Anoctamin 1 and c-Kit immunohistochemical study of interstitial cells of Cajal in the muscularis externa of human gastrointestinal tract

Atteya, Muhammad; Ahmed, Raeesa; Alahmadi, Ahlam A.; Al-Matrafi, T A; Al-Fayez, Musaed

doi:10.5603/fm.a2021.0138

Cited by 5 publications

(1 citation statement)

References 55 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The Ca 2+ -activated Cl − channel ANO1 in ICC plays a crucial role in regulating pacemaker activity and responses to intestinal neurotransmitters ( 38 , 39 ). It is primarily expressed in epithelial cells, smooth muscle cells, and sensory neurons ( 39 – 41 ), forming calcium-activated chloride channels in the cell membrane, and is considered a more specific ICC marker than c-Kit, as it does not label mast cells ( 42 , 43 ). ANO1 has been shown to be significantly expressed in ICC and generate spontaneous transient inward currents in ICC ( 38 , 44 ), generating slow waves in intact gastrointestinal smooth muscle ( 36 , 44 ).…”

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of interstitial cells of Cajal research

Li,

Xiao,

Zhou

et al. 2024

Front. Med.

View full text Add to dashboard Cite

ObjectiveThe significance of interstitial cells of Cajal (ICC) in the gastrointestinal tract has garnered increasing attention. In recent years, approximately 80 articles on ICC have been published annually in various journals. However, no bibliometric study has specifically focused on the literature related to ICC. Therefore, we conducted a comprehensive bibliometric analysis of ICC to reveal dynamic scientific developments, assisting researchers in exploring hotspots and emerging trends while gaining a global perspective.MethodsWe conducted a literature search in the Web of Science Core Collection (WoSCC) from January 1, 2013, to December 31, 2023, to identify relevant literature on ICC. We employed bibliometric software, namely VOSviewer and CiteSpace, to analyze various aspects including annual publication output, collaborations, research hotspots, current status, and development trends in this domain.ResultsA total of 891 English papers were published in 359 journals by 928 institutions from 57 countries/regions. According to the keyword analysis of the literature, researchers mainly focused on “c-Kit,” “expression,” “smooth muscle,” and “nitric oxide” related to ICC over the past 11 years. However, with “SIP syncytium,” “ANO1,” “enteric neurons,” “gastrointestinal stromal tumors (GIST),” and “functional dyspepsia (FD),” there has been a growing interest in the relationship between ANO1, SIP syncytium, and ICC, as well as the role of ICC in the treatment of GIST and FD.ConclusionBibliometric analysis has revealed the current status of ICC research. The association between ANO1, SIP syncytium, enteric neurons and ICC, as well as the role of ICC in the treatment of GIST versus FD has become the focus of current research. However, further research and collaboration on a global scale are still needed. Our analysis is particularly valuable to researchers in gastroenterology, oncology, and cell biology, providing insights that can guide future research directions.

show abstract

Section: Discussionmentioning

confidence: 99%

A bibliometric analysis of interstitial cells of Cajal research

Li,

Xiao,

Zhou

et al. 2024

Front. Med.

View full text Add to dashboard Cite

show abstract

Ameliorating effects of transcutaneous auricular vagus nerve stimulation on a mouse model of constipation-predominant irritable bowel syndrome

Liu,

Dai,

et al. 2024

Neurobiology of Disease

View full text Add to dashboard Cite

Advancing peristalsis deciphering in mouse small intestine by multi-parameter tracking

Sasidharan,

Peethambar,

Kumar

et al. 2023

Commun Biol

View full text Add to dashboard Cite

Assessing gastrointestinal motility lacks simultaneous evaluation of intraluminal pressure (ILP), circular muscle (CM) and longitudinal muscle (LM) contraction, and lumen emptying. In this study, a sophisticated machine was developed that synchronized real-time recordings to quantify the intricate interplay between CM and LM contractions, and their timings for volume changes using high-resolution cameras with machine learning capability, the ILP using pressure transducers and droplet discharge (DD) using droplet counters. Results revealed four distinct phases, BPhase, NPhase, DPhase, and APhase, distinguished by pressure wave amplitudes. Fluid filling impacted LM strength and contraction frequency initially, followed by CM contraction affecting ILP, volume, and the extent of anterograde, retrograde, and segmental contractions during these phases that result in short or long duration DD. This comprehensive analysis sheds light on peristalsis mechanisms, understand their sequence and how one parameter influenced the other, offering insights for managing peristalsis by regulating smooth muscle contractions.

show abstract

Anoctamin 1 and c-Kit immunohistochemical study of interstitial cells of Cajal in the muscularis externa of human gastrointestinal tract

Abstract: This article has been peer reviewed and published immediately upon acceptance.It is an open access article, which means that it can be downloaded, printed, and distributed freely, provided the work is properly cited. Articles in "Folia Morphologica" are listed in PubMed.

Cited by 5 publications

References 55 publications

A bibliometric analysis of interstitial cells of Cajal research

A bibliometric analysis of interstitial cells of Cajal research

Ameliorating effects of transcutaneous auricular vagus nerve stimulation on a mouse model of constipation-predominant irritable bowel syndrome

Advancing peristalsis deciphering in mouse small intestine by multi-parameter tracking

Contact Info

Product

Resources

About