Annular neutrophilic dermatoses

Koska, Mahmut Can; Karadağ, Ayşe Serap; Durdu, Murat

doi:10.1016/j.clindermatol.2023.07.003

Cited by 3 publications

(1 citation statement)

References 107 publications

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“…The role of this inflammasome in mediating cutaneous immunity is also apparent from the enhanced sensitivity of mice with keratinocyte-selective deletion of Nlrp10 to contact dermatitis [116]. Drugs targeting inflammasome activation or outcome, such as colchicine and Anakinra, are used to treat several inflammatory skin diseases, including neutrophilic dermatoses and hidradenitis suppurativa [117,118]. Various clinical trials targeting IL-1 family cytokines to ameliorate dermatological conditions have been initiated and are reviewed elsewhere [119].…”

Section: Pyroptosismentioning

confidence: 99%

Cell death as an architect of adult skin stem cell niches

Lecomte,

Toniolo,

Hoste

2024

Cell Death Differ

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Our skin provides a physical and immunological barrier against dehydration and environmental insults ranging from microbial attacks, toxins and UV irradiation to wounding. Proper functioning of the skin barrier largely depends on the interplay between keratinocytes- the epithelial cells of the skin- and immune cells. Two spatially distinct populations of keratinocyte stem cells (SCs) maintain the epidermal barrier function and the hair follicle. These SCs are inherently long-lived, but cell death can occur within their niches and impacts their functionality. The default cell death programme in skin is apoptosis, an orderly and non-inflammatory suicide programme. However, recent findings are shedding light on the significance of various modes of regulated necrotic cell death, which are lytic and can provoke inflammation within the local skin environment. While the presence of dying cells was generally regarded as a mere consequence of inflammation, findings in various human dermatological conditions and experimental mouse models of aberrant cell death control demonstrated that cell death programmes in keratinocytes (KCs) can drive skin inflammation and even tumour initiation. When cells die, they need to be removed by phagocytosis and KCs can function as non-professional phagocytes of apoptotic cells with important implications for their SC capacities. It is becoming apparent that in conditions of heightened SC activity, distinct cell death modalities differentially impact the different skin SC populations in their local niches. Here, we describe how regulated cell death modalities functionally affect epidermal SC niches along with their relevance to injury repair, inflammatory skin disorders and cancer.

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Section: Pyroptosismentioning

confidence: 99%

Cell death as an architect of adult skin stem cell niches

Lecomte,

Toniolo,

Hoste

2024

Cell Death Differ

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Rheumatoid neutrophilic dermatitis: A case report and review of the literature

Scotti,

Misciali,

Merli

et al. 2024

JEADV Clinical Practice

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Rheumatoid neutrophilic dermatitis (RND) is a dermatological condition typically associated with rheumatoid arthritis (RA). The low prevalence of RND and the wide spectrum of its possible clinical appearances make the diagnosis challenging. Current literature is still lacking a comprehensive overview of this rare cutaneous disorder. The aim of this review is to summarize data from the existing literature on RND, focusing on its epidemiology, clinical manifestations, histopathology and treatment. Hence, a comprehensive literature search of case reports and series was made, starting from a Medline (via PubMed) and Scopus databases. We also included in the analysis one patient attending to our dermatology department and diagnosed with RND. Overall, 54 cases of RND were identified. The majority of patients were female (72.3%) with a median (IQR) age at the time of diagnosis of 58 (65‐45) years. RND followed the onset of RA in 87% of patients with an average (SD) latency time of approximately 10 (8.9) years. In 1 (1.8%) case the dermatitis preceded the appearance of joint symptoms, while in three (5.5%) cases it occurred concomitantly with them. Seropositive RA was the major associated form (76.5%). Clinically, asymptomatic papules (31%), nodules (15.1%) and/or plaques (13.5%) distributed bilaterally on extremities were most frequently described. Notably, females were more prone to develop a painful dermatitis (84.6%) compared to males. The vesicobullous (12.7%) and pustular (9.2%) clinical subtypes were the most demonstrative in contrast to the urticarial skin manifestations and the potential figurative/annular distribution of the lesions. Spontaneous resolution of RND was rare (5.5%). Systemic treatments, mainly represented by steroids and anti‐neutrophilic agents (dapsone, colchicine), were consistently required.

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Annular lesions of the skin: Diagnosis and management part II

Karadağ

2023

Clinics in Dermatology

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Annular neutrophilic dermatoses

Cited by 3 publications

References 107 publications

Cell death as an architect of adult skin stem cell niches

Cell death as an architect of adult skin stem cell niches

Rheumatoid neutrophilic dermatitis: A case report and review of the literature

Annular lesions of the skin: Diagnosis and management part II

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