Anodal tDCS Enhances Verbal Episodic Memory in Initially Low Performers

Habich, Annegret; Klöppel, Stefan; Abdulkadir, Ahmed; Scheller, Elisa; Nissen, Christoph; Peter, Jessica

doi:10.3389/fnhum.2017.00542

Cited by 30 publications

(41 citation statements)

References 70 publications

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“…In contrast to previous studies that found stronger tDCS effects on low performers [23][24][25]53], the high performers in our study showed the anticipated tDCS effect. It is important to note that none of the studies applied comparable tasks, stimulation timing, or stimulation sites.…”

Section: Discussioncontrasting

confidence: 99%

“…The moderation model explained a substantial amount of the 70% of the explained variance. In the study of Habich et al [23], just 50% of the variance was explained. Moreover, the tDCS effect on consolidation increased the explained variance by 6%; the 7% in our study is comparable.…”

Section: Discussionmentioning

confidence: 91%

“…We tested our main hypothesis, namely improved sleep-dependent memory consolidation in the active tDCS compared to sham, with a moderation analysis [23]. We used the SPSS PROCESS macro (version 3.0 [50]), to test the moderating effect of baseline retrieval on the tDCS effect as assessed by the delayed retrieval performance.…”

Section: Tdcs Effectsmentioning

confidence: 99%

“…Additionally, negative findings in healthy participants might have obscured an effect of individual baseline performance on responsiveness to TES. A number of studies have found that baseline performance of study participants might modulate the stimulation effect on the outcome performance [23][24][25][26]. Taken together, these examples suggest an efficacy-dependent brain-trait and brain-state variability of TES [27].…”

Section: Introductionmentioning

confidence: 99%

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Bi-temporal anodal tDCS during slow-wave sleep boosts episodic memory consolidation in high performers

Grieder¹,

Morishima²,

Winkelbeiner³

et al. 2019

Preprint

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Background: Sleep is crucial for sound memory functioning in humans. In particular, the slow waves that occur predominantly during slow wave sleep (SWS) are associated with hippocampus-dependent declarative memory consolidation. Making use of this association, boosting SWS to improve memory performance would be appealing for both healthy and memory-impaired populations. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation that modulates the brain’s excitability and has shown promising results in improving memory performance. However, owing to differing stimulation protocols and contradictory findings, there is insufficient evidence for the efficacy of tDCS-modulated hippocampal excitability on SWS and sleep-dependent memory consolidation.Hypotheses: We aimed to enhance sleep-dependent memory consolidation and augment slow wave amplitudes.Methods: We applied bi-temporal anodal tDCS to the left and right lateral temporal lobes of 31 healthy participants in a double-blind, sham-controlled, randomized crossover study. State-dependent tDCS was administered during slow wave sleep only. A pair-associate episodic memory task was used to assess sleep-dependent memory consolidation with face-occupation stimuli with baseline retrieval before sleep and delayed retrieval after sleep.Results: Sleep-dependent memory consolidation was increased by tDCS only in participants who showed above-average performance (i.e. high performers) in baseline memory retrieval. Moreover, tDCS increased the slow wave amplitudes compared to sham.Conclusions: When targeting a specialized brain mechanism such as memory consolidation with tDCS during slow wave sleep, only those who were high performers at baseline achieved a memory boost.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 91%

Section: Tdcs Effectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bi-temporal anodal tDCS during slow-wave sleep boosts episodic memory consolidation in high performers

Grieder¹,

Morishima²,

Winkelbeiner³

et al. 2019

Preprint

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show abstract

“…In contrast, a study examining anodal tDCS to the left DLPFC during face-name associative encoding only observed subsequent recall and recognition memory benefits in younger adults but no such improvements in older adults (Leach, McCurdy, Trumbo, Matzen, & Leshikar, 2018). Given that older adults are typically poorer performers on memory tasks, this result is seemingly at odds with that of another study involving anodal tDCS to the left DLPFC that found that verbal episodic memory performance was most improved in those participants who were initially poor performers (Habich et al, 2017). In an effort to leverage the power of converging methodologies, Lu, Wang, Chen, and Xue (2015) combined EEG and tDCS and found that greater spatiotemporal neural pattern similarity for repeated presentations of individual items measured with EEG at encoding could be used to predict subsequent memory performance.…”

Section: Discussionmentioning

confidence: 85%

Anodal Transcranial Direct Current Stimulation to the Left Rostrolateral Prefrontal Cortex Selectively Improves Source Memory Retrieval

Westphal

Chow

Ngoy

et al. 2019

Journal of Cognitive Neuroscience

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Functional neuroimaging studies have consistently implicated the left rostrolateral prefrontal cortex (RLPFC) as playing a crucial role in the cognitive operations supporting episodic memory and analogical reasoning. However, the degree to which the left RLPFC causally contributes to these processes remains underspecified. We aimed to assess whether targeted anodal stimulation—thought to boost cortical excitability—of the left RLPFC with transcranial direct current stimulation (tDCS) would lead to augmentation of episodic memory retrieval and analogical reasoning task performance in comparison to cathodal stimulation or sham stimulation. Seventy-two healthy adult participants were evenly divided into three experimental groups. All participants performed a memory encoding task on Day 1, and then on Day 2, they performed continuously alternating tasks of episodic memory retrieval, analogical reasoning, and visuospatial perception across two consecutive 30-min experimental sessions. All groups received sham stimulation for the first experimental session, but the groups differed in the stimulation delivered to the left RLPFC during the second session (either sham, 1.5 mA anodal tDCS, or 1.5 mA cathodal tDCS). The experimental group that received anodal tDCS to the left RLPFC during the second session demonstrated significantly improved episodic memory source retrieval performance, relative to both their first session performance and relative to performance changes observed in the other two experimental groups. Performance on the analogical reasoning and visuospatial perception tasks did not exhibit reliable changes as a result of tDCS. As such, our results demonstrate that anodal tDCS to the left RLPFC leads to a selective and robust improvement in episodic source memory retrieval.

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Effective connectivity during autobiographical memory search

Nawa

Ando

2020

Brain and Behavior

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Introduction We used dynamic causal modeling (DCM) to examine effective connectivity during cued autobiographical memory (AM) search in a left‐hemispheric network consisting of six major regions within the large network of brain regions recruited during memory retrieval processes. Methods Functional MRI data were acquired while participants were shown verbal cues describing common life events and requested to search for a personal memory associated with the cue. We examined directed couplings between the ventromedial (vmPFC), dorsomedial (dmPFC), and dorsolateral prefrontal cortices (dlPFC), hippocampus, angular gyrus, and the posterior midline cortex (RSC/PCC/Prec). Results During AM search, the vmPFC, dlPFC, and RSC/PCC/Prec acted as primary drivers of activity in the rest of the network. Moreover, when AM search completed successfully (Hits), the effective connectivity of the hippocampus on the vmPFC and angular gyrus was up‐modulated. Likewise, there was an increase in the influence of the RSC/PCC/Prec in the activity of the dlPFC and dmPFC. Further analysis indicated that the modulation observed during Hits is primarily a distributed phenomenon that relies on the interplay between different brain regions. Conclusion These results suggest that prefrontal and posterior midline cortical regions together with the dlPFC largely coordinate the processes underlying AM search, setting up the conditions on which the angular gyrus and the hippocampus may act upon when the outcome of the search is successful.

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Anodal tDCS Enhances Verbal Episodic Memory in Initially Low Performers

Cited by 30 publications

References 70 publications

Bi-temporal anodal tDCS during slow-wave sleep boosts episodic memory consolidation in high performers

Bi-temporal anodal tDCS during slow-wave sleep boosts episodic memory consolidation in high performers

Anodal Transcranial Direct Current Stimulation to the Left Rostrolateral Prefrontal Cortex Selectively Improves Source Memory Retrieval

Effective connectivity during autobiographical memory search

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