Annular Elastolytic Giant‐Cell Granuloma

Lim, Kheng-Jim; Phay, K. L.

doi:10.1111/j.1365-4362.1987.tb00595.x

Cited by 2 publications

(2 citation statements)

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“…There are approximately 30 reported cases of AEGCG in the literature 1 –3 . 5 , 11 , 13 –22 Most frequently reported lesions are solitary or multiple (maximum 10) annular or ring‐shaped patches with elevated borders of 1–6 cm diameter. As this type of lesion is the common denominator in cases reported as actinic granuloma (O'Brien), 23 Miescher's granuloma of the face 24 and atypical necrobiosis lipoidica (NL) of the face and scalp, 25 one could suggest that these represent the same entity or different clinical expressions in the spectrum of elastolytic disorders 1 .…”

Section: Discussionmentioning

confidence: 99%

Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine

Özkaya‐Bayazit¹,

Büyükbabanı

Baykal³

et al. 1999

British Journal of Dermatology

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Annular elastolytic giant cell granuloma is a rare granulomatous skin disease characterized by phagocytosis of elastic fibres by multinucleated giant cells. Lesions are either solitary or grouped in a few annular patches with elevated borders and central atrophy. Sun-exposed areas are more commonly involved than covered skin. The pathogenesis of the disease is still controversial. We report a 72-year-old fair-skinned woman with unusual clinical findings. An irregularly shaped erythematous plaque covered the entire face, and hundreds of lichenoid papules were present on both sun-exposed and covered areas which gradually evolved into annular lesions of about 0.5-1 cm in diameter. Sparing of an old burn scar and a nearly complete lack of elastic fibres in the scar site were noted, illustrating the presumed importance of dermal elastic tissue in the pathogenesis. The course of the disease is chronic. Several treatments have been tried, with variable success. In our patient, improvement was achieved with chloroquine over a period of 16 weeks.

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Section: Discussionmentioning

confidence: 99%

Annular elastolytic giant cell granuloma: sparing of a burn scar and successful treatment with chloroquine

Özkaya‐Bayazit¹,

Büyükbabanı

Baykal³

et al. 1999

British Journal of Dermatology

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show abstract

“…Chronic actinic damage of elastic fibers is considered to be the triggering factor for AEGCG. [6] Studies have shown that actinically damaged elastic fibers become antigenic, and 67 kDa elastin receptors are expressed by the epitheloid cells and the giant cells in the granuloma along with Factor XIIIa + dendritic cells and CD 68+ macrophages. [2][3][4] AEGCG has been associated with acute myelogenous leukemia, CD4 T-cell lymphoma, adult T-cell leukemia, cutaneous amyloidosis and squamous cell carcinoma of the lung.…”

Section: Discussionmentioning

confidence: 99%