Nowadays mathematical models are widely used to predict climate processes, but less has been done to compare the models. In this study, multiple linear regression (MLR), multi-layer perceptron (MLP) network and adaptive neuro-fuzzy inference system (ANFIS) models were compared in precipitation prediction. The large-scale climate signals were considered as inputs to the applied models. After selecting the most effective climate indices, the effects of large-scale climate signals in seasonal Standardized Precipitation Index (SPI) of Maharlu-Bakhtaran catchment, simultaneously and with the delay, was analysed by cross-correlation function.Consequently, SPI time series was forecasted up to four time intervals by using MLR, MLP and ANFIS. The results showed that the most of the indices were significant with SPI of different lag times. Comparison of the SPI forecast results by MLR, MLP and ANFIS models showed better performance of the MLP network than the other two models (RMSE=0.86, MAE=0.74 for the 1st step ahead of SPI forecasting).