In this article, the command filter based adaptive event-triggered control problem for multiple-input and multiple-output multiple time-delay stochastic nonlinear systems is considered. First, a state observer is constructed to estimate the unmeasured states of systems. Then, in the framework of backstepping design, the command filtered and event-triggered techniques are employed to avoid the problem of "explosion of complexity" and save the communication resources, respectively. Meanwhile, by utilizing the command filters, a novel variable separation method is constructed to address the algebraic-loop problem, which caused by the nonstrict-feedback item. The boundedness of the whole signals in systems can be remained, and the given desired trajectories can be followed by the system outputs. Finally, a numerical example is shown to demonstrate the effectiveness of the proposed control method.