Annual skeletal balance and metabolic bone marker changes in healthy early postmenopausal women: results of a prospective study

Mazzuoli, G. F.; Acca, M; Pisani, Daniela; Diacinti, Daniele; Scarda, A.; Scarnecchia, L.; Pacitti, M. T.; D'Erasmo, E; Minisola, Salvatore; Bianchi, Giuseppe; Manfredi, Giuseppe

doi:10.1016/s8756-3282(00)00242-8

Cited by 34 publications

(18 citation statements)

References 22 publications

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“…But, the resorption rate is decreasing after 10 years of the onset of menopause. Mazzouli et al [5] also reported that bone resorption prevails over bone formation in the first 2 YSM, whereas the osteoblastic activity relatively prevails from YSM 3 to YSM 5. In the present study, the rate of bone resorption dominates bone formation in first 10 years after menopause, whereas in next 10 years the mineralization activity of osteoblasts becomes more or less equal to osteoclasts activity.…”

Section: Discussionmentioning

confidence: 96%

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Influence of years since menopause on bone mineral metabolism in South Indian women

Suresh

Naidu

2006

Indian J Med Sci

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BACKGROUND: Although an increase of bone turnover has been documented at the time of menopause, the subsequent abnormalities of bone resorption and formation in the elder women have not been investigated. AIM: To assess bone turnover among different YSM (years since menopause) groups of postmenopausal women. SETTINGS AND DESIGN: A case control study in a tertiary care hospital. MATERIALS AND METHODS: Forty-seven premenopausal (control) women and 257 postmenopausal women were included in this study. Based on YSM, the postmenopausal women were divided into four groups namely, 1-5 YSM (n=82), 6-10 YSM (n=77), 11-15 YSM (n=58) and >15 YSM (n=40). The levels of calcium, phosphorus, total alkaline phosphatase, FSH, LH, estradiol, intact-paratharmone and 25-hydroxy vitamin D in serum and urine levels of calcium, phosphorus and bone resorption marker calcium/creatinine(Ca/Cre) ratios were analyzed in all subjects. STATISTICAL ANALYSIS USED: One way ANOVA followed by Duncan's multiple range test. RESULTS: Significantly increased levels of FSH (P<0.001) and declined levels of urine calcium (P=0.015) and Ca/Cre ratios (P=0.006) were observed in >15 YSM group over 1-5 and 6-10 YSM groups. An inverse correlation was observed between serum FSH levels and urine Ca/Cre ratios (r = -0.655, P<0.001) in >15 YSM group. Comparable deficient estradiol levels were observed in all YSM groups. CONCLUSIONS: The risk of bone resorption is greater in early years than late years of menopause. The decreased bone resorption risk in late postmenopausal women might be due to increased FSH levels. However, further studies are required to explore this finding.

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Section: Discussionmentioning

confidence: 96%

“…Mazzouli et al [5] informed that estrogen dependent bone loss begins in the first year after menopause and is arrested within six years after the onset of menopause. In the present study, from the Figure 1 it is obvious that the bone loss consequent to estrogen deficiency commences in the first year and does not cease.…”

Section: Discussionmentioning

confidence: 99%

Influence of years since menopause on bone mineral metabolism in South Indian women

Suresh

Naidu

2006

Indian J Med Sci

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“…Bone modeling reaches its peak by the early 20s and then declines slowly; early menopause starts by age 45 years with a median age of approximately 51 years. After menopause, the annual bone loss is significant for five years and then stabilizes (Cramer & Xu, 1996;Mazzuoli et al, 2000;U.S. DHHS, 2004).…”

Section: Design and Settingsmentioning

confidence: 99%

Care coordination in bone health screening between individual behaviors and health care services among Korean-American women across three age groups

Lee¹

2017

Asian/Pacific Island Nursing Journal

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Integrated continuous care is important to prevent and treat brittle bone status in the aging process; however, minority groups often have limited access to health services. The purpose of this study was to identify the care coordination among women's perceptions about their bone health, information from health care providers, and the results of Bone Mineral Density (BMD) tests across three age groups. The study was a cross-sectional comparative design. A total of 63 Korean American women completed both the assessment of BMD of the femoral neck and an interview survey. One's own risks of osteoporosis, screening behaviors, and health care providers' advice were analyzed according to three age (pre-, peri-, and post-menopausal) groups, BMD levels, and health insurance coverage. Overall, health insurance coverage and having a primary health care provider of Korean American women were 59.0% and 32.0%, respectively; 61.9% had lower than normal BMD levels, which were significantly increased by advanced age. Individual awareness of risks of osteoporosis and screening behaviors were significantly higher in peri-menopausal than in pre-and post-menopausal groups, but no differences were found in health care providers' information. The awareness and care providers' information by BMD level or health insurance did not differ. The findings show a discrepancy between individual perceptions and behaviors and health care providers' recommendations regard to bone health. Health behaviors should be guided by professional health care providers. The women in the post-menopausal stage need to be educated about the high risk of osteoporosis and its management.

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“…Postmenopausal osteoporosis (PMOP) is a bone disease resulting from low estrogen levels, causing reduced bone mass and bone microstructure degeneration and increased fragility of bones and fractures (1). It is a serious, frequently-occurring disease in older women.…”

Section: Introductionmentioning

confidence: 99%

Screening for specific biomarkers in the serum of postmenopausal osteoporosis patients using proteomic fingerprint techniques

Liu²,

Wang

2012

Biomedical Reports

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Abstract. The aim of this study was to detect serum protein biomarkers and establish a diagnostic model for postmenopausal osteoporosis (PMOP) adopting matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with weak cationic exchange (WCX) magnetic beads, and to study the clinical significance of the model in the early diagnosis of PMOP. Serum samples from 45 patients with PMOP, 30 patients with osteopenia and 40 healthy controls were prepared using WCX magnetic beads, and were then analyzed using a PBSⅡ-C mass spectrometer reader. The protein spectra of the serum samples were normalized using the Ciphergen Proteinchip software. The peak labeling was performed using the Biomarker Wizard software. The specific protein biomarkers were screened using the Biomarker Pattern software to construct a diagnostic model for PMOP. A total of 138 discriminative mass-to-charge (m/z) ratios were found to be associated with PMOP. Of these, the m/z peaks at 3167.4, 4071.1, 7771.7 and 8140.5 were used to construct a diagnostic model in a training set. In a test set, the sensitivity and specificity of the model were 91.11 and 92.86%, respectively. Potential protein biomarkers for PMOP were detected in patient serum using MALDI-TOF MS combined with WCX magnetic beads. This model of multiple biomarkers provided a powerful and reliable diagnostic method for PMOP diagnosis with high sensitivity and specificity. IntroductionPostmenopausal osteoporosis (PMOP) is a bone disease resulting from low estrogen levels, causing reduced bone mass and bone microstructure degeneration and increased fragility of bones and fractures (1). It is a serious, frequently-occurring disease in older women. As estimated by the epidemiological survey in 2009, the incidence of the disease was 19.9 and 24% in women aged >40 and >60 years, respectively. Therefore, PMOP, which has become a serious public health concern, receives much attention (2).With the advances in proteomics research, proteomics techniques show a notably high sensitivity and specificity in screening for biomarkers of various diseases. Currently, an increasing number of studies employs such techniques to investigate the disease-associated whole and differential proteins, in order to explore the composition and dynamic changes of the disease proteins at the whole level to gain a better understanding of the various physiological and pathological processes in individuals, as well as to search for highly effective diagnostic markers of various diseases. Matrix-assisted laser desorption/ionization time-of-light mass spectrometry (MALDI-TOF MS) is a recently emerged proteomics method, with the potential to detect various clinical samples, such as serum, urine, pleural effusion, ascites and a number of secretions (3,4). Therefore, MS technique is a milestone in clinical detection. The present study employed MALDI-TOF MS combined with weak cationic exchange (WCX) magnetic beads to analyze the normal bone mass in postmenopausal women and the serum protein ...

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Annual skeletal balance and metabolic bone marker changes in healthy early postmenopausal women: results of a prospective study

Cited by 34 publications

References 22 publications

Influence of years since menopause on bone mineral metabolism in South Indian women

Influence of years since menopause on bone mineral metabolism in South Indian women

Care coordination in bone health screening between individual behaviors and health care services among Korean-American women across three age groups

Screening for specific biomarkers in the serum of postmenopausal osteoporosis patients using proteomic fingerprint techniques

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