Annular lesions in congenital syphilis.

Early congenital syphilis and erythema multiforme–like bullous targetoid lesions in a 1-day-old newborn: Detection of Treponema pallidum genomic DNA from the targetoid plaque using nested polymerase chain reaction

“…Although early congenital syphilis is comparable to the second stage of acquired syphilis because treponemes disseminate throughout the fetus, 5 annular lesions frequently seen in secondary syphilis are rarely reported in congenital syphilis. Agarwal et al 16 reported a 1-year-old female infant with congenital syphilis presenting with well-defined, hyperpigmented, scaly and annular lesions with central clearing on the wrist, buttocks, and popliteal fossae. Interestingly, among the literature we reviewed, there were no reports describing early congenital syphilis with targetoid skin lesions.…”

A rare presentation of congenital syphilis: Pemphigus syphiliticus in a newborn infant with extensive desquamation of the extremities

“…Mucocutaneous findings can be present in as many as 70% of infants with congenital syphilis, but the eruption is classically described as small, copper‐red maculopapular lesions that are most prominent on the back, buttocks, thighs, and soles, similar to those seen in secondary syphilis in adults . Other reported lesion types of congenital syphilis include condylomata lata, annular, and erythema multiforme‐like targetoid . The timeline of clinical manifestations is also variable.…”

“…6 Other reported lesion types of congenital syphilis include condylomata lata, annular, and erythema multiforme-like targetoid. [14][15][16][17] The timeline of clinical manifestations is also variable. Early congenital syphilis occurs within the first 2 years of life, whereas late congenital syphilis emerges in children older than 2 years.…”

Congenital Syphilis Presenting with a Generalized Bullous and Pustular Eruption in a Premature Newborn

“…They are usually found on the buttock, thighs, palms and soles, and all mucocutaneous lesions and discharge contain abundant spirochetes and are highly contagious. Other variable mucocutaneous manifestations of congenital syphilis have been reported, including vesiculobullous lesions 6 , condylomata lata lesions 7 , and annular 8 and erythema multiforme-like lesions 9 . A rare bullous variant, known as syphilitic pemphigus , most commonly occurs on palms and soles, but may be generalized.…”