oxidation: A Pilot Study

Lim

Kwon

Sun

et al. 2009

Clinical Orthopaedics &Amp; Related Research

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“…Highly adhesive anodic oxides can be formed through anodization, and the composition of these anodic films is dependent on electrolyte composition [33]. Electrolytes containing calcium and phosphorus have been explored as a means of forming anodic films [33][34][35].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial iodine-supported titanium implants

et al. 2011

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Deep infection remains a serious complication in orthopedic implant surgery. In order to reduce the incidence of implant-associated infections, several biomaterial surface treatments have been proposed. This study focused on evaluating the antibacterial activity of iodine-supported titanium (Ti-I 2 ) and impact on post-implant infection, as well as determining the potential suitability of Ti-I 2 as a biomaterial.External fixation pins were used in this experiment as trial implants because it was easy to make the septic models.The antibacterial activity of the metal was measured using a modification of the Japanese Industrial Standards method. Activity was evaluated by exposing the implants to Staphylococcus aureus or Escherichia coli and comparing reaction of pathogens to the Ti-I 2 versus the stainless steel and titanium controls. The Ti-I 2 clearly inhibited bacterial colonization more than the control metals. In addition, cytocompatibility was assessed by counting the number of colonies that formed on the metals. The three metals showed the same amount of fibroblast colony formation.Japanese white rabbits were used as an in vivo model. Three pins were inserted into both femora of six rabbits for histological analysis. Pin sites were inspected and graded for infection and inflammation. Fewer signs of infection and inflammatory changes were observed in conjunction with the Ti-I 2 pins. Furthermore, osteoconductivity of the implant was evaluated with osteoid formation surface of the pin. Consecutive bone formation was observed around the Ti-I 2 and titanium pins, while little osteoid formation was found around the stainless steel pins. These findings suggest that Ti-I 2 has antimicrobial activity and cytocompatibility.Therefore, Ti-I 2 substantially reduces the incidence of implant infection and shows particular promise as a biomaterial.

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“…The surface containing Ca and P leads to osseoinduction of new bones and becomes bioactive. The Ca/P ratio should be near 1.67 in the anodic film to represent a bioactive surface [24][25][26] . Bioactivity can be evaluated by in vitro tests.…”

Section: Abstract: Ti6al4v Thin Films Eis Bioactivity Electrochemimentioning

confidence: 99%

“…The topography was studied by Zhu et al and the composition and structure of the titanium anodic films in calcium glycerophosphate and calcium acetate resulted in a porous and crystalline oxide rich in Ca and P 24 .…”

Section: Abstract: Ti6al4v Thin Films Eis Bioactivity Electrochemimentioning

confidence: 99%

Electrochemical Stability and Bioactivity Evaluation of Ti6Al4V Surface Coated with Thin Oxide by EIS for Biomedical Applications

2015

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Anodic oxide films containing Ca and P of titanium biomaterial

Cited by 208 publications

References 27 publications

Enhanced Cell Integration to Titanium Alloy by Surface Treatment with Microarc Oxidation: A Pilot Study

Enhanced Cell Integration to Titanium Alloy by Surface Treatment with Microarc Oxidation: A Pilot Study

Antibacterial iodine-supported titanium implants

Electrochemical Stability and Bioactivity Evaluation of Ti6Al4V Surface Coated with Thin Oxide by EIS for Biomedical Applications

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